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임승택,전예원,서영진 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4
Purpose The current TNM staging system for papillary thyroid cancer (PTC), which is based on tumor diameter, may not precisely reflect the true tumor burden. Therefore, we investigated whether preoperative tumor volume might more accurately reflect tumor burden and predict prognosis in patients with T1N0 PTC than preoperative tumor diameter. Materials and Methods We retrospectively reviewed data from 1,659 patients with T1N0 PTC, and after exclusion, a total of 1,081 patients were ultimately included. Tumor volume (V) was calculated for all patients using preoperative ultrasonography, and patients were grouped according to tumor diameter (T1a vs. T1b) and tumor volume (V1a vs. V1b). The recurrence-free survival (RFS) rates were then compared for these groups. Results The mean follow-up time was 66.12±28.75 months, and 97.2% of the cohort experienced RFS. The optimal volume cut-off was defined as 0.545 cm3. There were no differences in RFS rates between T1a/T1b groups (all ages) and V1a/V1b groups (< 45 years of age). However, 45-year-old patients in the V1b group had a significantly poorer RFS rate than those in the V1a group. These results were confirmed by multivariate analysis. Conclusion Our results indicate that preoperative tumor volume may be more useful for predicting prognosis than tumor diameter in 45-year-old patients with T1N0 PTC.
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임승택 경상대학교 농업생명과학연구원 2011 농업생명과학연구 Vol.45 No.6
본 연구는 20세기 초기의 서양 흔들의자를 분석하여 조형적, 실용적 관점에서 양식적 특징을 학문적으로 규명하고, 오늘날 우리나라 흔들의자의 설계 및 제작의 기초자료를 제공하는 것에 목적이 있다. 20세기 전반의 서양 흔들의자(1925~1945년 제작)는 형태가 기능을 따라야 한다는 단순한 기능주의의 이념을 적극적으로 표현하였다. 원목을 활용한 흔들의자는 표면장식을 배제하였고, 강철관 프레임의 흔들의자는 검정색 가죽의 업홀스터리를 즐겨 사용하면서 노출된 구조미를 대담하게 표현하였다. 또 강철관을 통하여 가구의 경량화가 이루어졌고 곡선미 있는 새로운 양식이 출현하였다. 근대 흔들의자의 구조는 양식과 기능적 이유에서 모두 중요하게 되었다. 디자이너들은 강철관과 목재 프레임의 노출된 구조를 통합성 및 합리성과 결부 시켜 디자인의 평등주의 스타일을 만들어냈다. 특히 이 시기에는 밝고 대담한 색상의 업홀스터리와 목재 프레임으로 구성된 흔들의자가 근대적 특징의 단순한 형태로 다양하게 표현되었다. This research is intended to study literatures relating to western rocking chairs style in early 20th century in order to provide basic data of designs for rockers of today in Korea and investigate characteristics of rocking chair from academic, formative and pragmatic perspectives. During the first half of 20th century, western rocking chairs (1925~1945) embodied actively the simple functionalism concept that furniture design must follow functionality considerations. Therefore, bare wood rocking chairs were without any surface decoration and tubular steel frame rocking chairs often included black leather upholstery in a bold attempt to express exposed structure. And the fact that tubular steel produced such lightweight furniture was crucial importance. Many Modernist designer created curvaceous lines of new pattern changes in their furniture. The structure of Modern rocking chair became all-important, for stylistic as well as functional reasons. Designers equated exposed structure of tubular steel and wooden frame with integrity and rationality and create an equalitarian style of design. Especially, designers in the early 20th century did use various brilliantly colored upholstery and wooden frame with simple forms of modern characteristics.
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임승택,임선민,김민주,박신영,김주항 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.10
Purpose: Sonic hedgehog (Shh) signaling pathway is known to play a crucial role in carcinogenesis in various malignancies, includinglung cancer regarding tumorigenesis, angiogenesis, and cellular differentiation. The aim of this study was to investigatethe value of components of Shh pathway as a prognostic marker in extensive stage small cell lung cancer (ES-SCLC) patients. Materials and Methods: We retrospectively analyzed data of 36 patients who were diagnosed with ES-SCLC between 2008 and2012 at a single center. We performed immuo-histochemistry for glioma-associated oncogene homolog zinc finger protein 1 (Gli1),patched, Shh, and Ptch-mediated repression of smoothened (Smo) proteins using formalin-fixed, paraffin-embedded tissue derivedfrom primary tumors. We then conducted survival analysis to evaluate the prognostic impact of these markers. Results: All 36 patients received platinum-based doublet chemotherapy. The median progression free survival and median overallsurvival were 6.9 months [95% confidence interval (CI), 6.5–7.3] and 11.7 months (95% CI, 9.1–14.3), respectively. The overall responserate was 84%. Of the 36 tissue specimens examined, over-expression of Gli1, Patched, Shh, and Smo was found in 12(33.3%), five (13.9%), five (13.9%), and six (16.7%) cases, respectively. We found that high expression of Shh was associated withworse progression free survival (6.3 vs. 7.6 months, p=0.005) and overall survival (9.2 vs. 12.0 months, p=0.039) by both univariateand multivariate analyses, whereas other markers were not related to patient prognosis. Conclusion: A high proportion of small cell lung cancer tumors express proteins related to Shh pathway, and over-expression ofShh is correlated with poor prognosis.
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제2부 웰빙과 불교수행 : 불교적 웰빙(well-being) 담론의 가능성
임승택 사단법인 한국교수불자연합회 2007 한국교수불자연합학회지 Vol.13 No.-
``잘 사는 문제`` 즉 웰빙에 대한 논의는 동서고금을 통하여 진행되어 왔으나, 또한 인류가 존속하는 한 계속될 것이다. 필자는 이러한 웰빙 담론이 각각의 시대에 처한 삶의 양식에 대한 총체적인 반성과 함께 진행되어야 하며, 이상적인 삶의 모색이라는 방향성을 놓치지 말아야 한다고 생각한다. 그러고 이러한 맥락에서 웰빙에 대한 불교적 접근에 나름의 의미를 부여하며, 바로 이점을 조명하기 위해 본고를 기술하였다. 필자는 불교적 웰빙 담론이 세속적인 행복과 출세간적인 행복을 망라하는 것임을 역설하였다. 나아가 이것이 내면의 행복을 위한 것일 뿐만이 아니라, 사회적 실천 원리로서의 성격을 지닌다는 점에 대해서도 언급하였다. 불교적 관점에서 볼 때, 이상적인 삶은 개인적인 완성과 사회적 실천이 조화를 이루는 것이어야 한다. 이러한 내용은 현재의 웰빙 담론이 어떠한 방식으로 진행되어야 하는가를 되짚어 보게 하는 계기가 될 수 있을 것이다. Well-Being has great interest for many people nowadays. In fact, the subject of Well-Being has been carried on discussion through the human history. This discussion may be continued so far as human beings exist. The subject of Well-Being is related to how we live our own life to be good. In connection with this, I have tried to find out the possibility of better life Buddhistic discourse on Well-Being. In this paper, I asserted that Buddhism pursues both the mundane happiness and unworldliness. Going one step forward, I made it clear that Buddhism teaches us not only the inside happiness but also the social principles of the practice. In this point, I tried to get rid of some misunderstanding, that is, Buddhism is exclusively interested in the inside happiness. We can say that the perfection of the self should be corresponded with the social practice. I made an attempt to seek out the models of good life from Buddhistic point of view. And I showed some instances of models from Nik?ya which is an early Buddhistic canon. I think this work will endow us with the opportunity to reflect on the present discourse of Well-Being and find out the ideal models of Well-Being.
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