여행상품 서비스질이 만족, 재방문, 추천의도에 미치는 영향

장병수 ( Byung Soo Jang ) (사)한국마이스관광학회(구 한국컨벤션학회) 2004 MICE관광연구 Vol.4 No.1

화장품 도포방법에 따른 피부 관리 전후의 상태 비교

장병수 ( Byung Soo Chang ),장아영 ( A Young Jang ),정다정 ( Da Jung Jung ) 대한미용학회 2018 대한미용학회지 Vol.14 No.2

In the present study, an attempt was made to compare and analyze the changes in facial skin condition after application of cosmetics using basic cosmetic application methods and air brush of modern women using a skin analyzer and a dermoscope. The results of facial skin moisture measurement showed that the control group and the experimental group maintained a sufficient moisture content in the foreheads, both cheeks and chin except the nose. According to the findings of skin sebum measurement, there was no significant change in the forehead, both cheeks and the chin of control group-1, and the nose decreased below normal after the experiment. The forehead, right cheek, and chin were normal in control group-2, and the nose increased from normal to above normal 4 weeks after the experiment. The forehead, left cheek, and chin of experimental group-1 increased to normal after the experiment, and the forehead, right cheek, nose and chin of experimental group-2 remained normal after the experiment. The results of pH measurement revealed that the forehead of the control group decreased from normal to below normal, while the remaining portion did not show any significant change. The experimental group-1 showed normal values in all portions and the experimental group-2 showed normal values in the nose and both cheeks. Dermoscopic studies showed that skin condition of the control group and the experimental group were different depending upon the concerned skin areas. The skin changes before and after the experiment turned out to be consistent with the result of the skin analysis using a skin analyzer. The experimental group showed an improvement in skin condition after the experiment. To sum up, skin care using air brush is effective for moisturizing as the fine particles ejected through the nozzle improve adhesion and durability to the skin. In order to maintain a balance between moisture and sebum in the skin, it is expected that our findings will be more effective if manual operation is performed after spraying with air brush.

Comparison of Enalapril Maleate Tablets on Bioavailability and the Time Course of Inhibition of Plasma Angiotensin-Converting Enzyme

장인진,장병수,신상구,신재국,노일근,이경훈,박찬웅,Jang, In-Jin,Jang, Byung-Soo,Shin, Sang-Goo,Shin, Jae-Gook,Rho, Il-Kun,Lee, Kyeong-Hun,Park, Chan-Woong The Korean Society of Pharmacology 1990 대한약리학잡지 Vol.26 No.2

국내 생산 enalapril maleate 10mg 제제 $(Beartec^{\circledR})$의 생물학적 동등성을 검토키위해, 원 제조원인 Merck사의 $Vasotec^{\circledR}$을 기준 제제로하여 12명의 건강한 남성지원자를 대상으로 10mg 1회 경구 투여 교차시험후 약동학적 성상, ACE활성억제의 경시적 변화 및 혈압 변동을 검토한 결과는 다음과 같다. 1. 혈장 enalapril 및 활성형 대사물인 enalaprilat의 생체이용율 지표들(AUC, Tmax 및 Cmax)의 평균치는 시험제제에서 enalapril의 최고 혈장농도 도달시간(Tmax)이 약 27%(0.21시간)지연되었을 뿐 타 지포는 대조제제에 대한 백분율 차이에 있어 ${\pm}20%$내외였다. 2. 혈장 enalapril및 enalaprilat의 생체 이용율 지표들은 분산 분석에 의해 두 제제간에 차이를 인지할 수 없었다. 3. 시험제제의 생체이용율 지표들은, 대조제제에 대한 백분율을 95% 신뢰구간 검정시, enalapril의 AUC 및 Tmax를 제외한 enalapril 및 enalaprilat의 모든 지표는 ${\pm}20%$ 내외의 결과를 보였다. 4. 두제제 투여후 ACE활성도는 enalaprilat 혈장농도 5-6ng/ml에서 50%의 억제를 보였으며, 투약 23시간까지의 활성억제 AUC는 차이가 없었다. 5. 두 제제 투여후 수축기 및 이완기 혈압은 투약 2시간 이후 유의한 감소를 보였으며 혈압 변동은 두제제간에 차이를 인지할 수 없었다. 이상의 실험 결과로 enalapril maleate의 국내 생산 generic product는 기준제제인 $Vasotec^{\circledR}$과 동등한 생물학적 동등성을 지니며 치료적 등가성을 보이는 제제로 판단하였다. Enalapril maleate tablets of two different producers were tested for bioequivalence. Enalapril is rapidly metabolized to an active metabolite, enalaprilat which inhibits angiotensin-converting enzyme (ACE). The pharmacokinetics of enalapril maleate and the time course of inhibition of plasma ACE activity after administration of the drugs were studied. Two single doses of 10mg each of enalapril maleate were administered orally to twelve male volunteers in a balanced, randomized, two-way crossover investigation. Plasma enalaprilat concentrations were determined over a 23-hour after the dose by enzyme inhibition assay and enalapril by the same method following in vitro hydrolysis. Urinary recoveries of enalapril and enalaprilat were determined for the calculation of renal clearance. Plasma ACE activity was determined by an enzyme assay. Peak plasma levels of enalapril were observed about 1 hour after the doses, and practically all enalapril had disappeared from plasma within 6 hour. Peak enalapril concentrations of both formulations were almost identical ($Vasotec^{\circledR}$, 61.38 ng/ml; $Beartec^{\circledR}$, 64.27 ng/ml). The values of the pharmacokinetic parameters of enalaprilat computed for $Vasotec^{\circledR}$ and $Beartec^{\circledR}$ tablets are presented in that order; area under the curve=330.63:320.96 $ng{\cdot}hr/ml$; peak concentration=38.63:39.43 ng/ml; time to peak=3.83:4.08 hour; elimination half-life=3.95:3.92 hours. No statistically significant difference was detected when area under the curve and all other parameters were compared. Using criteria of 95% confidence interval for the comparison of these parameters, only the upper limits of area under the curve and time to peak of enalapril were over 120%. All the parameters of enalaprilat were acceptable. Percent inhibition of plasma ACE to plasma enalaprilat concentration showed the sigmoid concentration-inhibition relationship. Time courses of plasma ACE inhibition after the administration of both formulations were quite similar. The formulations were found to be equivalent when compared on the premise that no significant difference was detected when pharmacokientic parameters and inhibition of ACE activity were compared, based on the confidence limits analysis.

