저탄소 축산식품 인증제도 도입을 위한 활용기술

정다운,김영순,황인호,Jeong, Dawoon,Kim, Young soon,Hwang, Inho 한국축산식품학회 2022 축산식품과학과 산업 Vol.11 No.2

KCNQ1 S140G 돌연변이 발현과 심실세동과의 상관관계 분석을 위한 컴퓨터 시뮬레이션 연구

정다운,임기무,Jeong, Daun,Lim, Ki Moo 대한의용생체공학회 2017 의공학회지 Vol.38 No.3

Background and aims: The KCNQ1 S140G mutation involved in $I_{ks}$ channel is a typical gene mutation affecting atrial fibrillation. However, despite the possibility that the S140G gene mutation may affect not only atrial but also ventricular action potential shape and ventricular responses, there is a lack of research on the relationship between this mutation and ventricular fibrillation. Therefore, in this study, we analyzed the correlation and the influence of the KCNQ1 S140G mutant gene on ventricular fibrillation through computer simulation studies. Method: This study simulated a 3-dimensional ventricular model of the wild type(WT) and the S140G mutant conditions. It was performed by dividing into normal sinus rhythm simulation and reentrant wave propagation simulation. For the sinus rhythm, a ventricular model with Purkinje fiber was used. For the reentrant propagation simulation, a ventricular model was used to confirm the occurrence of spiral wave using S1-S2 protocol. Results: The result showed that 41% shortening of action potential duration(APD) was observed due to augmented $I_{ks}$ current in S140G mutation group. The shortened APD contributed to reduce wavelength 39% in sinus rhythm simulation. The shortened wavelength in cardiac tissue allowed re-entrant circuits to form and increased the probability of sustaining ventricular fibrillation, while ventricular electrical propagation with normal wavelength(20.8 cm in wild type) are unlikely to initiate re-entry. Conclusion: In conclusion, KCNQ1 S140G mutation can reduce the threshold of the re-entrant wave substrate in ventricular cells, increasing the spatial vulnerability of tissue and the sensitivity of the fibrillation. That is, S140G mutation can induce ventricular fibrillation easily. It means that S140G mutant can increase the risk of arrhythmias such as cardiac arrest due to heart failure.

텍스트 마이닝에 기반한 U-City 서비스 이슈 및 동향분석 - 네트워크분석 및 정보량계측기법을 활용하여 -

정다운,유지송,이미숙,신동빈,Jeong, Dawoon,Yoo, Jisong,Yi, Mi-Sook,Shin, Dong Bin 대한공간정보학회 2015 한국공간정보학회지 Vol.23 No.3

최근 정부는 U-City 활성화를 위한 발전전략을 통해 시민들이 체감하는 서비스를 발굴 및 제공하는 것을 목표로 하고 있다. 이에 본 연구는 신문기사 중 U-City 서비스관련 기사를 대상으로 시사분석을 통해 서비스 이슈와 동향을 분석하여 시민체감형 서비스 추진방향을 모색하는데 목적이 있다. 분석을 위해 2009년부터 2014년까지 수집된 723개 신문기사는 전처리과정을 거쳐 키워드 빈도분석을 실시했으며, 빈도분석 결과를 바탕으로 네트워크 분석과 정보계측기법을 활용했다. 네트워크 분석결과 연결 중심성, 매개 중심성, 근접 중심성이 높은 키워드는 정보, IT, 환경, 기술, 센터 순으로 나타났다. 5개의 키워드는 지난 6년 동안 U-City를 추진하는데 있어 중요한 요소였다는 것을 알 수 있다. 정보계측기법결과 기존에 추진된 U-City는 인프라 구축에 중심을 뒀으며, 공공중심의 서비스를 제공했다는 동향을 파악할 수 있었다. 2009년은 관광, 2010년은 방범 방재, 2011년은 시설물 관리, 2012년은 행정, 2013년 2014년은 시설물 관리 분야를 중심적으로 서비스를 개발했다. 이에 기존에 구축된 인프라를 기반으로 시민체감도가 높은 서비스분야의 발굴 및 제공이 필요하다는 시사점을 도출하였다. 본 연구는 추후 U-City를 추진하는 지자체의 계획수립에 참고적인 역할을 할 수 있을 것으로 기대된다. Recently, the government aims to discover and provide services to citizens on the development strategy for activating the U-City. So, this study aims to offer a service discovery direction by analyzing the service issues and trends. The target is newspaper article about U-City Service from 2009 to 2014. Prepared 723 newspaper article for analysis. Next step is frequency analysis of keyword and used that result for Network analysis and measure of information. Network analysis can show result through "Degree Centrality", "Betweenness Centrality" and "Closeness Centrality". As a result, "Information", "IT", "Environment", "Technology", "Center" is higher than another. These 5 keywords are important factors for driving the U-City the past six years. Information measurement results, Already U-City were put an emphasis on building the infrastructure and able to identify a trend that provided the center of the public service. Those Service field are "Tour(2009)", "Crime prevention and Disaster Prevention(2010)", "Facility Management(2011)", "administration(2012)" and "Facility Management(2013, 2014)". Result of this study found implications what on citizen participation. So, services field on the existing infrastructure should be discovered and provided. Finally, this study can expected to be a reference in the local government planning for U-City.

