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흰쥐에 Toluene과 Alcohol의 병행투여가 Toluene 대사 효소활성에 미치는 영향
윤종국(Chong-Guk Yoon),전재현(Jai-Hyun Jeon),신중규(Joong-Kyu Shin) 한국식품영양과학회 1996 한국식품영양과학회지 Vol.25 No.6
흰쥐를 대조군과 체중 100g 당 ethanol 0.3ml를 1일 1회 4일간 복강내로 투여한 실험군, 체중 100g 당 toluene 0.3ml를 1일 1회 4일간 복강내로 투여한 실험군 및 ethanol 투여 2시간 후 toluene을 투여한 군으로 나누어 실험을 행하여 다음과 같은 결과를 얻었다. Alcohol 투여군, toluene 투여군 모두 간 microsomal aniline hydroxylase(AH) 및 aminopyrine demethylase(AD) 활성도가 대조군 보다 유의한 증가를 보였다. Toluene과 ethanol의 병행군은 toluene 투여군 보다 AH 및 AD 활성도가 다소 낮게 나타나는 경향을 보였다. 간조직 중 benzylalcohol dehydrogenase 활성도 역시 alcohol 및 toluene 투여군 모두 대조군에 비하여 높게 나타났으며 toluene과 alcohol의 병행투여군은 toluene 투여군 보다 본 효소 활성도가 다소 낮게 나타나는 경향을 보였다. 한편 간조직 중 benzaldehyde dehydrogenase 활성도는 alcohol 및 toluene 투여군 모두 대조군에 비하여 증가되는 경향을 보였으며 alcohol과 toluene의 병행 투여군은 toluene 투여군 보다 유의한 감소를 보였다. 또한 간조직 중 xanthine oxidase 활성도는 alcohol과 toluene 병행 투여군이 toluene 투여군 보다 유의하게 증가되었다. 이상 실험성적을 종합해 볼 때 alcohol의 전처치는 toluene 대사 효소 활성도를 억제시켜 toluene대사에 영향을 미칠 것으로 생각된다. To elucidate the effect of acute ethanol pretreatment on some toluene metabolizing enzyme activities, rats were divided into 4groups: control, alcohol-treated, toluene-treated, rat's and toluene-treated rats pretreated with ethanol. The alcohol or toluene-treated rats showed the significantly increased activities of hepatic aniline hydroxylase(AH) and aminopyrine demethylase(AD) compared to the control group. And the toluene-treated rats pretreated with ethanol showed somewhat decreased tendency of these enzyme activities compared to only toluene-treated rats. Liver benzylalcohol or aldehyde dehydrogenase activities were higher in alcohol or toluene-treated rats than those of the control group. The toluene-treated rats showed the decreased tendency of benzylalcohol dehydrogenase activities by the pretreatment of alcohol. Furthermore, toluene treated-rats showed the markedly decreased activity of benzaldehyde dehydrogenase by the ethanol pretreat-ment. On the other hand, hepatic xanthine oxidase activity in toluene-treated animals pretreated with ethanol was significantly higher than those of the toluene alone-treated rats. These results indicate that the combination of ethanol with toluene treatment for a short period of time possibly results in decreased activity of some toluene metabolizing enzymes in rats.
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흰쥐에 Toluene과 Alcohol의 병행투여가 간 손상에 미치는 영향
전재현,임영숙,윤종국 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.3
To evaluate an effect of acute ethanol pretreatment on the liver injury in toluene-treated rats, toluene(50% in olive oil) was intraperitoneally given four times at 0.3㎖/100g body weight at interval of one day to the ethanol-pretreated rats(0.3㎖ of 50%/100g body weight). The increasing rate of liver weight per body weight(%), serum levels of alanine aminotransferase (ALT) activity, liver lipid peroxide content was higher in toluene treated rats pretreated with ethanol than those treated with toluene alone. Concomitantly the hepatic glucose-6-phosphatase activity was increased whereas glutathione content was decreased by ethanol pretreatment before toluene administration in rats. In case of direct administration of acetaldehyde or benzaldehyde to the rats, the liver weight per body weight(%) and serum levels of ALT activity were almost higher than the control group. There results indicate that the toluene treated rats showed the reversible injury of liver and intensified, however, by the ethanol treatment.
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