Phytoestrogens과 골대사

전균호,강병문 대한골다공증학회 2013 Osteoporosis and Sarcopenia Vol.11 No.3

Although most gynecologists had prescribed estrogen with or without progestin for their menopausal patients before the publication of Women’s health Initiative (WHI) trial findings, only 35 to 40% of women ever started hormone therapy (HT) and many discontinued it, because of perceived side effects and discomfort. HT will not likely to be regularly prescribed in the future given the recommendations by several groups against long-term use for chronic diseases after the release of the findings of the WHI. Consequently, many postmenopausal women have turned to botanical dietary supplements containing phytoestrogen as an alternative to HT. Although there are numerous studies in the literature over the last decade trying to address the efficacy of phytoestrogens on bone health in animal models and in humans, the efficacy of phytoestrogens as bone-protective agents in vivo remains unclear. Differences in the bioactivities of individual phytoestrogens, differences in bioavailability and metabolism of phytoestrogens within different study populations, and imprecise reporting of the form and dose of phytoestrogens provided in intervention studies may have leaded to the disparity in study results. However, the preventive effect of phytoestrogens for bone loss is promising. This review discusses the effects of phytoestrogens on bone metabolism and their roles on the prevention and treatment of postmenopausal osteoporosis.

생식내분비학 : 사춘기 발달장애를 유발하는 질환들의 감별진단

전균호,김성훈 대한산부인과학회 2008 연수강좌 Vol.39 No.-

자궁내막에 발생한 점막 연관 림프조직 (MALT) 림프종 1예

전균호,조현진,박성균,김천복,김대연,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

Non-Hodgkin's 림프종의 약 40%는 결절외(extranodal) 림프종으로 대개 위장관에서 발생하며 이들 중 점막 연관 림프조직(mucosa-associated lymphoid tissue: MALT)에서 기원한 림프종은 MALT 림프종으로 분류된다. 위 외의 부위에서 원발성으로 발생하는 MALT 림프종은 매우 드물지만 실제 거의 모든 신체 장기에 발생하는 것으로 알려져 있는데, 가장 흔한 부위인 위 외에도 폐, 갑상선, 침샘, 눈물샘에 발생하고, 드물게 안구, 유방, 방광, 신장, 흉선 등에도 보고된 바 있다. MALT 림프종은 오랜 기간동안 원격 전이하지 않고 국소 병변으로 남아 있는 특징이 있어 치료 방향 또한 국소 병변의 치료에 집중되며, 예후도 림프절 기원의 림프종에 비해 양호한 것으로 알려져 있다. 본 저자 등은 자궁 내막에 원발성으로 발생한 MALT 림프종 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하고자 한다. Mucosa associated lymphoid tissue (MALT) lymphoma can rarely develop primarily in extranodal sites other than stomach which is the most common site for it. Other rare primary sites are small intestine, colorectum, esophagus, lung, thyroid, salivary gland, lacrymal gland, breast and skin. MALT lymphoma represents a distinct clinicopathologic features: it is usually localized to their original site for a long time and shows much more favorable prognosis than lymphoma at other site, but some MALT lymphoma can arise simultaneously or successively in different organ or give rise to another MALT lymphoma of other organ and can be multifocally disseminated or recurred. We report a very rare case of high grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) of the uterine endometrium, which was confirmed by immunohistochemical assay.

다낭성난소증후군 환자에서 체질량지수가 체외수정시술에 미치는 영향

전균호 ( Gyun Ho Jeon ),김정훈 ( Chung Hoon Kim ),김유진 ( Eu Gene Kim ),김소라 ( So Ra Kim ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.1

Objective: This study was performed to evaluate the effect of body mass index (BMI) on the outcome of in vitro fertilization and embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS). Methods: Ninety-six patients with PCOS who completed their first cycle of IVF-ET were included in this retrospective study. All patients were stimulated by GnRH antagonist multi-dose protocol. The patients were divided into one of two groups on the basis of BMI ≥23 kg/m2 vs. BMI <23 kg/m2, and their outcome of IVF-ET was compared. Additionally the patients with BMI ≥23kg/m2 were divided into patient group with 23 ≤BMI <25 kg/m2 and patient group with BMI ≥25 kg/m2, and these three groups were also compared in regard to the outcome of IVF-ET. Results: The total amount and duration of rhFSH administration were significantly higher in PCOS women with BMI ≥23 kg/m2 than in those with BMI <23 kg/m2 (P<0.001 in both). The implantation rate was significantly lower in women with BMI ≥23 kg/m2 (17.4% vs 7.8%, P=0.024). When compared three group divided on the basis of BMI <23 kg/m2 vs BMI 23~25 kg/m2 vs BMI ≥25 kg/m2, similar results were showed in women with BMI ≥25 kg/m2, although implantation rate in women with BMI ≥25 kg/m2 was lower with borderline significance (P=0.069). Conclusion: Obesity (BMI ≥23 kg/m2) has a detrimental effect on implantation rate and is associated with the increased total amount and duration of rhFSH administration for ovarian stimulation in IVF-ET cycle. Consequently BMI may be a predictor for IVF outcomes in patients with PCOS.

