2008년 중앙일보 신인문학상 - 정상혁

정상혁 고요아침 2008 시조시학 Vol.- No.-

Telmisartan과 Amlodipine의 병용투여에 의한 고혈압 및 심혈관 보호 효과

정상혁,명창선 충남대학교 약학대학 의약품개발연구소 2018 藥學論文集 Vol.33 No.-

Hypertension is a chronic disease whose blood pressure is above normal range. Hypertension is known to cause cardiovascular disease and diabetes. In this study, we aimed to confirm the antihypertensive and cardioprotective effects of by administering alone or in combination of telmisartan (i.p. 7.66 mg/kg) and amlodipine (i.p. 0.96 mg/kg) on spontaneously hypertensive rats (SHRs). As a result, both systolic blood pressure (SBP) and mean arterial pressure (MAP) were decreased with monotherapy of each drug and combined treatment. However, no significance was examined in low and high dose combination as compared with monotherapy of each drug. The infarct size of the left ventricle tended to decrease, and the expression level of eNOS increased when the two drugs were administered concomitantly, but not significantly. Cuff induced neointimal hyperplasia in C57BL/6 mice was significantly reduced by both monotherapy of telmisartan and combined treatment with almodipine. However, the DNA synthesis in neointima and media of vascular smooth muscle was significantly decreased with all treatment protocols. In consistent with in vivo results, [3H] thymidine incoporation in vascular smooth muscle cells (VSMCs) was significantly reduced in all treat ment protocols. Finally, the combined treatment of telmisartan with amlodipine showed a significant ability to lower blood glucose level in streptozotoxin and nicotinamide treated diabetic rats. Taken together, these re suits suggest that the combined administration of telmisartan and amlodipine can be a good strategy for the management of vascular injury and diabetes.

지역사회 진단사업과 발전방향

정상혁 關東大學校 醫科大學 醫科學硏究所 1997 關東醫大學術誌 Vol.1 No.1

The community medicine has been developed from the latter half of the 1960's. The most important parts of community medicine are community medicine are community diagnosis. This study was designed for the porpose of review and recommendation of the health policies of community diagnosis. The major results of this study are as follows. 1) Reset the goals and objectives of community health center. 2) Community diagnosis is excuted by present community health center manpower. 3) National Government must generate the data of community level. 4) Communith diagnosis carry out according to specific goals and objectibes. 5) Communith diagnosis needs standardization. 6) Computerization of process is essential part in communith diagnosis. 7) Community diagnosis must execute periodically and then modify the goals and obfectives.

6‧25전쟁 초기 북한군 도하작전의 실패요인 연구 - 한강 도하 사례를 중심으로 -

정상혁 국방부군사편찬연구소 2019 군사 Vol.- No.110

The purpose of this study is analysing failure factors of the Han-River crossing operations conducted by North Korean troops in the early stage of Korean war. Commonly, there are two factors of the failure based on the strategic and operational level. Firstly, they didn't chase Korean Army in Seoul, so they couldn't secure bridges on the Han-River. Secondly, they had not enough river-crossing equipments suitable for Korean terrain. But it is difficult to explain all aspects of unsuccessful operation. So it was necessary to assess tactical level of North Korean troops during conduct of operations. In the initial phase, they weren't prepared well for the reconnaissance, infiltration, deception and fire support of the river-crossing operation, especially in Han-River. After the Han-River battle, the North Korean troops accomplished some improvement in the tactical capability such as Kum-River crossing operation. But, it was too late for achieving objective of the Korean War. Consequently, in order to understand Han-River crossing operation, we have to analyze strategic, operational and tactical level of conduct of river crossing operation together. 북한군은 국군의 한강선 방어를 허용했기 때문에 작전목표였던 국군의 주력을 섬멸하는데 실패했다. 전쟁 전반을 통틀어 북한의 가장 결정적인 실수 가운데 하나는 신속히 한강을 도하하는데 실패한 것이다. 그러나 유사한 상황이었음에도 북한군은 금강 도하작전은 매우 성공적으로 수행했다. 교량이 파괴되고 도하장비도 부족했던 동일한 상황에서 북한군의 금강 도하는 성공적으로 완수된 반면한강 도하에 실패했던 것을 어떻게 설명해야 할까? 기존 연구에서 주목하는 한강 교량 점령 실패나 도하장비의 부족은 군사전략 및 작전술 차원의 실패요인이었으며 이것으로 인해 전쟁목표 달성에 실패하고 진격속도가 저하되었다. 실질적으로 개별적인 도하작전의 성패는 전술적 능력에 의해 결정되었다. 전쟁 이전 북한군은 소련군의 교범을 번역하여 우수한 교리를 보유했지만 실제 이를 체득할 시간이 부족했다. 또한 도하에 필요한 주요장비는 부족했을 뿐만 아니라 늦게 도착했기 때문에 이를 운용해 볼 시간이 부족했고 도하훈련 역시도 실전을 고려하지 않고 행정적으로 수행되었다. 결국 북한군은 전쟁 초기의 도하작전 준비가 부족했다. 한강 도하에서 북한군은 승리를 위한 결정적인 기회를 상실했다. 김포 방면의 6사단과 서울 방면의 3사단, 4사단, 105전차사단은 각각 6일, 8일 지연됨으로써 전쟁목표를 달성하는데 실패했다. 소련군의 도하작전 교리에서 강조된 정찰, 침투, 기만, 화력지원, 제병협동 등의 전술적 원칙들은 한강에서 전혀 실현되지 않았다. 한강 도하에서의 실패를 교훈으로 삼아 북한군은 전술적인 과오를 개선했지만 이미 결정적인 승리의 기회를 상실한 뒤였다.

