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도토리에서 분리한 Dotorioside I, II의 구조
임광식,손미정,이시강,Im, Kwang-Sik,Son, Mee-Jeong,Lee, See-Kang 대한약학회 1994 약학회지 Vol.38 No.3
From the methanolic extractive of the fruits of Quercus acutissima $C_{ARRUTHERS}$(Fagaceae) a mixture(QC-A saponin) of two ester glycosides, which were named as dotorioside I(3) and ll(4), was separated by silica gel column chromatography and HPLC. The structures of these two glycosides including their genuine aglycones(1,2) were elucidated as 1: $2{\alpha}$, $3{\beta}$, $19{\alpha}$, 23-tetrahydroxyolean-12-en-28-oic acid, 2: $2{\alpha}$, $3{\beta}$, $19{\alpha}$, 23-tetrahydroxyurs-12-en-28-oci acid, 3: 28-O-${\beta}$-D-glucopyranosyl ester of 1, 4: 28-O-${\beta}$-D-glucopyranosyl ester of 2, respectively, on the basis of chemical and spectral evidence.
국내산 해면 Spirastrella abata로부터 Sterol Peroxide 유도체의 분리
임광식,남경인,심정자,정지형,Im, Kwang-Sik,Nam, Kyung-In,Sim, Chung-J.,Jung, Jee-H. 한국생약학회 2000 생약학회지 Vol.31 No.4
Marine sponges are known to be a source of diverse sterols. In our study on the cytotoxic components of the marine sponge Spirastrella abata, $5{\alpha},8{\alpha}-epidioxy\;{\Delta}^6$ sterols (1-5) and $5{\alpha},8{\alpha}-epidioxy\;{\Delta}^{6,9(11)}$ sterols (6-7) were isolated. The structures were identified based on the analyses of $^1H-NMR,\;^{13)C-NMR$, and MS data. These compounds were assayed for cytotoxicity against 5 human solid tumor cell lines including A549, SK-OV- 3, SK-MEL-2, XF498, and HCT15.
홍조 꼬시래기(Gracilaria verrucosa) 유래의 글리세로당 Floridoside의 화학구조
노연숙,손병화,임광식,최홍대,Roh, Yeon-Suk,Son, Byeng-Wha,Im, Kwang-Sik,Choi, Hong-Dae 한국생약학회 1994 생약학회지 Vol.25 No.2
As part of search for new biologically active substances from marine organism, we have isolated a glyecrol glycoside from the marine red alga Gracilaria verrucosa. The structure of the glycerol glycoside was elucidated as 2-O-${\alpha}-_D$-galactopyranosylglycerol[floridoside(4)] on the basis of spectroscopic and physicochemical evidences.
서춘석 ( Seo Chun Suk ),임상준 ( Im Sang Jun ),박승우 ( Park Seung Woo ),윤광식 ( Yoon Kwang Sik ) 한국농공학회 2000 한국농공학회 학술대회초록집 Vol.2000 No.-
CREAMS-PADDY model for simulating daily water and nutrient balance at irrigated paddies was developed, applied to, and validated with field data. The model simulates daily flooding depth and total nitrogen and phosphorus concentrations from meterorological, irrigation, and farming data. Simulated results from the model were in good agreement with field data. Among different scenarios to reduce nutrient losses from paddies, the water management was found to be very effective, and recommended for field applications.
양한숙(Han-Suk Young),임광식(Kwang-Sik Im),최재수(Jae-Sue Choi) 한국식품영양과학회 1992 한국식품영양과학회지 Vol.21 No.3
고들빼기 잎으로부터 플라보노이드인 luteolin, luteolin 7-0-glucoside 및 apigenin 7-0-glucuronide를 분리하고 그들의 구조를 기기적인 분석방법에 의하여 동정하였으며 또한, 유리 아미노산과 관련 화합물들의 조성과 상대함량을 표준품과 동일조건하에서 아미노산 자동분석기로 비교 검토하였다. 가장 함량이 많은 유리 아미노산들은 glutamic acid, aspartic acid, serine, proline, valine 그리고 arginine이었다. From the leaves of Ixeris sonchifolia (Compositae), luteolin and its glucoside and apigenin glucuronide were isolated and their structures were characterized on the basis of spectral data. Besides these flavonoids, the composition and relative content of free amino acids and related compounds, compared to standards determined under identical conditions was also investigated using automatic amino acid analyzer. Major free amino acids were glutamic acid, aspartic acid, serine, proline, valine and arginine.
김정선,남규,심경희,김규원,임광식,정해영,Kim, Jung-Sun,Nam, Kyu,Shim, Kyung-Hee,Kim, Kyu-Won,Im, Kwang-Sik,Chung, Hae-Young 한국생명과학회 1996 생명과학회지 Vol.6 No.1
Oxygen free radicals are highly reactive molecules with unpaired electrons, which are produced with in aerobic cells in the course of normal metabolic events. Normally, aerobic cells are protected from the damage of free radicals by antioxidative enzymes such as superoxide dismutase (SOD), catalase, glutathione (GSH) peroxidase, GSH S-transferase and GSH reductase which scabvenge free radicals as well as nonenzymatic antioxidants such as ceruloplasmin, albumin and nontioxidants in order to elucidate antioxidative mechanisms of red ginseng. The treatment with total saponin of red ginseng significantly devreased the contents of malondialdehyde and total free radicals in the liver. On the other hand, total saponin of red ginseng significantly increased the activities of SOD, catalase and GSH reductase and nonprotein-SH level. These results suggest that total saponin of red ginseng exerts an antioxidative effect by increasing endogenous antioxidants.
최진석,이원갑,김동수,최홍대,최재수,정지형,임광식,최원철,손병화,Choi, Jin-Seok,Lee, Won-Kap,Kim, Dong-Soo,Choi, Hong-Dae,Choi, Jae-Sue,Jung, Jee H.,Im, Kwang-Sik,Choi, Won-Chul,Son, Byeng-Wha 한국생약학회 2000 생약학회지 Vol.31 No.2
In order to screen new radical scavenging principle which is expected to be antiaging drug lead, we have investigated 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the marine microalgae, greenalgae(10 speices), diatom (10 speices) and blue-green algae (10 speices). The significant activities$(IC_{50}:\;<100\;{mu}g/ml)$ were observed in 4 species of green algae (MA002, 006, 009, 010), 1 species of diatom (MA015) and 5 species of blue-green algae (MA017, 018, 019, 024, 025). Within the scope of family tested, MA009 $(IC_{50}:\;=78\;{mu}g/ml)$, MA015 $(IC_{50}:\;=38\;{mu}g/ml)$ and MA019 $(IC_{50}:\;=41\;{mu}g/ml)$ displayed the most significant activity. Among the marine microalgae tested at family level, cyanophycean blue-green algae was shown to be the most active family on screening of new bioactive compounds.
장은하(Eun Ha Chang),제남경(Nam Gyung Je),임광식(Kwang Sik Im) 대한약학회 1996 약학회지 Vol.40 No.2
Glycosidation of 20(S)-protopanaxadiol obtained by the alkaline hydrolysis of total ginsenosides with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide in the presence of CdCO3 in benzene-dioxane gave a mixture of acetylated monoglucosides and diglucosides in a total yield of 68%. Under the same condenstion condition, 20-dehydroxyglucosides were formed by dehydration of 12-O-glucosides. The structures of produced glycosides were elucidated as 3-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, 12-O-beta-D-glucopyranosyl-dammar-20(22), 24-dien-3beta,12 beta-diol, 3,12-di-O-beta-D-glucopyranosyl-dammar-20(22), 24-dien-3beta, 12beta-diol, respectively.