Clinical and Laboratory characteristics of female precocious puberty(초)

전균호 ( Gyun Ho Jeon ),( So Ra Kim ),( Sung Hoon Kim ),( Hee Dong Chae ),( Chung Hoon Kim ),( Byung Moon Kang ) 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-

폐경 여성에서 혈중 에스트라디올과 관상동맥 석회화 사이의 연관성: 예비 보고

전균호 ( Gyun Ho Jeon ),김성훈 ( Sung Hoon Kim ),김소라 ( So Ra Kim ),채희동 ( Hee Dong Chae ),김정훈 ( Chung Hoon Kim ),강병문 ( Byung Moon Kang ) 대한폐경학회 2010 대한폐경학회지 Vol.16 No.1

연구목적: 폐경 여성에서 관상동맥 석회화와 혈청 에스트라디올 수치 사이에 연관성이 있는지 평가하고자 하였다. 연구재료 및 방법: 건강증진센터에서 건강 검진을 위해 관상동맥 컴퓨터 단층촬영술을 시행 받은 162명의 폐경 여성을 대상으로 의무기록을 검토하였다. 관상동맥 칼슘치 (coronary artery calcium score, CACS) 100이상과 100미만의 여성들 간의 혈청 에스트라디올 수치, 관상동맥질환 위험인자들, 요추부와 대퇴골 경부의 골밀도, 현재 호르몬 치료 상태에 관하여 분석하였다. 결과: CACS 100이상의 여성과 비교하여 CACS 100미만의 여성에서는 혈청 에스트라디올 수치는 유의하게 높은 것으로 나타났고 (27.34±2.96 vs. 13.31±1.10 pg/ml, P=0.030), 평균나이가 유의하게 낮았다 (57.63±0.44 vs. 61.88±1.90, P=0.037). 또한 CACS 100미만의 여성에서 혈청 에스트라디올 20 pg/ml 이상의 빈도 역시 CACS 100이상의 여성들에서 보다 더욱 높은 경향을 보였고 (42.25 vs. 0%, P=0.022), 고혈압의 빈도는 보다 낮은 경향으로 나타났다(28.17 vs. 62.50%, P=0.053; borderline significant). 하지만, 다중 회귀 분석에서는 고혈압만이 CACS와 유의한 관계가 있는 것으로 나타났다 (OR 5.831 [95% CI 1.035 to 32.85], P=0.046). 결론: 폐경 여성에서 혈청 에스트라디올 농도는 관상동맥 석회화의 정도와 연관성이 있을 것으로 기대된다. Objectives: To estimate whether coronary artery calcification in postmenopausal women is associated with serum estradiol level. Methods: The present study retrospectively examined the clinical records of 162 postmenopausal women who visited the Health Promotion Center for a routine checkup and underwent a multidetector CT scan of the heart. Serum estradiol level, coronary heart disease (CHD) risk factors, current hormone therapy status, and BMD of the lumbar vertebrae and femoral neck were analyzed in women with coronary artery calcium score (CACS) ≥100 and <100. Results: Compared to women with higher CACS (≥100), women with lower CACS (<100) had a significantly higher level of serum estradiol (27.34±2.96 vs. 13.31±1.10 pg/ml, P=0.030) and lower mean age (57.63±0.44 vs. 61.88±1.90, P=0.037). Women with CACS <100 were significantly more likely to have a serum estradiol level greater than 20 pg/ml (42.25 vs. 0 %, P=0.022) and lower prevalence of hypertension (28.17 vs. 62.50%, P=0.053, borderline significant). However, multiple logistic regression analysis showed that any factors did not have a significant association with CACS except hypertension (OR 5.831 [95% CI 1.035 to 32.85], P=0.046). Conclusion: Serum estradiol level might be associated with the degree of calcification of coronary artery in postmenopausal women. (J Korean Soc Menopause 2010;16:16-22)

폐경여성에서 녹내장 발생과 혈중 에스트라디올 농도와의 관계

전균호 ( Gyun Ho Jeon ),조현진 ( Hyun Jin Cho ),전성욱 ( Sung Wook Chun ),지용일 ( Yong Il Ji ),정철회 ( Chul Hoi Jeong ),서민희 ( Min Hee Suh ),이주은 ( Joo Eun Lee ) 대한폐경학회 2013 대한폐경학회지 Vol.19 No.2

