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임남희,유성태,장미혜,박성진,한병성 전북대학교 전자산업개발연구소 1990 전자산업연구 Vol.1 No.-
The relations of the sintering temperature and superconductivity were investigated by the XRD pattern and critical temperature. All of the samples were annealed at the various temperatures that from 900℃ to 960℃. When the superconductor of YBa_2Cu_3O_7-8 was exposed in the air and was directly contacted with water. The samples of the surface attack by moisture and water was studied. The samples were analyed XRD, TGA. The samples of YBa_2Cu_3O7-8 which were exposed to the air for a long time have slowly decomp-sed, but the samples of YBa_2Cu_3O7-8 which were directly contacted with the D.I. water have rapidly decomposed on surface. The YBa_2Cu_3O_7-8 superconductor is chemically instable; by the reaction with humidity. The YBa_2Cu_3O_7-8 is transformed into non-superconduction phase(Y_2BaCuO_5, Ba(OH)_2, CuO) and loses is superconducting properties.
임남희,마진열 한약정보연구회 2020 한약정보연구회지 Vol.8 No.2
Dalbergiae Odoriferae Lignum has long been used to treat for dissipating blood stasis, regulating blood flow, and relieving pain as traditional herbal medicine. In this study, the extracts of Dalbergiae Odoriferae Lignum and nerolidol, a major volatile oil of Dalbergia odorifera, were evaluated for antibacterial activity against four common oral bacteria. Hot-water extract of Dalbergiae Odoriferae Lignum (DOW), 70% ethanol extract of Dalbergiae Odoriferae Lignum (DOE), and nerolidol were tested for the growth inhibition against Enterococcus faecalis, Actinomyces viscosus, Streptococcus mutans, and Streptococcus sanguis by broth microdilution assay in brain heart infusion (BHI)-broth and by dot-blot assay in BHI-agar, used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), respectively. The activity of Glucosyltransferase (GTase) from S. mutans was determined with glucan formation. To confirm the safety of Dalbergiae Odoriferae Lignum, DOW was tested the acute toxicity by administering orally to ICR mice. In the present study, DOW, DOE, and nerolidol showed significant antibacterial activities at high concentrations against the four types of pathogenic oral bacteria, especially showed strong antibacterial activities at S. mutans in a dose-dependent manner. Additionally, DOW and DOE decreased the synthesis of water-insoluble glucans by inhibiting the GTase activity, while nerolidol did not work. Further, DOW determined the LD50 values over 5,000 mg/kg in mice and proved DOW’s safety. These results suggest that Dalbergiae Odoriferae Lignum, including DOW and DOE, and nerolidol proven antibacterial activities may be useful for treating dental diseases.
임남희,구민정,황윤환,조원경,마진열 한국한의학연구원 2016 Integrative Medicine Research Vol.5 No.4
Background Galla Rhois has been considered to have medicinal properties against diarrhea, excessive sweating, bleeding, and chronic cough in Asian countries. Gallotannins, which are Galla Rhois-derived tannins, have been reported to possess biological and pharmacological activities, especially anticancer activity. In this study, we evaluated the effect of steaming at a temperature over 120 °C on the chemical constituents and biological activities of the water extract of Galla Rhois (GRE). Methods GRE was steamed at a temperature over 120 °C (AGRE), and its specific constituents were analyzed; the results were validated using a high-performance liquid chromatography–diode array detector system. To evaluate the anticancer effect of GRE and AGRE, cell viability assay, cell cycle analysis, and Western blot analysis were performed in HCT116 human colon cancer cells. Results Steaming markedly increased the contents of gallic acid and ellagic acid in GRE, and GRE or AGRE treatment reduced the viability of HCT116 cells. Notably, the steaming process enhanced the growth inhibitory effect of GRE in cancer cells. AGRE induced apoptosis through the activation of caspase-3, caspase-8, and caspase-9. Additionally, AGRE regulated the activation of mitogen-activated protein kinases including extracellular signal-regulated kinase, p38, and c-Jun NH2-terminal kinase, whereas GRE did not. However, both GRE and AGRE inhibited the activation of AKT. Conclusion Compared with GRE, AGRE is more potent in its ability to induce apoptosis in HCT116 cells; therefore, we suggest that the steaming process may be useful as a feasible method for improving the anticancer effect of GRE.
Screening of aqueous extracts of medicinal herbs for antimicrobial activity against oral bacteria
임남희,정영필,조원경,김태수,김애영,임민주,마진열 한국한의학연구원 2013 Integrative Medicine Research Vol.2 No.1
Background: Dental caries is considered to be a preventable disease, and various antimicrobial agents have been developed for the prevention of dental diseases; however, many bacteria show resistance to existing agents. In this study, 14 medicinal herbs were evaluated for antimicrobial activity against five common oral bacteria as a screen for potential candidates for the development of natural antibiotics. Methods: Aqueous extracts of medicinal herbs were tested for activity against Enterococcus faecalis, Actinomyces viscosus, Streptococcus salivarius, Streptococcus mutans, and Streptococcus sanguis grown in brain heart infusion (BHI) broth. A broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). A disk diffusion assay was performed by inoculating bacterial cultures on BHI agar plates with paper disks soaked in each of the medicinal herb extracts. Inhibition of the synthesis of water-insoluble glucans by S. mutans was also investigated. Results: The aqueous extracts of many of the 14 medicinal herbs demonstrated antimicrobial activity against the five types of pathogenic oral bacteria. The extracts of Sappan Lignum, Coptidis Rhizoma, and Psoraleae Semen effectively inhibited the growth of oral bacteria and showed distinct bactericidal activity. The extracts of Notoginseng Radix, Perillae Herba, and Psoraleae Semen decreased the synthesis of water-insoluble glucans by the S. mutans enzyme glucosyltransferase (GTase). The present study is the first to confirm the antimicrobial activity of the extract of Sappan Lignum against all five species of oral bacteria strains. Conclusion: These results suggest that certain herbal medicines with proven antimicrobial effects, such as Sappan Lignum and Psoraleae Semen, may be useful for the treatment of dental diseases.