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김배영(Bai Young Kim),김효종(Hyo Jong Kim),정형근(Hyung Keun Chung),김영관(Young Kwan Kim),동석호(Seok Ho Dong),김병호(Byung Ho Kim),이정일(Jung Il Lee),장영운(Young Woon Chang),장린(Rin Chang) 대한내과학회 1993 대한내과학회지 Vol.45 No.5
N/A Background: According to the rapid changes in social environment such as increasing alcohol consumption and the marked improvement in diagnostic technique, we expect that there have been major changes in various aspects of acute pancreatitis during the recent 12 years in Korea. Methods: The medical records of 317 patients with acute pancreatitis diagnosed from 1980 through 1992 were reviewed about clinical, laboratory and radiological findings in the three different time period. Results: 1) There has been an increasing incidence in male sex about three folds. 2) There has been an increasing trends in the duration of hospitalization. 3) A significant increase was observed in the proportion of patients with alcoholic pancreatitis in the three different time period; 26.9%, 45.7%, 50.7% respectively. 4) The complication rates have been slightly increased in the three different time period; 46.3%, 47.1%, 59.1% respectively. But, the type of complications has not been changed. 5) There is increasing severity in non-gallstone group, but no significant differences in gallstone group. There is a declining trends in the number of patients with muld severity index, but increasing trend in the number of patients with moderate severity index in non-gallstone group. 6) There was no significant differences in mortality rate. Conclusions: There has been major changes in the etiology ans severity of acute pancreatitis from 1980 through 1992. Especially, significant increase in the proportion of patients with alcoholic pancreatitis was observed in the three differnt time period. These results might be due to socioeconomic changes.
속박 (束縛) 과 침수 (浸水) 로 유도된 흰쥐의 스트레스성 급성 (急性) 위점막병변 (胃粘膜病變) 발생에 있어서 위산분비의 (胃酸分泌) 역할
민영일(Young Il Min),박충기(Choong Kee Park),장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),박승준(Seung Joon Park),정주호(Joo Ho chung),정지창(Jee Chang Jung) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1
N/A The possible roles of gastric acid secretion in the pathogenesis of stress ulcers induced by restraint with water-immersion for 7 hours in pylorus-ligated rats were investigated. Control rats with pylorus-ligation only did not show any gastric mucosa} lesion, and their mean gastric acid output was 449.2 ± 36.1 umol/rat. In contrast, the stressed rats, group II, showed multiple, punctate and hemorrhagic erosions in gastric mucosa, and mean gastric acid output was decreased to the level of 253.7 ± 27.3 umol/rat. Subcutaneous administration of histamine(40 mg/kg every 2.5 h for a total three times) to stressed rats augmented the lesion with severe multiple, linear and hemorrhagic erosions and mean acid output increased significantly (328.1 ± 31.5 umol/, p<0.005) compared with group II. Pretreatment with rantidine(20 mg/kg) or prostaglandin E2 (30 ug/kg) before exposure to stress reduced gastric lesion formation slightly with no significance. In ranitidine pretreated rats, mean gastric acid output was decreased significantly (120.1 ± 15.3 umol/rat, p<0.005) compared with group II. However, in prostaglandin pretreated rats, mean gastric acid output showed no significant changes. Therefore, it is suggested that increased gastric acid secretion seems to be an aggravating or a permissive factor rather than a major factor in the pathogenesis of stress-induced gastric mucosal lesions.
SV40 T 항원의 온도조건부 변이형 유전자가 포함된 Amphotropic Retrovirus 에 의한 사람 태아 간세포의 불멸화
이정일(Joung Il Lee),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),김병호(Byung Ho Kim),장영운(Young Woon Chang),장린(Rin Chang),성세라(Se Ra Seong),박재경(Jae Kyung Park),김승보(Seung Bo Kim),이상목(Sang Mok Lee) 대한내과학회 1999 대한내과학회지 Vol.57 No.1
N/A Human cells are almost never spontaneously immortalized in vitro. We tried to immortalize human fetal hepatocytes (h-FH) and evaluate the differentiational status and its change. Methods : Hepatocytes were isolated from a liver fragment of 20 week old fetus and infected with amphotropic recombinant retrovirus containing a temperature- sensitive mutant of SV40 large T antigen and neomycin phosphotransferase gene. G418 resistant colonies were cloned and expanded. The cells which were able to divide more than 30 times were used to analyze various functions. Results : The immortalization rate was 3.3 x 10-8 and two cell lines (C11, D21) were established. C11-60, C11-80, D21-30 and D21-60 (suffix number means the cell division counts) were evaluated. D21-30 was thougt to be imcompletely immortalized because a considerable portion of cells died during culture. The morphology was similar to that of epithelial cells except for D21-30 which looked like fibroblast. The cells grew rapidly at 33oC but stopped growing at 39oC. T antigen and p53 was expressed at 33oC but disappeared at 39oC, which suggest that T antigen binds to p53. Chromosomal changes were so marked that it was impossible to discriminate exact number. Albumin was secreted as about 1/10 as that of h-FH, but alpha-fetoprotein secretion stopped after immortalization. Telomerase was activated in both cell lines except for the incompletely immortalized cells D21-30. Telomere was elongated in competely immortalized cell lines, but it was rather shortened in D21-30 compared to that of h-FH. Macroscopic colonies did not develop in soft agar assay. Conclusions : We successfully immortalized human fetal hepatocytes. Although the cells are not likely to have oncogenicity, the functions are not so good, possibly due to marked chromosomal changes which are thought to occur before telomerase is activated during immortalization step.