여행사 종사원의 근로가치관이 조직몰입에 미치는 영향

최학수(Choi Hak-Soo),장병수(Jang Byung-Soo) 한국관광레저학회 2002 관광레저연구 Vol.13 No.2

Eye shadow 화장품에 첨가된 무기물질의 성분과 미세구조 분석

장아영 ( A Young Jang ),장병수 ( Byung Soo Chang ) 대한미용학회 2010 대한미용학회지 Vol.6 No.4

In this study, we investigated the microstructure and element of the ingredients of three kinds of eye shadow with different color each other commonly in use for eye make-up using scanning electron microscope and energy disperse X-ray spectroscope. In the examination of golden peach eye-shadow under observation of scanning electron microscope, mica covered by titanium dioxide was observed in a form of thin section. The mica with pearly luster was mostly observed. In the examination of brown eye-shadow, the particles of the mixture were relatively even in size and homogenous in composition. It was found that the inorganic matters of the mixture had talc, iron oxide black and iron oxide yellow as main component. Among them, talc was a major component of most matters. In the examination of deep brown eye shadow, the mixture was homogenous with small particles covering the surface of silica. The flakes of round silica and talc were observed, which were relatively big in size. The major component of it was iron oxide black with lumps in a form of thin flack around them. The inorganic elements comprising the golden peach eye-shadow were carbon, oxygen, magnesium, aluminum, silicon, potassium, titanium and iron. Silicon accounts for 13.32%, the largest portion, and iron 0.67%, the least portion. The brown eye-shadow were carbon, oxygen, magnesium, silicon and iron. Among them, silicon accounts for 17.31%, the largest portion, and iron 2.58%, the least portion. The deep brown eye shadow were carbon, oxygen, sodium, magnesium, aluminum, silicon, sulfur and iron. Among them, iron accounts for 45.37%, the largest portion, and aluminum 0.20%, the least portion. According to the results of elemental analysis of the inorganic matters comprising three types of eye shadow used in the present study, it was found that there are differences in the content of inorganic minerals which create a luster or chic effect depending upon the function of eye make-up.

Enalapril Maleate 정제의 동등성에 관한 연구 ; 약동학적 성상 및 혈장 ACE 활성도 억제 효과

장인진(In-Jin Jang),장병수(Byung-Soo Jang),신상구(Sang-Goo Shin),신재국(Jae-Gook Shin),노일근(Il-Kun Rho),이경훈(Kyeong Hun Lee),박찬웅(Chan Woong Park) 대한약리학회 1990 대한약리학잡지 Vol.26 No.2

