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Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
임정수,홍남기,박성하,박성일,오영택,유민희,임필용,이유미 대한내분비학회 2018 Endocrinology and metabolism Vol.33 No.4
Background: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravatecardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism(PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined howchanges in calcium and PTH levels influence cardiovascular outcomes in PA patients. Therefore, we investigated the impact of altered calcium homeostasis caused by excessive aldosterone on cardiovascular parameters in patients with PA. Methods: Forty-two patients (mean age 48.8±10.9 years; 1:1, male:female) whose plasma aldosterone concentration/plasma reninactivity ratio was more than 30 were selected among those who had visited Severance Hospital from 2010 to 2014. All patients underwent adrenal venous sampling with complete access to both adrenal veins. Results: The prevalence of unilateral adrenal adenoma (54.8%) was similar to that of bilateral adrenal hyperplasia. Mean serumcorrected calcium level was 8.9±0.3 mg/dL (range, 8.3 to 9.9). The corrected calcium level had a negative linear correlation withleft ventricular end-diastolic diameter (LVEDD, ρ=–0.424, P=0.031). Moreover, multivariable regression analysis showed that thecorrected calcium level was marginally associated with the LVEDD and corrected QT (QTc) interval (β=–0.366, P=0.068 andβ=–0.252, P=0.070, respectively). Conclusion: Aldosterone-mediated hypercalciuria and subsequent hypocalcemia may be partly involved in the development of cardiac remodeling as well as a prolonged QTc interval, in subjects with PA, thereby triggering deleterious effects on target organs additively.