순회 판매원 문제 해결을 위한 개미집단 최적화 알고리즘 개선

장주영,김민제,이종환 한국산업경영시스템학회 2019 한국산업경영시스템학회지 Vol.42 No.3

It is one of the known methods to obtain the optimal solution using the Ant Colony Optimization Algorithm for the Traveling Salesman Problem (TSP), which is a combination optimization problem. In this paper, we solve the TSP problem by proposing an improved new ant colony optimization algorithm that combines genetic algorithm mutations in existing ant colony optimization algorithms to solve TSP problems in many cities. The new ant colony optimization algorithm provides the opportunity to move easily fall on the issue of developing local optimum values of the existing ant colony optimization algorithm to global optimum value through a new path through mutation. The new path will update the pheromone through an ant colony optimization algorithm. The renewed new pheromone serves to derive the global optimal value from what could have fallen to the local optimal value. Experimental results show that the existing algorithms and the new algorithms are superior to those of existing algorithms in the search for optimum values of newly improved algorithms.

뇌졸중 환자군의 Warfarin Nomogram 설정을 위한 실제 처방전 평가

장주영,고경미,윤지연,한옥연,임성실,Jang, Ju-Young,Ko, Kyung-Mi,Yoon, Ji-Yeon,Han, Ok-Yeon,Lim, Sung-Cil 대한약학회 2009 약학회지 Vol.53 No.2

Warfarin is the most widely used oral anticoagulant in the world but maintenance of proper therapeutic range and prevention of adverse drug events always need to be careful. Especially, in Korea, warfarin dosing for patients with cerebral infarction is currently based on the nomogram which is done by foreign clinical trials not for the Korean. Therefore we evaluate warfarin dose of patients in the neurology and eventually get the base data of warfarin nomogram for Korean with stroke. We performed this study retrospectively on reviewing the medical charts to evaluate the prescribed loading dose (LD) and maintenance dose (MD) of warfarin and each responding International Normalized Ratio (INR) with any bleeding adverse drug reaction including of patient's characteristics for total 75 patients with stroke in the department of neurology of Kangnam ST. Mary's Hospital from January 2005 to June 2008. All evaluated patients should not be treated with warfarin in the past at all and should be initiated warfarin therapy first.ly at this time. All evaluated patients were divided as two classes by wafarin LD which is; 1) HDG - a high loading dosing group prescribed over 5mg, and 2) LDG - a low loading dosing group prescribed 5mg or below. As a result, average LD was $9.34{\pm}0.22$ mg (p=0.000) in HDG and $4.25{\pm}0.39$ mg (p=0.000) in LDG. Average baseline INR was $0.91{\pm}0.05$ (p=0.161) in HDG and $1.26{\pm}0.14$ (p=0.002) in LDG. On the first and second week, daily MD was $4.21{\pm}0.14$ mg (p=0.000) and $2.96{\pm}0.19$ mg (p=0.696) in HDG and also in LDG, $2.95{\pm}0.29$ mg (p=0.000) and $3.14{\pm}0.36$ mg (p=0.696). Also average reacting daily INR was respectively $2.53{\pm}0.12$ (p=0.141) and $2.51{\pm}0.16$ (p=0.678) in HDG, and in LDG, $2.11{\pm}0.17$ (p=0.141) and $2.42{\pm}0.14$ (p=0.678). After the second week, INR was not measured in regularly. Also most of underlying diseases were hypertension (n=38), diabetes mellitus (n=14), dyslipidemia (n=8) in order. Four ADRs with simple hemorrhage were occurred and those were due to drug interaction by comedication. In the conclusion, proper starting LD for Korean with stroke is 10 mg if baseline INR is around 1.0 or 5 mg if over 1.3. Proper MD need to be more evaluated in the future for setting up warfarin nomogram to make prospective study.

The Usefulness of the Tuberculosis Skin Test and the Interferon-gamma Release Assay in the Diagnosis of Latent Tuberculosis Infection in South Korea

장주영,박인원,최병휘,최재철 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.-

Objectives: South Koreans receive the bacillus Calmette-Guerin (BCG) vaccination, which influence the result of the tuberculin skin test (TST); however, only a few studies have described the usefulness of the TST and interferon-g release assay (IGRA) for diagnosing latent TB infection (LTBI). Therefore, our aim was to determine the usefulness of the TST and IGRA for diagnosing LTBI in a household contacts investigation. Methods: We reviewed the 329 household contacts who visited Chung-Ang University Hospital (Seoul, Korea) from May 1, 2011 to February 28, 2014. To evaluate the effectiveness of TST and IGRA for the diagnosis of LTBI, we examined the concordance rate between the two tests, based on age. We also evaluated the risk factors for LTBI. Results: The concordance rate between the two tests in individuals 0-24 years, 25-54 years, and over 55 years were 82.6% (k = 0.64, p < 0.01), 68.9% (k = 0.40, p < 0.01), and 68.4% (k = 0.35, p < 0.01), respectively. The ratio of positive TST to negative IGRA was higher in individuals 25-44 years old, whereas the ratio of negative TST to positive IGRA was higher in individuals older than 55 years old. Based on the TST, the risk factor for LTBI was a cavity (p < 0.01). When using IGRA, the risk factors were contact time (p = 0.04) and age over 55 years old (p = 0.02). Conclusion: The concordance rate between TST and IGRA was not good after the age of 25 years. The IGRA test reflects the known risk factors more exactly.