피부전기활동을 이용한 실시간 깊은 수면 검출 알고리즘의 개발

정다운,최상호,주광민,이유진,정도언,박광석,Jung, Da Woon,Choi, Sang Ho,Joo, Kwang Min,Lee, Yu Jin,Jeong, Do-Un,Park, Kwang Suk 대한의용생체공학회 2015 의공학회지 Vol.36 No.5

Although many studies have analyzed the relationship between electrodermal activity (EDA) and sleep stages, a practical method for detecting sleep stage using EDA has not been suggested. The aim of this study was to develop an algorithm for real-time automatic detection of deep sleep using the EDA signal. Simultaneously with overnight polysomnography (PSG), continuous measurement of skin conductance on the fingers was performed for ten subjects. The morphometric characteristics in the fluctuations of EDA signal were employed to establish the quantitative criteria for determining deep sleep. The 30-sec epoch-by-epoch comparison between the deep sleep detected by our method and that reported from PSG exhibited an average sensitivity of 74.6%, an average specificity of 98.0%, and an average accuracy of 96.1%. This study may address the growing need for a reliable and simple measure for identifying sleep stage without a PSG.

시판 레토르트식품의 지방함량 조사 - 조지방, 포화지방, 트랜스지방산 중심으로 -

정다운,임준,김천회,김영경,박윤진,엄애선,Jeong, Da-Un,Im, June,Kim, Cheon-Hoe,Kim, Young-Kyoung,Park, Yoon-Jin,Om, Ae-Son 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.5