논문 : 지역사회 진단사업과 발전방향

정상혁 관동대학교 1997 關東醫大學術誌 Vol.1 No.1

이동 단말기를 위한 XML DBMS 구현

정상혁,주경수 순천향대학교 부설 산업기술연구소 2003 순천향 산업기술연구소논문집 Vol.9 No.1

Nowadays, XML is used for exchanging information and ERP(Enterprise Resource Planning) systems between corporations, and many database products for XML have been developed in the business market. As the use of XML is spreaded to mobile environment, the use of XML in mobile environment is increased such as on-line business, and storing of XML in mobile DB is required to manage efficienty. In this paper, we developed XML DBMS for mobile device that can store XML document XML DBMS is implemented by combining XML adapter with the existent XML DBMS to store XML document directly. By XML DBMS for mobile device, we can manipulate XML data easily, and maximize the practical use of mobile device.

공공보건의료 서비스 확충과 민간병원 발전과의 조화

정상혁,Jeong, Sang-Hyeok 대한병원협회 2005 대한병원협회지 Vol.34 No.6

A Longitudinal Study of the Relationship Between Health Behavior Risk Factors and Dependence in Activities of Daily Living

정상혁,박경옥,Jung, Sang-Hyuk,Ostbye, Truls,Park, Kyoung-Ok The Korean Society for Preventive Medicine 2006 예방의학회지 Vol.39 No.3

Objectives: The purpose of this study was to shed further light on the effect of modifiable health behavior risk factors on dependence in activities of daily living, defined in a multidimensional fashion. Methods: The study participants were 10,278 middle aged Americans in a longitudinal health study, the Health and Retirement Survey (HRS). A multi-stage probability sampling design incorporating the effect of population sizes (Metropolitan and non-metropolitan), ethnicity (the non- Hispanic White, the Hispanic, and the Black), and age (age 51-61) was utilized. Basic Activities of Daily Living (ADL) were measured using five activities necessary for survival (impairment in dressing, eating, bathing, sleeping, and moving across indoor spaces). Explanatory variables were four health behavior risk factors included smoking, exercise, Body Mass Index (BMI), and alcohol consumption. Results: Most participants at baseline were ADL independent (1992). 97.8% of participants were independent in all ADL's at baseline and 78.2% were married. Approximately 27.5% were current smokers at baseline, and the subjects reported moderate or heavy exercise were 74.8%. All demographic characteristics and behavioral risk factors were significantly associated with the ADL status at Wave 4 except alcohol consumption. Risk behaviors such as current smoking, sedentary life style and high BMI at Wave 1 were associated with ADL status deterioration; however, moderate alcohol consumption tended to be more related to better ADL status than abstaining at Wave 4. ADL status at Wave 1 was the strongest factor and the next was exercise and smoking affecting ADL status at Wave 4. People who were in ADL dependent at Wave 1 were 15.17 times more likely to be ADL dependent at Wave 4 than people who were in ADL independent at Wave 1. Concerning smoking cigarettes, people who kept only light exercise or sedentary life style at Wave 1 were 1.70 times more likely to be died at Wave 4 than the people who did not smoke at Wave 1. Conclusions: All demographics and health behaviors at wave 1 had consistently similar OR trends for ADL status to each other except alcohol consumption. Smoking and exercise in health behaviors, and age and gender in demographics at Wave 1 were significant factors associated with ADL group separation at Wave 4.

병원 특성에 따른 건당 진료비 분석 - 급성충수염과 정상분만을 대상으로 -

정상혁,유승흠,김한중,Jung, Sang-Hyuk,Yu, Seung-Hum,Kim, Han-Joong 대한예방의학회 1990 예방의학회지 Vol.23 No.2

To identify the factors influencing the charges per case of acute appendicitis and normal spontaneous vaginal delivery (NSVD), the personal data-base files and hospital-characteristics-reporting data files of Korea Medical Insurance Corporation were analyzed. One hundred and twenty-nine institutions were selected. The results of this study were as follows 1. The differences of charges per case with respect to hospital ownership, location, and equipment levels were statistically significant. 2. The results of multiple regression analysis revealed that bed capacity was the most significant variable in both diseases. 3. Ownership was significant variable in acute appendicitis. In NSVD, ownership and hospital equipment level were statistically significant. In conclusion, bed capacity was statistically the most significant variable in the analysis of charages per case. And we thought that the results of this study would influence the policy of the hospital bed supply.

Nanoparticle Multilayer Films based on Layer-by-Layer Assembly through Photo-Crosslinking Reaction

정상혁,조진한 한국고분자학회 2013 한국고분자학회 학술대회 연구논문 초록집 Vol.2013 No.10