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만성 C형 간염에서 Fas/Fas Ligand에 의한 간세포 자멸사
장우임 ( U Im Chang ),한준열 ( Joon Yeol Han ),김진일 ( Jin Il Kim ),최종영 ( Jong Young Choi ),조세현 ( Se Hyun Jo ),한남익 ( Nam Ik Han ),윤승규 ( Seung Kew Yoon ),양진모 ( Jin Mo Yang ),안병민 ( Byung Min Ahn ),김재광 ( Jae Kwa 대한소화기학회 2003 대한소화기학회지 Vol.41 No.4
Background/Aims: In chronic hepatitis C, the Fas/Fas ligand-mediated apoptosis is involved in the hepatic injury. The soluble forms of Fas and Fas ligand have been detected in serum and shown to inhibit Fas-mediated apoptosis. In the present study, we evaluated the relationships between the serum level of soluble Fas/Fas ligand and their histological and biochemical activities to elucidate the role of Fas system in pathogenesis of chronic hepatitis C. Methods: Liver biopsy samples were graded according to the Knodell`s Histologic Activity Index and immunohistochemically stained for Fas and Fas ligand. Serum soluble Fas and Fas ligand levels of chronic hepatitis C patients were compared with those of control group. These levels were compared with histological activities, ALT levels and Fas expression grades. Results: Serum soluble Fas levels in patients with chronic hepatitis C were higher than those in the control group, although it is not statistically significant. Soluble Fas level in patients with moderate and marked intralobular inflammation were higher significantly than those in control group. There was a positive relationship between the grade of Fas expression and HAI score. Conclusions: These findings suggest the possibility that the concentration of soluble Fas is associated with severity of intralobular inflammation in patients with chronic hepatitis C. (Korean J Gastroenterol 2003;41:205-301)
만성 C형 간염 환자에서 HCV Core Antigen Assay의 임상적 유용성
김창욱 ( Kim Chang Ug ),장우임 ( Jang U Im ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),조세현 ( Jo Se Hyeon ),양진모 ( Yang Jin Mo ),한준열 ( Han Jun Yeol ),안병민 ( An Byeong Min ),최상욱 ( Choe Sang Ug ),이영석 ( Lee Y 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 만성 C형 간염에서 바이러스 정량분석은 치료대상자 선정, 치료판정 예측에 이용되고 있다. 최근 말초혈액에서 HCV core antigen을 단일클론항체(monoclonal antibody)를 이용한 ELISA기법으로 비교적 간편하게 측정할 수 있게 되었으며, PCR 법에 의한 HCV RNA 정량분석과 임상적 유용성이 비교되고 있다. 저자들은 만성 C형 간염환자에서 인터페론과 리바비린 병합치료 전과 후 HCV core antigen assay의
뼈전이에 대한 방사선 치료 이후 압스코팔 효과로 폐전이 호전을 보인 간세포암 1예
송도선 ( Do Seon Song ),장우임 ( U Im Chang ),안호정 ( Ho Jung An ),김성환 ( Sung Hwan Kim ),양진모 ( Jin Mo Yang ) 대한간암학회 2017 대한간암학회지 Vol.17 No.2
The abscopal effect is a rare phenomenon that characterized by tumor regression of untreated metastatic lesions after a local radiotherapy. The mechanisms of abscopal effect are speculated to be associated with cytokine release and host immune system. In this case, we report a case of abscopal effect in a 64-year-old male with hepatocellular carcinoma with lung and bone metastasis, who had complete response in the lung after receiving radiation to the metastatic bone lesions. (J Liver Cancer 2017;17:168-173)
곽승기(Seung Ki Kwok),장우임(U Im Chang),이태규(Tae Kyu Lee),추교영(Kyo Young Choo),김진일(Jin Il Kim),박수헌(Soo Heon Park),한준열(Joon Yeol Han),김재광(Jae Kwang Kim),정규원(Kyu Won Chung),선희식(Hee Sik Sun) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3
Tuberculosis of the abdominal wall is relatively uncommon and most cases were caused by a spread of the infection from tuberculous abdominal lymph nodes. Autopsy studies have shown abdominal wall involvement in less than 1% of patients who died of tuberculosis. We have experienced a case of the tuberculous abscess in the abdominal wall. A 21-year-old woman was admitted for the evaluation of a soft mass at the right upper abdomen. A 15×5×4 cm sized abscess in the abdominal wall was detected by ultrasonogram and CT. Abscess was drained by ultrasonogram-guided aspiration. The confirmed diagnosis of tuberculous abscess was made by means of polymerase chain reaction of the aspirated fluid from the mass. The patient was successfully treated with anti-tuberculosis therapy of four drug regimens. To our knowledge, this is the first report of tuberculous abscess developed in the abdominal wall in Korea. (Korean J Gastroenterol 2001;38:220-223)
