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최신 연구 소개 : 혈청에 존재하는 Galectin-3 Ligand는 Haptoglobin 관련 당단백질로 대장암 환자에서 증가한다
정성애 ( Sung Ae Jung ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.4
Galectin-3는 정상이나 종양조직에 존재하는 galactose 결합단백질로 세포의 결합이나 성장을 조절하는 데 관여한다. 대장암조직에서 galectin-3는 종양의 병기, 예후, 전이와 관련이 있으며, 혈청 galectin-3도 정상인에 비해 소화기계 종양환자에서 증가한다. 대장암세포주에 존재하는 ligand 중 Mac-2 결합 당단백질, CEA, lamp-1, lamp-2 당단백질이 있으며, 대장암에 존재하는 mu-cin이 galectin-3 l
종설 : 항응고치료를 받는 환자에서 소화기 영역의 내시경 진단과 치료
정성애 ( Sung Ae Jung ) 대한내과학회 2007 대한내과학회지 Vol.72 No.4
Recently, the treatment of anticoagulant and antiplatelet agents for various cardiovacular and neurologic areas has become popular. Optimal endoscopic approach during the management of the anticoagulant requires consideration for relative risks of thromboembolism and bleeding, but the prospective data are limited. For procedures considered to have a low risk of bleeding such as diagnostic endoscopy or colonoscopy with simple biopsy, it is not necessary to discontinue anticoagulation therapy. For procedure with higher risk of bleeding such as endoscopic polypectomy or mucosal dissection, an individual modification of strategy is required. It should be recognized that the risk of thromboembolic event varies according to the underlying condition when adjustment of anticoagulation is required during endoscopic procedure. (Korean J Med 72:333-339, 2007)
1990 년대 한국 성인에서 역류성 식도염의 유병률 변화
정성애(Sung Ae Jung),정훈용(Hwoon Yong Jung),김기락(Ki Rhack Kim),민영일(Young Il Min) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Backgroud/Aims: The prevalence of reflux esophagitis has been considered to be low in Korea, but recent studies suggested that it has been increasing. The prevalence also is generally thought to be less in Korea compared to that in western countries. Methods: Data was collected from the leading medical journals published in Korea dealing with the prevalence of reflux esophagitis for last 10 years between 1990 and 1999 and annual reports of Health Promotion Center in Asan Medical Center of 1997 to 1999. Results: The prevalence was occupied 1.3% in the early period of 1990's, 5.3% in the middle and 7.2% in the late period in symptomatic group and 2.7%, 3.2% and 5.8% in asymptomatic group. The prevalence was reported 5.4% in 1997, 5.3% in 1998 and 7.0% in 1999 in asymptomatic group of annual report of Health Promotion Center in Asan Medical Center. Associated conditions in reflux esophagitis were hiatal hernia, alcohol consumption, smoking and obesity suggesting as risk factors. Conclusions: The prevalence of reflux esophagitis in Korea has increased in last 10 years of 1990' s but is still lower than that in the western countries. Continuous increase in the prevalence of reflux esophagitis in Korea is predictable and it leads to a greater concern for accurate diagnosis and rapid treatment of symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:161-167 )
정성애 ( Sung Ae Jung ) 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.2
요약: 위장관에 대한 oxytocin의 효과는 뚜렷하지 않다. 이 연구는 oxytocin을 주입하였을 때 여성의 대장 운동성 및 감수성을 알아보기 위한 것이다. 14명의 건강한 여성을 대상으로 각각 2주 간격으로 2회 실험하였다. 6개의 채널을 가지고 barostat 풍선에서부터 근위부로 2㎝ 간격의 3개의 측정점이 있고, 풍선에서부터 말단부로 3개의 측정점을 가진 perfusion catheter를 대장의 비장 만곡부까지 삽입하였다. 위-대장 반사의
대장의 점막하 침윤암의 심달도와 림프절 전이에 따른 기질단백분해효소와 억제인자의 발현 및 신생혈관 형성
정성애 ( Sung Ae Jung ),양석균 ( Suk Kyun Yang ),김정선 ( Jeong Sun Kim ),심기남 ( Ki Nam Shim ),임석아 ( Seock Ah Im ),명승재 ( Seung Jae Myung ),정훈용 ( Hwoon Yong Jung ),유창식 ( Chang Sik Yu ),김진천 ( Jin Cheon Kim ),홍원선 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Background/Aims: Lymph node (LN) metastasis occurs in approximately 10% of patients with submucosally invasive colorectal carcinoma. This study was performed to determine the role of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinase
박재정 ( Jae Jung Park ),정성애 ( Sung Ae Jung ),노영욱 ( Young Wook Noh ),김고흔 ( Go Heun Kim ),허현미 ( Hyun Mi Heo ),배서은 ( Suh Eun Bae ),최윤정 ( Yun Jung Choi ),김소이 ( So I Kim ),이명원 ( Myung Won Lee ),강민정 ( Min Jun 대한장연구학회 2009 Intestinal Research Vol.7 No.1
Background/Aims: Primary epiploic appendagitis (PEA) is a rare cause of focal abdominal pain in otherwise healthy patients. Patients with acute abdominal pain are often misdiagnosed clinically as acute appendicitis or diverticulitis. The purpose of this study was to describe the clinical presentation and characteristic computed tomography (CT) findings of PEA. Methods: We reviewed the clinical records and CT images of 23 consecutive patients in Korea who presented with acute abdominal pain between January 2005 and February 2009 and had radiologic signs of PEA. Results: Twenty-three patients (7 females and 16 males; average age, 42±14 years) were diagnosed with symptomatic PEA. Abdominal pain localized to the left (8 patients [44.5%]) and right (10 patients [55.5%]) lower quadrants as the leading symptom. CT findings specific for PEA were present in all patients except one. The symptoms resolved within 1 week (mean, 3.5 days) with or without antibiotic treatment. Conclusions: In patients with localized, sharp, acute abdominal pain not associated with other symptoms, such as nausea, vomiting, fever or atypical laboratory values, the diagnosis of PEA should be considered and the diagnosis confirmed by CT scan. (Intest Res 2009;7:47-51)
강민정 ( Min Jung Kang ),정성애 ( Sung Ae Jung ),정지민 ( Ji Min Jung ),김성은 ( Seong Eun Kim ),심기남 ( Ki Nam Shim ),정혜경 ( Hye Kyung Jung ),구혜수 ( Hea Soo Koo ),유권 ( Kwon Yoo ),문일환 ( Il Hwan Moon ),정규원 ( Kyu Won C 대한소화기기능성질환·운동학회 2008 Journal of Neurogastroenterology and Motility (JNM Vol.14 No.1
Hypoganglionosis is a rare form of intestinal neuronal malformation, which is characterized by scarce ganglia and a reduced number of parasympathetic nerves in the intestinal wall. Enteric nervous system can be damaged during postnatal period by ischemic, inflammatory, autoimmunologic process or neurotoxic agent. Acquired hypoganglionosis is usually late onset and characterized as degeneration of ganglion cells and gliosis histologically. We report a case of adult type ypoganglionosis, which is assumed to be an acquired type with the review of literature. The patient with a history of chronic constipation and ileus presented with intestinal obstruction and went on surgical management successfully.