연구목적: 폐경여성에서 녹내장 발생과 혈중 에스트라디올 (estradiol, E2)농도와의 관련성을 알아보고자 하였다. 연구재료 및 방법: 산부인과 외래를 방문한 30명의 폐경여성을 대상으로 혈중 E2 농도, 폐경 관련 임상 지표, 안압, 빛 간섭 단층촬영 등의 녹내장 관련 임상 지표를 측정하였다. 안과적 선별 검사 결과에 따라 녹내장 의심 군으로 분류되면 정밀검사를 시행하여 녹내장 여부를 확진 하였다. 모든 환자들을 녹내장 의심 군과 녹내장 비의심군으로 분류한 후 두 군 사이의 혈중 E2 농도 및 지질 농도, 골밀도 등의 폐경 관련 임상 지표들을 비교 분석하였다. 결과: 전체 30명 중 녹내장 의심군으로 분류된 환자가 8명 (26.7%)였으며, 이중 1명이 치료가 필요한 녹내장, 2명이 초기 녹내장으로 진단되었다. 녹내장 의심 군과 비교하여 녹내장 비의심군에서 혈중 E2 농도가 더 높은 것으로 측정되었지만, 통계적인 유의성은 없었다 (19.40 ± 4.79 vs. 13.95 ± 4.55 pg/mL, P = 0.525). 혈중 E2 농도가 높은 군 (≥ 20 pg/mL)과 낮은 군 (< 20 pg/mL) 사이의 녹내장 의심자의 빈도 또한 유의한 차이가 없었고 (25.0 vs. 27.3%, P = 0.645), 녹내장 의심 군과 비의심군간의 다중 로지스틱 회귀분석을 시행한 결과에서도 녹내장 의심 군과의 유의한 연관성이 있는 지표는 역시 없었다. 결론: 폐경여성에서 빛 간섭 단층 촬영과 같은 정밀 선별검사를 시행한 결과 일반적으로 알려진 비슷한 연령대의 녹내장 유병 율보다 높은 빈도에서 녹내장 환자를 발견할 수 있었다. 혈중 E2 농도와 안압 및 녹내장 발생 위험간의 통계적 유의성은 확인할 수 없었다. Objectives: To investigate the occurrence of glaucoma and association with the serum estradiol (E2) level in postmenopausal women. Methods: We evaluated the serum E2 level, female reproductive factors and glaucoma related risk factors including intraocular pressure and optical coherence tomography (OCT) findings in 30 postmenopausal women who visited Obstetrics and Gynecology outpatient clinic. Patients who showed abnormal findings on the glaucoma screening test were classified to the glaucoma suspect group (group-G), and underwent a glaucoma confirmatory test. Serum E2 level, female reproductive and other menopausal health-related factors such as lipid profiles and bone mineral densities were analyzed in the group-G and non glaucomatous group (group-N). Results: Eight out of thirty participants (26.7%) were classified to the group-G. One of them was diagnosed as having glaucoma that required treatment, and the other two were found to have early glaucomatous changes. Compared to the group-G, the group-N had a higher level of serum E2 (19.40 ± 4.79 vs. 13.95 ± 4.55 pg/mL) The difference, however, was not statistically significant (P = 0.525). The proportion of glaucoma suspect patients in the groups with a higher serum E2 level (≥ 20 pg/mL) and a lower serum E2 level (< 20 pg/mL) was similar (25.0 and 27.3%, P = 0.645). Multiple logistic regression analysis showed that no female reproductive factors were associated with the risk of glaucoma. Conclusion: Comprehensive glaucoma screening using an OCT in postmenopausal women could detect more glaucoma patients than prevalence in the similar age group. Statistical significance was not found in the association between serum E2 level and the risk of glaucoma. (J Korean Soc Menopause 2013; 19:106-111)

The outcome of in vitro fertilization and embryo transfer according to body mass index of patients with polycystic ovary syndrome

전균호 ( Gyun Ho Jeon ),( Eu Gene Kim ),( So Ra Kim ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang ),( Chung Hoon Kim ) 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-

Management of Perinatal Ovarian Cysts: 20 year experience at a single institution (초)

전균호 ( Gyun Ho Jeon ),( Hyuk Jae Kang ),( Sung Hoon Kim ),( Hee Dong Chae ),( Chung Hoon Kim ),( Byung Moon Kang ) 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-

Klippel-Trenaunay 증후군 여성에서의 임신

전균호 ( Gyun Ho Jeon ),김연미 ( Yeon Mee Kim ),전성욱 ( Sung Wook Chun ),조현진 ( Hyun Jin Cho ),지용일 ( Yong Il Ji ),정철회 ( Chul Hoi Jeong ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2

The Klippel-Trenaunay syndrome is rare congenital disease characterized by a triad of cutaneous vascular malformations, varicose veins, and hypertrophy of bone and soft tissue. Although several cases of pregnancy in women with Klippel-Trenaunay syndrome were reported as there may be increased risk of pregnancy- and/or delivery-associated complications such as varicosities, thromboembolism and hemorrhage, there is little general information regarding how to deal with pregnancy in patients with Klippel-Trenaunay syndrome and their obstetric outcome. We describe the case of a woman suffering from Klippel-Trenaunay syndrome delivering a healthy child with a brief review of concerned literature.