포스터 전시 : 간 ; 우심부전과 유전성 구형적혈구증으로 발생한 심한 간비종대 1예
서석민 ( Seo Seog Min ),김창욱 ( Kim Chang Ug ),박찬권 ( Park Chan Gwon ),남순우 ( Nam Sun U ),장우임 ( Jang U Im ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),최상욱 ( Choe Sang Ug ),정규원 ( Jeong Gyu Won ),선희식 ( Seon 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<증례> 54세 여자가 내원 12시간 전부터 발생한 발열과 오한, 우상복부 동통을 주소로 응급실로 내원하였다. 과거력상 어려서부터 비장종대가 있었으나 특별한 검사 없이 지내다가 내원 2년전 호흡곤란으로 심장비대와 담석이 있다는 사실을 알고 약물치료 중 이었다. 내원당시 혈압은 120/80㎜Hg, 맥박은 분당 100회, 호흡은 분당 24회, 체온은 38.0℃였고, 창백하면서 황달이 있었다. 심음은 규칙적이었으나 강도 4정도의 수축기 잡음이 심첨과 흉골좌측
곽재욱 ( Jae Wuk Kwak ),이강문 ( Kang Moon Lee ),정우철 ( Woo Chul Chung ),백창렬 ( Chang Nyol Paik ),장우임 ( U Im Chang ),김진동 ( Jin Dong Kim ),정성훈 ( Sung Hoon Jung ),양진모 ( Jin Mo Yang ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.5
Inflammatory bowel diseases (IBD) is heterogeneous, chronic relapsing disorder. Inappropriate and exaggerated immune response for the luminal antigen is known as a main pathogenesis. Genetic, infectious, and environmental factors are responsible for unbalanced immune response, but the definite pathogenesis is still unclear. Genetic factor is the most important role of all. That is based on high concordance rate of identical twins and family history. The incident rate and prevalence of IBD for the Asian population is relatively lower than Western population, and the lack of NOD2 or TLR4 genetic polymorphisms in Korea and Japanese population suggests the difference in genetic background between Asian and Western population. In Korea, the case of familial aggregation of IBD is pretty rare. We report a case of the daughter with ulcerative colitis and her mother with Crohn`s disease who have a -159C/T promoter polymorphism of CD14 gene for IBD. (Korean J Gastroenterol 2010;55:336-339)
연구논문 : 한국인 원발성 담즙성 간경변증의 임상 특징 및 예후
김경아 ( Kyung Ah Kim ),정숙향 ( Sook Hyang Jeong ),이정일 ( Jung Il Lee ),연종은 ( Jong Eun Yeon ),이헌주 ( Heon Ju Lee ),권소영 ( So Young Kwon ),장우임 ( U Im Chang ),민현주 ( Hyun Ju Min ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2
Background/Aims: This study investigated the clinical features and prognosis of primary biliary cirrhosis (PBC) in Korea. Methods: Clinical data of patients diagnosed as PBC between 1997 and 2008 at eight referral hospitals were analyzed retrospectively. PBC was diagnosed based on liver function tests, presence of serum antimitochondrial antibody (AMA), and histopathological findings. Results: In total, 251 patients (218 females, 33 males, mean age 54 years) were enrolled, and the mean follow-up duration was 33.5 months. At the diagnosis, 61% of the patients were asymptomatic, 12% had decompensated liver cirrhosis, and 98% were positive for AMA. The serum alkaline phosphate (AlP) level was 2.6 times the upper limit of normal, aspartate aminotransferase was 105 U/l, and bilirubin was 2.0 mg/dl. The mean Mayo risk score was 5.5, and the Child-Pugh class was A, B, and C in 79%, 19%, and 2% of the patients, respectively. Ursodeoxycholic acid (UDCA) was used for treatment in 88% of the patients, among which 70% exhibited biochemical responses defined as normalization or a >40% decrease in AlP at 6 months. Eight deaths occurred during the follow-up, the causes were variceal bleeding, hepatic failure, and sepsis. The overall 5-year survival rate was 95%. The poor prognostic factors were being older than 60 years, high bilirubin, low albumin, ascites, high Mayo risk score, Child-Pugh class C, and initial presence of hepatic decompensation. Conclusions: Most patients diagnosed as PBC were asymptomatic, and these patients had a favorable short-term prognosis. The prognosis of PBC was dependent on the initial severity of liver disease.