본 연구는 레토르트식품의 조지방, 포화지방, 트랜스지방의 영양성분 표시 값과 분석 값을 비교하여 소비자에게 신뢰성 있는 영양정보를 제공하는지를 확인하기 위해 카레류 21건, 짜장류 16건, 짜장 및 카레를 제외한 소스류 17건, 즉석조리식품 16건을 서울 및 경기지역을 중심으로 수거하여 식품공전에 따라 분석하였으며 그 결과는 다음과 같다. 레토르트식품의 지방성분 함량 분포는 조지방 $0.47{\pm}0.42{\sim}17.41{\pm}0.41g/100g$, 포화지방 $0.24{\pm}0.02{\sim}7.60{\pm}0.40g/100g$, 트랜스지방 $0.00{\pm}0.00{\sim}0.46{\pm}0.05g/100g$의 범위를 보였으며, 이는 제품에 표시된 영양성분 함량 대비 각각 최대 회수율 값이 조지방(119.7%), 포화지방(119%), 트랜스지방(90%)로 모두 120%미만의 결과이며 레토르트 70건이 허용 오차 기준을 준수하고 있었다. 이상의 결과를 종합해 보면 레토르트식품에 표시된 조지방, 포화지방, 트랜스지방 함량은 소비자에게 신뢰성 있는 영양정보를 제공하고 있음을 확인하였으며, 현재 한국의 비만 유병률이 31~32%인 시점에서 소비자들이 식품에 표시된 조지방, 포화지방, 트랜스지방 함량을 확인하여 구매한다면 건강에 적합한 식품을 선택할 수 있을 것으로 판단된다. 또한 지속적으로 의무영양표시 식품을 대상으로 제품에 표시된 영양표시의 기준이 준수되고 있는 지에 대한 영양성분 함량 표시 조사 연구가 필요하다고 본다. The aim of this study was to provide nutrition information to consumers by analyzing crude fat, saturated and trans fatty acids in commercial retort foods (n=70). The following sauce products of curries (n=21) and black-bean-sauces (n=16), other sauces (n=17) and instant cooking foods (n=16) were collected. Crude fat contents were quantified with the Rose-Gottlieb method using acid digestion. While saturated and trans fatty acids were examined by gas chromatography with a flame ionization detector (FID). Crude fat, saturated and trans fatty acid content ranges were $0.47{\pm}0.42{\sim}12.80{\pm}0.07g/100g$, $0.24{\pm}0.02{\sim}17.41{\pm}0.41g/100g$, $0.00{\pm}0.00{\sim}0.46{\pm}0.05g/100g$, respectively. Maximum recovery of analysis values was crude fat (119.7%), saturated fat (119%) and trans fatty acid (90%) compared the actual amounts based on the reference value indicated on the nutrition label. The analyzed samples were found to be compliant with nutrition label standard, because the contents of crude fat, saturated fatty acid, trans fatty acid were less than 120% of the reference value indicated on the nutrition label in retort foods. Therefore, the nutrition information on retort foods available to consumers was found to be trustworthy.

다형 심실빈맥의 예측을 위한 dVm/dt_{Max_repol}의 이온채널 전도도에 대한 민감도 분석

정다운,유예담,임기무,Jeong, Da Un,Yoo, Yedam,Marcellinus, Aroli,Lim, Ki Moo 대한의용생체공학회 2022 의공학회지 Vol.43 No.5

Early afterdepolarization (EAD), a significant cause of fatal ventricular arrhythmias including Torsade de Pointes (TdP) in long QT syndromes, is a depolarizing afterpotential at the plateau or repolarization phase in action potential (AP) profile early before completing one pace. AP duration prolongation is related to EAD but is not necessarily accounted for EAD. Several computational studies suggested EAD can form from an abnormality in the late plateau and/or repolarization phase of AP shape. In this sense, we hypothesized the slope during repolarization has the characteristics to predict TdP risk, mainly focusing on the maximum slope during repolarization (dVm/dt_{max_repol}). This study aimed to predict the sensitivity of dVm/dt_{max_repol} to ion channel conductances as a TdP risk metric through a population simulation considering multiple effects of simultaneous reduction in six ion channel conductances of g_NaL, g_Kr, g_Ks, g_to, g_K1, and g_CaL. Additionally, we verified the availability of dVm/dt_{max_repol} for TdP risk prediction through the correlation analysis with qNet, the representative TdP metric. We performed the population simulations based on the methodology of Gemmel et al. using the human ventricular myocyte model of Dutta et al. Among the sixion channel conductances, dVm/dt_{max_repol} and qNet responded most sensitively to the change in g_Kr, followed by g_NaL. Furthermore, dVm/dt_{max_repol} showed a statistically significant high negative correlation with qNet. The dVm/dt_{max_repol} values were significantly different according to three TdP risk levels of high, intermediate, and low by qNet (p<0.001). In conclusion, we suggested dVm/dt_{max_repol} as a new biomarker metric for TdP risk assessment.