위궤양환자에서 Rebamipide ( MUCOSTAR ) 의 치료 효과
장린(Rin Chang),김효종(Hyo Jong Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A Baekground: H2, blockers have been the first drug of choice in the non-surgical cares of peptic ulcer patients, but have raised the clinical problem of recurrence promptly following discontinuation of use . One of the arguments concerning recurrence refers to the drastic suppression of aggressive factors, probably deteriorating the defence factors. Extensive research have been conducted to accumulate the knowledge on the defense mechanism of the gastric. mucosa in order to advocate the use of H - blockers in the treatment of gastric uIcer. Rebamipide is a novel antiulcer agent that enhances the mucosal defensive mechanism by increasing the generation of endogenous prostaglandins which controls the overall defensive mechanism. Methods: To evaluate the effect of Rebamipide on the gastric ulcer disease, Rebamipide(MUCOSTA ) was orally daministered 100 mg three times a day for 8 weeks to 30 patients with benign active gastric ulcer disease. Results: Subjective symptorns were remarkably improved in 66.7% of the subjects. Active stage of gastric ulcer were remarkably improved in 70% of the subjects. General improvement rate was remarkable 70.0% and effectiveness rate of Rebamipide was 83.3% after 8 weeks of treatment. No significant clinical side effects had been noticed. Conclusion: These results indicate that oral administration of Rebamipide is effective and safe treatment of gastric ulcer disease. But for the higher healing rate, more long term treatment of Rebamipide should be considered.
심한 이장열과 백혈구증가증을 동반한 원발성 간세포암 2예
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Joung Il Lee),김효종(Hyo Jong Kim),동석호(Seok Ho Dong),최태열(Tae Yeoul Choi),김재필(Jae Pil Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Fever occurs frequently in cancer patients and is caused by tumor itself as well as infection and primary hepatocellular carcinoma is known to be no exception. Although hepatoma may usually be differentiated from liver abscess, the clinical presentations of liver abscess and hepatoma may sometimes be quite so similar that many diagnostic methods cannot make a specific diagnosis. It is important to make differential diagnosis between these two disease because early estahlishment of correct cause and appropriate treatment can save the patients from the risk of mortality. We report two cases of primary hepatocellular carcinoma presenting with high fever & leukocytosis clinically mimicking liver abscess and review mainly about the differential diagnostic methods and their importance.
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),김효종(Hyo Jong Kim),동석호(Seok Ho Dong),박현주(Hyun Ju Park),김경진(Kyeong Jin Kim),정일우(Il Woo Jung) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5
Subcostosternal diaphragmatic hernia of Morgagni is the least common type of congenital diaphragmatic hernia. It is usually seen at two stages in life-infancy and adulthood. In adulthood, the majority of cases are asymptomatic or produce minimal symptoms. A 73-year-old women who had a 2 1/2-year history of right upper quadrant(RUQ) abdominal pain was admitted to our hospital. She was diagnosed as acute cholecystitis due to RUQ abdominal pain, and then underwent a cholecystectomy at a provincial general hospital 1 1/2 year ago. Although her symptom slightly improved for a while after the operation, she began feeling the RUQ abdominal pain again. Examination by chest X-ray, barium enema, and chest CT, it was revealed as Morgagnis hernia contained within the omentum and transverse colon. With a transthoracic approach we could reduce the hernia and repair the diaphragmatic defect. (Korean J Gastroenterol 1997; 30:684-688)
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),황이숙(Yi Sook Hwang),김효종(Hyo Jong Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
Membranous Obstruction of the Inferior Vena Cava (MOVC) is a raredevelopmental abnormality of the inferior vena cava at the level of diaphragm. Because MOVC secondarily impedes hepatic venous drainage, it causes severe chronic venous congestion and centrolobular fibrosis of liver. MOVC has recently been documented as a risk factor for hepatocellular carcinoma in South African Blacks and Japanese. We report here our experience with a case of MOVC with hepatocellular carcinoma to give special emphasis to the differences in presentation and treatment with classic Budd-Chiari syndrome and the imperative necessity of the surgical correction of the defect with early detection.
간장 및 담도 : 간경변증 환자의 난치성 복수의 치료에 있어서 체외 복강정맥 단락 ( External peritoneovenous shunt ) 의 사용 경험
장린 ( Rin Chang ),박충기 ( Choong Kee Park ),민영일 ( Young Il Min ),장영운 ( Young Woon Chang ),주영실 ( Yeong Shil Ju ),방익수 ( Ik Soo Bang ),조정휘 ( Jeong Whee cho ) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A In order to evaluate the effectiveness of the external peritoneovenous shunt in controlling the ascites, we have performed the procedure in three patients with intractable ascites. The bedside external peritoneovenous shunt had several advantages over the LeVeen shunt. The summary of the results were as follows; 1) A surgeon and operating room are not required. 2) Peritoneal dialysis catheter can be easily inserted and removed. 3) The abdominal binder is not required. 4) The infusion of the ascitic fluid is under precise control. 5) Definitive short-term therapy. Conclusively, the external peritoneovenous shunt is a very easy procedure to perform and its trial is of value in the medical treatment of intractable ascites.
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Joung Il Lee),김효종(Hyo Jong Kim),김영관(Young Kwan Kim),동석호(Seok Ho Dong),이원호(Won Ho Lee),김석호(Seok Ho Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1
Inflammatory pseudotumor of the liver is rare acute benign lesion that is frequently misdiagnosed to be malignant tumor such as hepatocellular carcinoma or choiangiocellular carcinoma by imaging & gross morphologic characteristics during the hepatic resection. Its pathogenesis and etiology has not been elucidated exactly yet. We report a case of hepatic pseudotumor in 50 year old male who suffered from intrahepatic stones. E. coli was cultured from the pus of the abscess pocket complicated by stones within the pseudotumor. So the possibility of infection might be advocated once again as its cause.