식도정맥류 출혈의 내시경적 결찰요법의 임상적고찰

정경태,박병수,최호순,고정희,박강서,조병석,이현상,최덕례 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.3

Endoscopic infection sclerotherapy(EIS) has been shown to be the most effective simple method for control of bleeding and eradication of varices. This method has been accepted widely as a standard treatment of bleeding esophageal varices. However, EIS may be associated with undesirable local and systemic complications. Endoscopic variceal ligation(EVL) was first described in 1986 by Stiegmann et al, which consists of mechanical ligation and thrombosis of varices using elastic $quot;0$quot;-ring. EVL has been shown to control active bleeding and to eradicate varices when sessions are repeated. The purpose of this study was to compare with change of esophageal variceal form, with respect to safety, efficacy and complications of EVL in the each sessions. We performed EVL in 43 patients who had recently bled from esophageal varices. Total 679 variceal ligations were performed during 174 separyte EVL sessians. Eighteen(94.7%) of those actively bleeding(19 patients) at initial treatment had bleeding controlled at initial session. During the study period two patients died after 1st and 3rd session, one who died from aggravation of concomitant hepatoma with rebleeding, the other died from early massive rebleeding after 3rd session. Rebleeding, before eradicates varices, occured in 7 patients(16.3%) two patients had bled from varices with aggravation of concomitant hepatoma, other 2 patients had bled from early varices ligation, other 3 patients had bled from re-varices formation in fundus of the stomach. Varices were eradicated or reduced to F₁ in 36 patients(87.8%) of the 41 follow up patients. Each patient received mean 15.8 ligations and 4.1 sessions during the 1st to 6th sessions. Eradication rate of varices(F_0) has increased from the 3rd to the 4th session periods. Improvement rate of varices(F₁) has increased from the 1st to the 3rd session periods. During the 5th or the 6h EVL sessions, eradication and improvement rate of esaphageal varices has been shown to decreased. During or after EVL, there were no major complications, except mild chest discomfort in 6 patients, early bleeding in 2 gatients, mild dysphagia in one patient of 43 patients. According to this study, EVL appears to control active variceal bleeding and eradicate varices with repeat treatments. It is a safe and effective treatment for esophageal varices bleeding. We recommended EVL as an alternative to EIS over the 5th sessions.

저공해성 환경 대응도료의 기술개발 동향에 대하여

정경태 한국공업화학회 1995 한국공업화학회 심포지엄 Vol.0 No.-

A Case of Apical Hypertrophic Cardiomyopathy Combined Acute Myocardial Infarction with Multiple Coronary Thrombosis

정경태,박순창,최유정,이상,이경진,김정희,윤현수 한국심초음파학회 2008 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.16 No.3

We report a case of apical hypertrophic cardiomyopathy combined with acute myocardial infarction and multiple coronary thrombosis. The patient presented with signs and symptoms of acute myocardial infarction, showing ST elevation in the lateral leads and ST depression in anterior chest leads on initial electrocardiogram. The coronary angiogram on admission, multiple thrombosis of distal left anterior descending artery, left circumflex, diagonal and obtuse marginal arteries were found. The present case shows that apical hypertrophic cardiomyopathy can be combined with acute myocardial infarction and multiple coronary thrombosis. We report a case of apical hypertrophic cardiomyopathy combined with acute myocardial infarction and multiple coronary thrombosis. The patient presented with signs and symptoms of acute myocardial infarction, showing ST elevation in the lateral leads and ST depression in anterior chest leads on initial electrocardiogram. The coronary angiogram on admission, multiple thrombosis of distal left anterior descending artery, left circumflex, diagonal and obtuse marginal arteries were found. The present case shows that apical hypertrophic cardiomyopathy can be combined with acute myocardial infarction and multiple coronary thrombosis.

An Analytical Investigation on the Build-up of the Temperature Field due to a Point Heat Source in Shallow Coastal Water with Oscillatory Alongshore-flow

정경태,염기대,강석구,장찬주,이호진,Chong Hak Kim 한국해양과학기술원 2003 Ocean and Polar Research Vol.25 No.1

B3 공정의 유가공 폐수 처리 특성 평가

정경태,정연구 한국수처리학회 2022 한국수처리학회지 Vol.30 No.4

As the milk processing wastewater contains large amount of soluble substances and its quality and quantity changes widely, it is not easy to treat efficiently. In this work, we investigated two biological processes for milk processing wastewater treatment, the oxidation ditch process for S Milk Y plant and the B3 process for S Milk G plant. The comparison was made using the one year operation results of these two full-scale plants focusing on the removal of organic matters and nutrients(N, P). Based on the steady state data of the B3 process, hydraulic retention time (HRT) of 3.2 days and sludge retention time (SRT) of 13.8 days were found to be appropriate for milk processing wastewater. Under these conditions the removal efficiencies of organic matters in terms of BOD, CODMn and SS were 99.7%, 98.4% and 99.5%, respectively. In addition, the removal of T-N and T-P amounted to 91.9% and 96.9%, respectively. Therefore, it was confirmed that organic matter and nutrients in milk processing wastewater can be effectively treated with the B3 process if proper operating conditions are maintained. When compared with the oxidation ditch process, the B3 process showed greater removal efficiencies especially for nitrogen and phosphorus. .