치성 점액종 환자의 총의치 수복증례

정다운,김현희,배정윤,Jeong, Da-Woon,Kim, Hyun-Hee,Bae, Jung-Yoon 대한치과보철학회 2018 대한치과보철학회지 Vol.56 No.1

치성점액종은 악골에 드물게 발생하는 양성 치성 종양이다. 본 증례의 60대 무치악 남성은 전상악부에 발생한 연조직 종괴 제거를 주소로 내원하였으며 절제 생검 결과 치성 점액종으로 확진되었다. 외과적 제거 후 잔존한 가동조직의 변형을 최소화 하기 위해 고안된 투명 레진 트레이로 인상을 채득하였다. 악간관계기록 및 납의치 시적시에 중립대 영역을 설정하고 기능적 연마면 형태를 인기하여 총의치의 안정성과 유지력을 증진시킬 수 있었다. 치성 점액종 제거 후 가동조직과 중립대를 고려하여 심미적, 기능적으로 만족스러운 총의치를 제작하였기에 이를 보고하는 바이다. Odontogenic myxoma of the jaws is a rare benign odontogenic tumor. In this case, a 61-year-old male patient had a chief complaint about maxillary anterior gingival mass and excisional biopsy result confirmed odontogenic myxoma. The clear acrylic resin custom tray was designed to minimize displacement of flabby tissue which remained after the surgery. Neutral zone and external impression technique could provide satisfactory result in terms of denture stability and retention during jaw relation record and wax denture try-in procedure. This clinical report describes fabrication of complete dentures for a patient with odontogenic myxoma in regard to flabby tissue and neutral zone.

ZnSe:Eu 양자점의 표면결함이 광학특성에 미치는 영향

정다운,박지영,서한욱,임경묵,성태연,김범성,Jeong, Da-Woon,Park, Ji Young,Seo, Han Wook,Lim, Kyoung-Mook,Seong, Tae-Yeon,Kim, Bum Sung 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.5

Quantum dots (QDs) are capable of controlling the typical emission and absorption wavelengths because of the bandgap widening effect of nanometer-sized particles. These phosphor particles have been used in optical devices, photovoltaic devices, advanced display devices, and several biomedical complexes. In this study, we synthesize ZnSe QDs with controlled surface defects by a heating-up method. The optical properties of the synthesized particles are analyzed using UV-visible and photoluminescence (PL) measurements. Calculations indicate nearly monodisperse particles with a size of about 5.1 nm at $260^{\circ}C$ (full width at half maximum = 27.7 nm). Furthermore, the study results confirm that successful doping is achieved by adding $Eu^{3+}$ preparing the growth phase of the ZnSe:Eu QDs when heating-up method. Further, we investigate the correlation between the surface defects and the luminescent properties of the QDs.

Selective Oxidation of Methyl Substituted 1,3-Dimethyllumazine Derivatives with Nitric acid

정다운,김연희,강영한,백대진,Jeong, Da Un,Kim, Yeon Hui,Gang, Yeong Han,Baek, Dae Jin Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.1

시판 가공식품의 비타민 A, E 함량 조사 연구 - 음료수, 시리얼, 과자, 기타코코아·당류·초콜릿가공품 등을 중심으로 -

정다운,이헌옥,김영경,엄애선,Jeong, Da-un,Lee, Heon-Ok,Kim, Young-Kyoung,Om, Ae-Son 한국식품조리과학회 2016 한국식품조리과학회지 Vol.32 No.6

Purpose: People have long been interested about antioxidant nutrients such as vitamin A and E to stay in healthy states. This present study provides trustworthy nutritional information and evaluates vitamin A and E contents in emphasized food items. Methods: Vitamin A or vitamin E emphasized foods including beverage, cereal, snack, chocolate product, other cocoa products, and sugar products were analyzed. The contents of vitamin A, E in samples were examined by high performance liquid chromatography. Vitamin A and vitamin E contents were compared with the labeled value indicated on the nutrition label. Results: Vitamin A (n=18) value ranged from 90% to 248% and vitamin E (n=20) value ranged between 96-413% of labeled value. Analyzed samples ranged more than 80% of the labeled value, which complied with food labeling rules. Conclusion: Providing accurate information for nutrition label is essential to confirm nutrient contents in foods. It will help to decide the adequate level of nutrient intake. Therefore, the nutrition labeling system should be supervised continuously with regular monitoring analysis.