국내 생산 enalapril maleate 10mg 제제 (Beartec^??)의 생물학적 동등성을 검토키위해, 원 제조원인 Merck사의 Vasotec^??을 기준 제제로하여 12명의 건강한 남성지원자를 대상으로 10mg 1회 경구 투여 교차시험후 약동학적 성상, ACE활성억제의 경시적 변화 및 혈압 변동을 검토한 결과는 다음과 같다. 1. 혈장 enalapril 및 활성형 대사물인 enalaprilat의 생체이용율 지표들(AUC, Tmax 및 Cmax)의 평균치는 시험제제에서 enalapril의 최고 혈장농도 도달시간(Tmax)이 약 27%(0.21시간)지연되었을 뿐 타 지포는 대조제제에 대한 백분율 차이에 있어 ± 20%내외였다. 2. 혈장 enalapril및 enalaprilat의 생체 이용율 지표들은 분산 분석에 의해 두 제제간에 차이를 인지할 수 없었다. 3. 시험제제의 생체이용율 지표들은, 대조제제에 대한 백분율을 95% 신뢰구간 검정시, enalapril의 AUC 및 Tmax를 제외한 enalapril 및 enalaprilat의 모든 지표는 ± 20% 내외의 결과를 보였다. 4. 두제제 투여후 ACE활성도는 enalaprilat 혈장농도 5-6ng/ml에서 50%의 억제를 보였으며, 투약 23시간까지의 활성억제 AUC는 차이가 없었다. 5. 두 제제 투여후 수축기 및 이완기 혈압은 투약 2시간 이후 유의한 감소를 보였으며 혈압 변동은 두제제간에 차이를 인지할 수 없었다. 이상의 실험 결과로 enalapril maleate의 국내 생산 generic product는 기준제제인 Vasotec^??과 동등한 생물학적 동등성을 지니며 치료적 등가성을 보이는 제제로 판단하였다. Enalapril maleate tablets of two different producers were tested for bioequivalence. Enalapril is rapidly metabolized to an active metabolite, enalaprilat which inhibits angiotensin-converting enzyme (ACE). The pharmacokinetics of enalapril maleate and the time course of inhibition of plasma ACE activity after administration of the drugs were studied. Two single doses of 10mg each of enalapril maleate were administered orally to twelve male volunteers in a balanced, randomized, two-way crossover investigation. Plasma enalaprilat concentrations were determined over a 23-hour after the dose by enzyme inhibition assay and enalapril by the same method following in vitro hydrolysis. Urinary recoveries of enalapril and enalaprilat were determined for the calculation of renal clearance. Plasma ACE activity was determined by an enzyme assay. Peak plasma levels of enalapril were observed about 1 hour after the doses, and practically all enalapril had disappeared from plasma within 6 hour. Peak enalapril concentrations of both formulations were almost identical (Vasotec^??, 61.38 ng/ml; Beartec^??, 64.27 ng/ml). The values of the pharmacokinetic parameters of enalaprilat computed for Vasotec^?? and Beartec^?? tablets are presented in that order; area under the curve=330.63:320.96 ng⋅hr/ml; peak concentration=38.63:39.43 ng/ml; time to peak=3.83:4.08 hour; elimination half-life=3.95:3.92 hours. No statistically significant difference was detected when area under the curve and all other parameters were compared. Using criteria of 95% confidence interval for the comparison of these parameters, only the upper limits of area under the curve and time to peak of enalapril were over 120%. All the parameters of enalaprilat were acceptable. Percent inhibition of plasma ACE to plasma enalaprilat concentration showed the sigmoid concentration-inhibition relationship. Time courses of plasma ACE inhibition after the administration of both formulations were quite similar. The formulations were found to be equivalent when compared on the premise that no significant difference was detected when pharmacokientic parameters and inhibition of ACE activity were compared, based on the confidence limits analysis. plasma ACE inhibition after the administration of both formulations were quite similar. The formulations were found to be equivalent when compared on the premise that no significant difference was detected when pharmacokientic parameters and inhibition of ACE activity were compared, based on the confidence limits analysis. plasma ACE inhibition after the administration of both formulations were quite similar. The formulations were found to be equivalent when compared on the premise that no significant difference was detected when pharmacokientic parameters and inhibition of ACE activity were compared, based on the confidence limits analysis.

벽체의 강성을 고려한 철근콘크리트 뼈대 구조물의 비탄성 손상 해석

최진혁(Choi Jin Hyuk),박순응(Park Soon eung),박문호(Park Moon Ho),장병수(Jang Byung Soo),이봉동(Lee Bong Dong) 대한토목학회 2010 대한토목학회 학술대회 Vol.2010 No.10

전통문화축제에 대한 관광객의 참여 지각이 사후태도에 미치는 영향

장병수,박재길 문화관광연구학회 2002 문화관광연구 Vol.4 No.4

This study focuses on positively identifying the correlation between the recognition process affecting tourists' attitude and their post attitude in terms of traditional culture festival, thus to forecast their attitude. In this viewpoint, the study models were designed and the corresponding hypotheses were established in detail based on such models. Statistical processing of collected data was analyzed with SPSS/WIN statistical package. Finally, as a result of analyzing tourists' recognition, it was shown that there was higher score in participation rate, recognition and satisfaction in terms of Cheongdo Bull Fighting Festival, which was already established as a regional traditional culture festival. In particular, this festival reflected local feature and differential characters so well and was recognized as a festival with the international potential.

여행사의 항공사 선택요인에 미치는 항공마케팅 전략에 관한 연구

김재원,장병수 문화관광연구학회 2001 문화관광연구 Vol.3 No.3