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성현주(Hyun Ju Sung),임인기(In Ki Rim),천진옥(Jin Ok Chun),임성희(Sung Hee Ihm),최문기(Moon Ki Choi),유형준(Hyung Joon Yoo),박성우(Sung Woo Park),장연복(Young Bok Chang),강성원(Sung Won Kang) 대한내과학회 1994 대한내과학회지 Vol.47 No.3
N/A Postpartum thyroid dysfunction is a syndrome of thyroid dysfunction that occurs in the first year after delivery. Presenting clinically as either painless hypothyroidism or thyrotoxicosis, it usually resolves spontaneously. At the time postpartum thyroid dysfunction occurs, the relationship between thyroid antibodies and postpartum thyroid dysfunction is even stronger. The close association of these antibodies with postpartum thyroid dysfunction makes the detection of these antibodies an attractive method for screening large number of pregnant or postpartum women at risk for this disease. Of the 250 women screened on the second postpartum day, 22 women (8.8%) had positive results for serum antimicrosomal antibody. Among the normal controls, 16% had positive results. 18 of these 22 seropositive patients were followed for at least 6 months postpartum. 6 patients (2.4%) developed goiter, and 5 patients (2.0%) had biochemical thyroid dysfunction. All 5 patients developed hypothyroidism without thyrotoxic phase. The disease was mild and transient in two patients. But in remaining 3 patients, goiters and symptoms of hypothyroidism persisted and were treated. The titers of antimicrosomal antibody in women who developed the disease, increased progressively in all patients. Therefore, serum antimicrosomal antibody test after delivery will be useful as a screening test to detect thyroid dysfunction.