양극성 조증 입원 환자에서 과체중, 비만과 연관 인자 : 예비 연구

정영은,서호준,송후림,왕희령,전태연,박원명,Jung, Young-Eun,Seo, Ho-Jun,Song, Hoo-Rim,Wang, Hee-Ryung,Jun, Tae-Youn,Bahk, Won-Myong 대한불안의학회 2010 대한불안의학회지 Vol.6 No.2

Objective : Being overweight or obesity impairs quality of life and often causes treatment noncompliance in patients with bipolar disorder. This preliminary study evaluated the prevalence of overweight and obesity in inpatients with bipolar mania. Methods : Inpatients with bipolar mania, who were treated with adequate medications at least 4 weeks were included in a retrospective study. The body weight of each patient was measured and the body mass index (BMI) was calculated. Results : Of the 80 patients, 16.4% (N=13) were overweight, and 35.0% (N=28) were obese at discharge. Female patients had higher prevalence rates of overweight and obesity. Being overweight or obesity was associated with the number of previous episodes of depression and combination treatment with atypical antipsychotics and mood stabilizers. Conclusions : Being overweight or obesity is highly prevalent in patients with bipolar mania. Clinicians should pay more attention to weight gain and obesity when prescribing combination therapies. More research is required to identify the impact of specific risk factors for overweight and obesity in patients with bipolar mania.

Ortega의 기술론

정영도(鄭榮道) 대한철학회 1977 哲學硏究 Vol.24 No.-

한글 비단어 탐지에 있어서 글에 대한 친숙도와 단어변형종류의 영향

정영은 충북대학교 인간심리연구소 2018 인간심리연구 Vol.2 No.1

본문 참고

Association between FAT Gene and Schizophrenia in the Korean Population

정영은,전태연 대한정신약물학회 2013 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.11 No.2

Objective: The aim of this study was to investigate the genetic association of the FAT gene with schizophrenia in the Korean population, as well as analyzing the association of FAT gene with clinical variables. Methods: Four variants within the FAT gene were investigated in 189 patients with schizophrenia and 119 healthy controls (rs2306987 A/C, rs2306990 T/C, rs2637777 G/T, and rs2304865 G/C). Results: Significant association at the rs273777 with schizophrenia was observed; however, rs2306987, rs2306990, and rs2304865 were not associated with schizophrenia. Haplotype analyses revealed that the haplotype A/T/T/G was associated with a significantly protective effect. Sliding window analysis (rs2637777 G/T and rs2304865 G/C) revealed the more common T/G haplotype, included in the A/T/T/G protective combination, showed a small protective effect, in particular the effect was due to the rs273777 T variant (minor allele). Conclusion: The present finding suggests that FAT polymorphism may play a putative role in the susceptibility to schizophrenia in the Korean population. Further studies using a larger number of subjects should be performed to determine whether the FAT gene polymorphism may be truly involved in the development of schizophrenia.

범불안장애의 약물치료와 Pregabalin

정영은,채정호 대한정신약물학회 2008 대한정신약물학회지 Vol.19 No.3

Multiple randomized, double-blind, placebo-controlled trials have explored the efficacy of pregabalin for the treatment of generalized anxiety disorder(GAD) and this novel drug was recently approved in Europe. Short-term efficacy of pregabalin as a treatment modality for GAD is well supported by the positive results of several placebo-controlled studies, and most studies confirmed that pregabalin is superior to placebo and comparable with lorazepam, alprazolam and venlafaxine for the treatment of patients with GAD. Especially, pregabalin has a rapid speed of onset combined with equal efficacy in treating both psychic and somatic symptoms of GAD. Additionally, pregabalin has demonstrated potential for the prevention of relapses of GAD. Efficacy in the elderly patients was also shown in a separate placebo-controlled study. Pregabalin has a favorable safety and tolerability profiles relative to benzodiazepines and has minimal potential for drug-drug interactions, abuse and dependence. In the future, research should target further elucidating the efficacy of pregabalin for GAD in relapse prevention, long-term treatment and special populations. Additional studies are needed to guide clinicians in practical issues of how best to use pregabalin as a newer option for the pharmacotherapy of GAD.

양극성장애의 심리사회적 치료

정영은,김문두 대한우울조울병학회 2016 우울조울병 Vol.14 No.1

Treatment of bipolar disorder conventionally focuses on acute stabilization, in which the goal is to bring a patient with mania or depression to a symptomatic recovery with euthymic mood. Substantial progress has been made in the development and assessment of adjunctive psychosocial interventions. Long-term maintenance and relapse prevention can be enhanced by the combination of psychosocial treatments with medications. Early detection combined with helpful self-management and targeted psychosocial and pharmacological treatment promises substantial benefits. The next generation of psychosocial interventions for bipolar disorder will need to systematically assess mediators in the pathways from treatments to changes in illness course. To be economically sustainable, psychosocial intervention protocols need to be made briefer and more efficient for improved sustainability in widespread applications

가미온청음으로 호전된 쇼그렌 증후군 환자 치험 1례

정영은,박정아,김종대,Jeong, Yeong-eun,Park, Chung-a,Kim, Jong-dea 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine, especially Gami-onchung-eum, for treatment of a patient with Sjogren's syndrome. Methods: The patient, diagnosed with Sjogren's syndrome, was suffering from systemic symptoms accompanied by dry mouth, dry eye, and fatigue. We treated her with Korean medicine involving a herbal decoction, acupuncture, moxibustion, and cupping. We used the European League Against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reported Index for assessment. Results: Based on the European League Against Rheumatism $Sj{\ddot{o}}gren^{\prime}s$ Syndrome Patient Reported Index, after 28 days of treatment, dry mouth decreased to a score of 5, dry eye decreased to 2, and fatigue decreased to 3. Conclusions: Korean medicine, including Gami-onchung-eum, may be an effective treatment for Sjogren's syndrome.

