http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
임상재,류왕성,유언호 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
The catecholamines are key regulators of many physiologic events in human beings. These catecholamine initiate target-cell response by binding to specific recognition sites, the adrenergic receptors. Super-and subsensitivity of the myocardial receptors and their functional status during myocardial failure have important clinical and pharmacological implications. The development of radioligand binding technique using radioactively labeled hormones or drugs, either agonists or antagonists, opened the new era of receptor investagarion. 〔^3H〕 Dihydroalprenolol was used to identify the veta-adrenergic receptors of rat cardiac membranes in this study. The concentration dependence of 〔^3H〕Dihydroalprenolol binding was studied with labeled compounds of various concentrations ranging from 5x 10^-11 M to 1.5x_-8M. Specific 〔^3H〕Dihydroalprenolol binding was a saturable process and Scatchard analysis of the data showed a single class of binding sites characterized by an equilibrium dissociation constant Kd of 5.2x 10^-9M and a calculated Bmax of about 68.8 fmol/mg protein. The specific binding occurred as rapidly and reversibly as the response to the unlabeled ligand and it increased as a linear function of increasing tissue concentration. Levo epinephrine was more potent than levo norepinephrine in inhibiting 〔^3H〕Dihydroalprenolol binding. The use of 〔^3H〕Dihydroalprenolol to identify beta-adrenergic receptors will make possible the study of alterations in number and affinity of cardiac beta-receptors in many clinical states of altered sensitivity to catecholamines.