기후변화와 정의로운 전환 해외 노조 사례

장주영 한국노동사회연구소 2008 노동사회 Vol.133 No.-

난민 유사상황에 대한 대안적 방식의 국제적 보호

장주영,김희주,김수경 국회입법조사처 2022 입법과 정책 Vol.14 No.1

There have been growing needs for international protection for those not meeting the refugee definition in the 1951 Convention. Consequently, providing alternative protection for them is required based on international human rights obligations. The current study aimed to introduce Korean readers to complementary forms of protection―subsidiary, complementary, and temporary protection and explored how the concepts were implemented in Sweden, Ireland, Canada, Australia, and the U.S.A. Implications for Korean humanitarian protection were provided.

결혼이주민 원가족 초청에 대한 일반인의 태도

장주영 가정과삶의질학회 2023 가정과삶의질학회 학술발표대회 자료집 Vol.2023 No.6

교내 흡연에 의한 교실 내 공기 오염에 관한 학생들의 인식에 대한 연구

장주영,주윤기,이종서,박연수 한국환경교육학회 2013 한국환경교육학회 학술대회 자료집 Vol.2013 No.12

두 개의 이득모드로 동작하는 광대역 저잡음 증폭기 설계

장주영,최현석,강소영,박철순 한국ITS학회 2010 한국ITS학회 학술대회 Vol.2010 No.1

기관 또는 기관지 협착을 가진 소아에서의 스텐트 적용

장주영,김효빈,이소연,김자형,박성종,신지훈,홍수종 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.5

Purpose:In adults, endoscopic tracheobronchial balloon dilatation and stenting have become valuable methods to establish and maintain an adequate airway lumen when tracheomalacia or neoplastic growth compromise the airways. But in children, only a few cases were reported due to technical problems. We report six children who were treated with stent implantation and describe the use and safety of airway stents. Methods:Six patients with severe airway obstruction were treated. We investigated the underlying medical problems, stenotic site, symptomatic improvement and complications, and the size and location of stent. Results:The median age of the six patients was 21 months. Three of them were mechanically ventilated and one had an endotracheal tube to maintain the patency of airway. Diagnoses were:congenital tracheal stenosis with or without bronchomalacia, granulation tissue formation after right upper lobectomy by bronchial carcinoid or after prolonged intubation, endobronchial tuberculosis, and airway compression by mediastinal undifferentiated sarcoma. Nitinol stents were implanted in the airway guided by bronchoscopy and fluoroscopy simultaneously. Three cases were placed in trachea, the others were in the bronchus. After stent implantation, all patients showed marked improvements of their airway obstructive symptoms. Four patients are doing well, although two expired due to underlying diseases. Four patients had granulation tissue formation around stents, but that was tolerable after removing the stent. Conclusion:We suggest that the use of expandible metallic stent implantation can offer safe therapeutic option even in extremely severe, life threatening and inoperable airway stenosis in children. 목 적 : 성인에서는 기관연화증이나 악성종양에 의한 기도폐쇄 시에 기관지내시경을 이용한 풍선확장술과 스텐트 적용이 일반적으로 고려되고 있으나, 소아에서는 그 예가 적으며 최근 수술적 치료가 불가능한 경우에 스텐트를 적용한 몇몇 보고가 있었다. 저자들은 기관 또는 기관지 협착을 가진 소아에게 스텐트를 적용한 6례를 경험하였기에 보고하고자 한다.방 법 : 1998년부터 2004년까지 서울아산병원에서 스텐트를 적용한 소아 6명의 의무기록을 검토하였다. 대상 환아의 연령과 진단명, 시술 후 호흡기 증상의 호전 여부와 스텐트 종류와 위치, 추적관찰 중에 발생한 합병증에 대하여 조사하였다.결 과 : 스텐트 삽입을 시행한 환아의 중간연령은 21개월이었으며 3명은 인공환기요법을 시행하고 있었고 1명은 기관내 삽관술만 시행하였다. 진단명은 선천성 기관협착 1례, 선천성 기관협착과 동반한 기관지 연화증 1례, 기관지 칼시노이드로 우상엽 절제술을 시행한 이후에 생긴 기관지내 육아조직 형성 1례, 기관지 결핵으로 인한 기관지내 육아조직 형성 1례, 종격동의 미분화육종으로 인한 기도압박 1례, 장기간의 기관내 삽관 이후 발생한 육아조직에 의한 기관지협착이 1례였다. 스텐트를 삽입한 위치는 기관이 3례, 좌측 주기관지가 2례, 우측 기관지가 1례였고 스텐트는 Nitinol 스텐트였다. 스텐트 적용 이후 모든 예에서 호흡기 증상의 호전을 보였으며 1례에서 인공호흡기 치료를 중단할 수 있었고 1례에서 기관내 삽관을 제거하였다. 중간 추적기간은 21개월이었고 2례는 기저질환에 의해 사망하였으며 4례는 스텐트 제거 이후에 특별한 호흡기 증상없이 잘 지내고 있다. 추적관찰 기간이 2개월 이하이었던 2례를 제외하고 모든 예에서 육아조직이 형성되는 합병증이 있었고 1례는 반복적인 폐렴으로 스텐트를 제거하였다.결 론:기관 또는 기관지 협착을 가진 소아에 있어서 수술적 치료에 어려움이 있는 경우 또는 선천성 기관협착 환아에서 수술 전에 풍선확장술과 기관지내시경을 이용한 스텐트 삽입술은 안전하고 효과적인 방법으로 고려할 수 있겠다.

4,5,6,7- Tetrahydroisoxazolo [ 3,4- c ] pyridine 유도체의 새로운 합성

장주영,이영주,김형진 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1997 No.0