에도시대 서민의 다비(旅)에 관한 연구

정영인(鄭英仁)(Jeong, Young-In) 일본어문학회 2011 일본어문학 Vol.54 No.-

江戸時代は色々な階層の人々が全国の街道を往来しながら旅をする時期であったが、初期には社会的なインフラが整備されない状況のために、庶民たちの私的な旅がは自由に行なわれなかった。中期に入って平和が定着され、農民や町人たちの経済力と生活水準の向上に伴って多様な庶民の文化が発達したので、これを基にして旅は次第に大衆化していった。そうではあるが封建制度下での江戸時代は原則的に庶民たちの旅が禁止されていて、特に農民と女性は厳しい統制が行なわれていた。しかし宗敎的な目的の参拜や温泉での湯治は例外に当たったので、庶民たちはこれを口実に旅をする場合が多かった。そして江戸後期になると、参拝を立前にして本音は物見遊覧と日常からの解放感を楽しむ庶民たちの旅が爆発的に増加していった。 本論文は、江戸時代の色々な旅の様子の中でも特に信仰に関する庶民たちの集団的な旅を中心にして、その歴史的な意味と社会に及ぼした影響について考えてみることを目的とする。今日我々が一般的に知っている「観光」または「旅行」としての旅が許されない時代的な状況の中で、お伊勢参りのような大規模の集団的な旅が、権力と制度から抑圧された庶民たちの自我を取り戻すための意識の発露であったということを考察しようとする。

Effects of Osteotomy Angle on Tibial Angulation and Torsion During CORA-Based Leveling Osteotomy in Toy Breed Dogs: A Computer Modeling-Based Study

정영은,정재민,조청운,정성목,이해범 한국임상수의학회 2020 한국임상수의학회지 Vol.37 No.4

The objective of this study was to determine the effect of osteotomy angle and tibial proximal segment rotation angle on angular and torsional tibial deformities and to assess the trends of these deformities during the rotation of the tibial proximal segment in a center of rotation of angulation (CORA)-based leveling osteotomy (CBLO) by performing computer modeling of the tibia. Four tibias of toy breed dogs with no history of lameness were used in this study. Osteotomies were performed in the proximal tibias at angles of 0o, 10o, 20o, 10o, and 20o, perpendicular to either the proximodistal or craniocaudal tibial axes. The mechanical medial proximal tibial angle (mMPTA) and transcondylar (TC) and distal cranial tibial (CnT) axes were used to measure angular and torsional deformities, respectively. All tibias showed an increase in angular and rotational deformities with an increase in the tibial plateau rotation angle. The tibia with osteotomies performed in the proximodistal and craniocaudal directions showed the highest magnitude of torsional and angular deformities, respectively. The results of this study revealed a tendency of occurrence of angular and torsional deformities with osteotomy performed along the proximodistal and craniocaudal directions in the CBLO.

소아청소년 주요 우울장애에서 Fluoxetine 치료 반응과관련된 인자;자연사 연구

정영은,문현진,서호준,박원명,전태연,채정호 대한정신약물학회 2008 대한정신약물학회지 Vol.19 No.2

Objectives: Weevaluated the overall efficacy of fluoxetine and explored factors associated with the response to fluoxetine treatment in child and adolescent outpatients with major depression. Methods: Child and adolescent outpatients with major depressive disorder who had been treated with fluoxetine for at least eight weeks were selected for a retrospective study. The medical records of the subjects (N = 82) were reviewed to determine the details of clinical variables and the efficacy and pharmacological variables of fluoxetine. At eight weeks, Clinical Global Impression (CGI) scores were used to divide the subjects into two groups, i.e., clinical responders and non-responders, and the two groups were compared. Results:Of the 82 patients, 64% (N = 53) responded to fluoxetine treatment. Responders tended to be younger during the treatment period and tended to have had a shorter duration of depressive episodes prior to starting treatment, a lower family loading for depressive illness, and less difficulty in school than non-responders. Other variables did not differ significantly between responders and non-responders. Conclusions: Fluoxetine is effective for the treatment of depressed children and adolescents. Younger age, shorter duration of depressive episodes prior to starting treatment, lower family loading for depressive illness, and less difficulty in school were good predictors of the response to fluoxetine treatment. 본 연구는 후향적 연구 방법을 통해 소아청소년 우울장애에서 fluoxetine 치료에 대한 효능을 조사하고, 그 결과를 통해 fluoxetine의 치료반응과 관련한 인자를 분석하고자 하였다. 주요 우울장애로 진단되어 fluoxetine을 최소 8주 이상 투여 받았던 소아 청소년 외래 환아 82명을 대상으로 의무 기록 검토를 통해 임상적 변인과 fluoxetine 치료 효능을 조사하였다. 대상군을 fluoxetine 투여 후 8주 시점에서의 CGI를 기준으로 반응군과 그렇지 않은 군으로 나누고, 두 군 간의 차이를 비교하였다. 총 대상군의 64.6%(N=53)에서 fluoxetine 치료에 효과가 있는 것으로 조사되었다. 반응군은 그렇지 않은 군에 비해 어린 연령이 많고, 치료 전 우울삽화의 기간이 짧았으며, 기분장애의 가족력과 학교생활의 어려움이 더 적었다. 그 외 다른 변인에서는 두 군 간의 통계적으로 유의한 차이는 없었다. 본 연구 결과 fluoxetine은 소아청소년 우울장애에 효과가 있으며, 어린 연령, 치료 전 우울삽화 기간이 짧고 기분장애의 가족력 및 학교 적응 문제가 없는 경우에 치료 반응이 좋은 것으로 조사되었다.