박영실 ( Young Sil Park ),정우철 ( Woo Chul Chung ),이강문 ( Kang Moon Lee ),이보인 ( Bo In Lee ),천지성 ( Ji Sung Chun ),장우임 ( U Im Chang ),양진모 ( Jin Mo Yang ),최규용 ( Kyu Yong Choi ),정인식 ( In Sik Chung ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.3
Gastric ulcer bleeding in neonatal period, mainly in preterm newborn babies or in neonates treated in intensive care units, is relatively frequent, However the occurrence of significant gastric ulcer bleeding in healthy full term infants is unusual. We experienced a case of massive upper gastrointestinal (GI) bleeding in a 3-day-old healthy full term infant. Endoscopic examination confirmed the presence of gastric ulcerations. Treatment was initiated with transfusion and histamine 2 receptor antagonist, and the clinical signs resolved. Mother`s serum antibody to Helicobacter pylori (H. pylori) was positive. We collected stool of the patient including other 17 infants in the intensive care unit. A highly sensitive semi-nested PCR for H. pylori DNA was performed, but all infants including the patient revealed negative. H. pylori infection is not related with upper GI bleeding in healthy full term infants. In conclusion, the diagnosis of upper GI bleeding in infant can be easily made by means of pediatric endoscopy, which is a simple and a well tolerated examination. (Korean J Gastroenterol 2006;48:210-214)
한국인 쯔쯔가무시병 환자에서 사이토카인 유전자의 다양성 조사
장우임,김수연,위성헌,김태규 대한감염학회 2010 감염과 화학요법 Vol.42 No.1
Background: Scrub typhus is caused by Orientia tsutsugamushi and can become severe and potentially life-threatening. It is suggested that specific host factors can modify the host response during O. tsutsugamushi infection. It is known that susceptibility and outcome of infectious disease are associated with genetic polymorphisms of some cytokines. Materials and Methods: Peripheral blood of 144 patients who were diagnosed with scrub typhus and of 311 unrelated healthy subjects were collected. A diagnosis of scrub typhus was made upon demonstration of a fourfold rise in antibody titer to O. tsutsugamushi in paired serum specimens in an indirect immunofluorescent (IFA) test. Genomic DNAs were extracted from peripheral mononuclear cells and genotypings for IL-1 (-511C/T), IL-1β (+3953T/C), IL-2 (-330T/G), IL-4 (-590C/T), IL-4R(-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A) and TNF-α (-308G/A) were performed simultaneously using PCR-SSP (sequence specific polymorphisms) assay. Results: The frequency of IL-1 (-511T/T) (OR=0.53, P<0.01) and IL-2 (-330T/T) (OR=0.56, P<0.01) were significantly decreased, but that of IL-2(-330G/G) (OR=4.49, P<0.01) was increased, in the scrub typhus patients compared to the healthy controls. And, there were no statistically significant differences in the genetic polymorphisms of IL-4 (-590C/T), IL-4Rα (-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A), TNF-α (-308G/A) genes, in the scrub typhus patients compared to the unrelated healthy controls. Conclusions: Cytokine polymorphisms in the IL-1 (-511T/T) and the IL-2 genes may influence the host response to O. tsutsugamushi.