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전흥원,지상철,단현광 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.2
The ulcerogenic activity of a 3% ketoprofen gel (ID-GEL) after its transdermal application in rats was determined with the Litchfield and Wilcoxon method in reference to the oral administration of ketoprofen in a suspension. The UD_(50) (dose producing ulcers in 50% of the rats tested) of ID-GEL after its transdermal application was approximately 4 times greater than that after the oral administration of the drug, indicating that the ulcerogenic activity of ketoprofen was much lowered with its transdermal application.
美國藥學敎育 : 基礎科學 中心에서 臨床藥學 中心으로의 轉換
전흥원 한국병원약사회 1991 병원약사회지 Vol.8 No.1
미국에서의 약학교육은 지난 20년간 중대한 변화를 겪어왔따. 1970년경 임상약학이라는, 약학실무에 있어서의 새로운 개념은 각 약학대학의 주된 학문적 교육목표로써 확고히 정착되었다. 이런 변화는 임상약학의 발전을 위한 임상교수진의 임명, 연구활동, 학술지 발간 등의 극적인 증가를 불러왔다.최근에 이르러서는 미국 약학대학의 전 교수진의 1/3은 임상교수로 되어 있다.
전흥원,김용수,태순호 한국산업안전학회 2002 한국안전학회지 Vol.17 No.2
At present, the Polyethylene piping, on supporting LNG is widely used because of it's disposition which are anti-corrosion, flexible and so on. However, it has a few kinds of risk which are the possibility of piping leak, the character of easily corroded and so on. For giving solution, this study is intended to experiment the intension of the PE pipe after melted and when it is melting, the condition which are temperature and pressure is changed. the melting condition in temperature and pressure is adapted identically. After melting, it's joint is tested as intension. The result is that the effect of temperature in intension is more effective than pressure. In 210℃, 20㎏/㎠ condition, the melting intension has the highest. Compare to the Butt melting joint and the Saddle melting joint, the former was 214㎏/㎠ and the latter was 50㎏/㎠(bead 2~3㎜) and 73㎏/㎠(bead 5~7㎜). It means that the Butt melting method has more intensive than saddle. Consequently, the result shows that the liability and safety when PE pipe melting method is used will improve in pipe installation.
전흥원,지상철,단형광 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.1
The antiinflammatory and antirheumatic activities of a 3% ketoprofen gel (ID-GEL) were evaluated using carrageenan-induced paw edema method and adjuvant-induced arthritis method, respectively, after its transdermal administration of 50 ㎎ on rat paws in reference to existing transdermal preparations containing 3% ketoprofen and other nonsteroidal antiinflammatory drugs (NSAIDs). The % inhibition of carrageenan-induced edema by ID-GEL was 56.2-65.0%, close to the maximum inhibition obtainable with this model, while the % inhibition by existing 3% ketoprofen gels and other NSAID transdermal preparations were 33.8-47.7% and 18.7-29.2%, respectively. ID-GEL had a pronounced antirheumatic activity in both preventive and curative studies with adjuvant-induced arthritis in rats in respect with the inhibition of edema, arthritis score and weight gain, in reference to existing 3% ketoprofen gel.
전흥원,단현광,지상철 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.1
In order to reduce the systemic side effects and gastrointestinal irritation of ketoprofen after its oral administration, it was formulated as a 3% ketoprofen gel (ID-GEL) with Pluronic F-127. The pharmacokinetic characteristics of ID-GEL was evaluated following its transdermal application on the dorsal skin of rats at the dose of 9 ㎎/㎏ in reference to those of existing 3% ketoprofen gels. Even though the maximum concentration of 810 ng/㎖ was reached at 6 hrs postdose, the plasma concentration was kept almost constant until 24 hrs postdose, which suggested that ketoprofen was released continuously from the gel during this period. The bioavailability of ID-GEL was two times higher than those of existing 3% ketoprofen gels, based on the calculated area under the plasma concentration-time curves after the percutaneous administration.
생체시료내 약물의 HPLC 분석법에 대한 유효성 검토방법
전흥원,지상철 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.3
An HPLC assay method of a drug to be applied to the pharmacokinetic studies of the drug should be completely validated. The validation process for an HPLC assay method in a biological sample was discussed using the data obtained from the development of HPLC method for the simultaneous quantitation of verapamil and norverapamil in human serum. The validation criteria included were specificity, linearity, accuracy, precision, sensitivity, recovery, drug stability, and ruggedness of an assay method.
Validation Process of HPLC Assay Methods of Drugs in Biological Samples
지상철,전흥원,Chi, Sang-Cheol,Jun, H.-Won 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.3
An HPLC assay method of a drug to be applied to the pharmacokinetic studies of the drug should be completely validated. The validation process for an HPLC assay method in a biological sample was discussed using the data obtained from the development of HPLC method for the simultaneous quantitation of verapamil and norverapamil in human serum. The validation criteria included were specificity, linearity, accuracy, precision, sensitivity, recovery, drug stability, and ruggedness of an assay method.
HPLC 법에 의한 혈중 Clofibric Acid 의 정량법 개선 및 응용
차봉진(Bong - Jin Cha),민신홍(Shin - Hong Min),전흥원(H . Won Jun) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4
An improved procedure for the quantitation of clofibric acid in human serum by high performance liquid chromatography with fluorescence detection was developed. The assay is simple, accurate, reproducible and was validated at the concentrations of 0.3-100 ㎍/㎖ in human serum. Regression analysis for the standard plots obtained from intra-day and inter-days studies indicated excellent linearity(r>0.999) and reproducibility(CV, 3.4-5.0%). The pharmacokinetic profile in human could be obtained over seven times the elimination half-life after a single oral dose of 500㎎ of clofibrate.