건축디자인에서의 크리스털(Crystal) 원리 적용에 관한 연구

정경태 대한건축학회지회연합회 2019 대한건축학회연합논문집 Vol.21 No.1

Nowadays, architects have sought variety of approaches to discovering a geometrical algorithm in nature and speculating new architectural forms. This study aims to establish the direction of the actual architectural design process based on the theoretical research of architectural design process using the properties of crystal. It is meaningful that the research may lead to in-depth and diverse form finding speculation in the morphological aspect. Furthermore, it is crucial to create unexpected architectural forms. In this study, the geometrical feature and material properties of crystal focusing Pyrite were analysed and applied from the initial stage of design to the final architectural implementation stage. The specific process to develop this is divided into four stages: investigation and analysis of crystal, prototype form, single crystalline space and implementation of crystal architecture. The new form finding is not an architect's creation, but an architectural form that is discovered within the algorithm, the design language inventory, and the materiality reflecting direct and indirect investigation and analysis of the crystal. It is anticipated that this study will prove invaluable reference, help architects and design professionals speculate unpredictable form finding, which is followed by the continued crystal analysis and application to architecture design. 오늘날 건축가들은 자연에서 기하학적 원리를 발견하여 새로운 건축적 형태를 찾아내기 위해 다양한 접근 방법을 모색해 왔다. 본 연구에서는 크리스털의 특성과 이를 적용한 건축디자인 사례들의 이론적 고찰을 바탕으로 실제 건축디자인 프로세스의 방향성을 정립하고자하였다. 이 연구를 통해 심도 있는 다양한 형태적 연구가 이뤄질 수 있고, 더 나아가 결과물로서 예상치 못한 흥미로운 건축적 형태를 창출해 낼 수 있다는데 그 의의가 있다. 이에 본 연구에서는 황철석(Pyrite)을 중심으로 크리스털의 기하학적 특징과 재료적 물성을 분석한 후, 디자인 초기 단계부터 최종 건축적 실현 단계까지 적용하였다. 이를 발전시켜 나가는 구체적인 프로세스를 크리스털에 대한 조사 분석, 프로토타입(prototype) 구축 , 크리스털라인 단일 공간, 크리스털 건축의 실현의 네 단계로 구분하여 제시하였다. 본 연구에서의 새로운 형태는 건축가가 창조해내는 것이 아닌 크리스털에 대한 직간접적인 조사 분석을 통해 구축된 알고리즘과 설정된 디자인 언어, 그리고 물성이 그대로 반영되어 그 건축적 형태가 발견되어지는 것이다. 건축가들, 그리고 디자인 관련 전문가들에게 예측 불가능한 새로운 형태를 찾기 위한 참고자료가 될 것이며, 향후 지속적인 크리스털에 대한 분석과 설계에의 적용에 관한 연구가 이뤄지기를 기대한다.

Salmonella typhimurium lipid A를 처리한 식세포 존재 조건에서 mitogen에 유도되는 이자 세포의 증식억제

정경태,강경숙 한국생명과학회 2007 생명과학회지 Vol.17 No.2

사람의 장티푸스 연구는 생쥐에 감염되는 Salmonella typhimurium를 모델로 연구되고 있으며, 생쥐에 있어서 S. typhimurium의 감염은 이자세포의 증식반응을 감소시키는 것으로 알려져 있다. S. typhimurium lipid A의 처리가 T 세포 mitogen에 의한 이자 세포의 증식에 어떤 영향을 주는 가를 in vitro와 ex vivo 조건에서 알아 보았다. Lipid A 단독 처리는 이자 세포의 증식을 보였으나, lipid A 처리 후 T 세포 mitogen인 concanavalin A (Con A)와 phytohemagglutinin (PHA)에 의한 in vitro와 ex vivo 조건에서의 이차 처리는 오히려 세포증식이 억제되었다. Lipid A를 주사한 생쥐로부터 분리한 이자 세포에서 대식세포를 제거하였을 조건에서는 T 세포 mitogen에 의한 증식 효과가 유지되었으나 대식세포를 제거하지 않았을 경우에는 T 세포 mitogen에 의한 증식 효과가 억제되었다. Lipid A를 주사한 생쥐에서 얻은 대식세포를 포함한 이자세포의 숫자를 증가하면서 Lipid A를 주사하지 않은 생쥐에서 얻은 이자세포와 혼합 배양하였을 때 Lipid A를 주사한 생쥐에서 얻은 대식세포를 포함한 이자세포의 숫자가 높을수록 Con A와 PHA에 의한 증식억제가 높게 측정되었다. 이러한 결과는 Con A와 PHA의 이자세포 증식 기능이 lipid A의 전처리에 의해 활성화된 대식세포의 직접적인 접촉 작용으로 억제된 것으로 생각된다. 본 연구의 결과를 바탕으로 억제에 관여하는 대식세포 표면분자를 밝히는 것이 사람의 장티푸스 연구에 도움이 되리라 생각된다. Infection with virulent or attenuated Salmonella typhimuriumhas known to induce reduction in proliferative responses of spleen cells. We investigated a role of lipid A from S. typhimurium, a B cell mitogen, on proliferation of spleen cells by T cell mitogens such as concanavaline A and phytohemagglutinin under in vitro and ex vivo conditions. Lipid A alone induced proliferation of spleen cells in vitroin a dose-dependent manner. However, subsequent treatment of concanavaline A or phytohemagglutin in after lipid A treatment induced proliferation suppression of murine spleen cells in vitro and ex vivo. Removal of macrophages from spleen cells, which were obtained from a lipid A-injected mouse, restored proliferation by concanavaline A and phytohemagglutinin, indicating that macrophages appeared to play a role in lipid A-induced suppression. Secreted molecules from macrophages did not accounted for the suppression because suppressive effect was not achieved when the supernatant from macrophage-containing spleen cell culture was conditioned to macrophage-depleted spleen cell culture. Co-culture of spleen cells from lipid A-treated and –untreated mice showed proliferation suppression as increasing cell numbers of lipid A-treated mouse. These data suggested that the cell-to-cell contact of macrophage with splenic lymphocyte cells is responsible for immune responses against lipid A, which is applicable to the case of human S. typhi infection.

학술발표(學術發表) 연제(演題) 및 초록(抄錄) 제사부(第四部): 공중위생(公衆衛生),생리(生理),어병(魚病),법령(法令),분야(分野) : 24. 시험동물에서 설파제 투여에 의한 체내잔류량 조사

정경태,조헌호,이강록,김근규 한국가축위생학회 1997 학술대회논문집 Vol.1997 No.-

Eight-dimensional Einsteins connection for the second class I. The recurrence relations in 8-g-UFT

정경태,Soo Kyung Han,황인호 호남수학회 2004 호남수학학술지 Vol.26 No.4

Lower dimensional cases of Einstein’s connection were already investigated by many authors for n = 2; 3; 4; 5; 6; 7. This paper is the first part of the following series of two papers, in which we obtain a surveyable tensorial representation of 8-dimensional Einstein’s connection in terms of the unified field tensor, with main emphasis on the derivation of powerful and useful recurrence relations which hold in 8-dimensional Einstein’s unified field theory(i.e., 8-g-UFT): I. The recurrence relations in 8-g-UFT II. The Einstein’s connection in 8-g-UFT All considerations in these papers are restricted to the second class only, since the case of the first class are done in [1], [2] and the case of the third class, the simplest case, was already studied by many authors.

Isolation of Proteins that Specifically Interact with the ATPase Domain of Mammalian ER Chaperone, BiP

정경태,Tae Ho Lee,Gyong Suk Kan 한국생물공학회 2003 Biotechnology and Bioprocess Engineering Vol.8 No.3

BiP, immunoglobulin binding protein, is an ER homologue of Hsp70. However, unlike other Hsp70 proteins, regulatory protein(s) for BiP has not been identified. Here, we demonstrated the presence of potential regulatory proteins for BiP using a pull-down assay. Since BiP can bind any unfolded protein, only the ATPase domain of BiP was used for the pull-down assay in order to minimize nonspecific binding. The ATPase domain was cloned to produce recombinant protein, which was then conjugated to CNBr-activated agarose. The structural conformation and ATP hydrolysis activity of the recombinant AT-Pase domain were similar to those of the native protein. Eight proteins from metabolically labeled mouse plasmacytoma cells specifically bound to the recombinant ATPase protein. The binding of these proteins was inhibited by excess amounts of free ATPase protein, and was dependent on the presence of ATP. These proteins were eluted by ADP. Of these proteins, Grp170 and BiP where identified, while the others were not identified as known ER proteins, from Western blot analyses. The presence of the ATPase-binding proteins for BiP was first demonstrated in this study, and our data suggest similar regulatory machinery for BiP may exist in the ER, as found in prokaryotes and other cellular compartments.