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Flow Cytometric Analysis of Nuclear DNA Content in Sinonasal Inverted Papilloma
이흥만,최충식,이상학,최건,황순재 대한비과학회 1995 Journal of rhinology Vol.2 No.1
Inverted papillomas of the nose and paranasal sinuses are multifocal tumors of unknown etiology that have a high recurrence rate and invasive growth pattern. Inverted papillomas tend to transform into malignant tumor. Early diagnosis and aggressive surgical therapy are thus essential. Flow cytometric analysis of nuclear DNA content from paraffin-embedded specimens has been introduced as an important diagnostic and prognostic methods in clinical and investigative oncology. We analysed nuclear DNA content in order to detect possible alternations in DNA histogram as a prognostic indicator of the malignant transformation of the inverted papilloma. The results were as follows: 1) Normal nasal mucosa and inverted papilloma showed diploidy, but squamous cell carcimoma of the maxillary sinus showed aneuploidy. 2)Mean values of S+G₂M% in normal nasal epithelia, inverted papilloma, and squamous cell carcinoma were 10.2%, 19.2% and 29.4%, respectively and the differences between them were statically significant. It was suggested that the presence of aneuploidy and increased S+G₂M% might be good prognostic indicators of malignant change of inverted papilloma.
Immunohistochemical Classification and Clinical Evaluation of Nasal Malignant Lymphoma
이흥만,최충식,최건,조재훈,김철환,이상학 대한비과학회 2000 Journal of rhinology Vol.7 No.1
Background and Objectives:Polymorphic reticulosis (PMR), a type of lethal midline granuloma, has characteristics ofnecrosis, angiocentricity, and angiogenesis, which is also known as nasal T-cell lymphoma. In this study, we classified PMRand nasal lymphoma using immunohistochemical staining and investigated the clinical characteristics of nasal malignant lymphomaincluding survival rates with treatment modalities. Materials and Methods:Twenty-six patients previously diagnosedwith PMR or nasal lymphoma from May 1992 to April 1997 were included in this study. We performed immunohistochemicalstaining with CD3, CD56 and CD79a for classification and reviewed the patients’ clinical characteristics and survival rates, retrospectively. Results:Of twenty-six patients, twenty-five patients were classified as having angiocentric lymphoma and onlyone patient with B-cell lymphoma. Higher mortality rates were observed in patients receiving chemotherapy alone than in thosereceiving chemotherapy and radiation therapy and in advanced stage. Conclusions:Early detection and combined treatmentcould improve the survival rate of patients with nasal malignant lymphomas.
Primitive Neuroectodermal Tumor of Nasal Cavity:Case Report
이흥만,한승훈,우정수,조성진,김한겸,이상학 대한비과학회 1997 Journal of rhinology Vol.4 No.1
The primitive neuroectodermal tumor is a highly malignant small round cell tumor characterized by neuroectodermal originand poor prognosis. The thoracopulmonary region is known to be the most common site of the disease, with peak incidenceduring adolescence. Primitive neuroectodermal tumors are very rarely reported in the head and neck area, and there have beenonly a few involving the nasal cavity. We treated a 60 year-old female patient who had nasal obstruction over a three-monthperiod with radical surgery and postoperative radiation therapy. This paper presents our diagnostic workup and approach intreating this unique tumor, and the immunohistochemical findings. A guideline for the treatment of this aggressive neoplasm isreviewed with our experiences in treating this primitive neuroectodermal tumor of the nasal cavity by combined treatmentmodalities.
이흥만 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.6
Chronic rhinosinusitis is characterized by chronic inflammation of the nasal and paranasal mucosae and is currently classified into two major subgroups on the basis of the absence or presence of nasal polyps. A distinct set of inflammatory and remodeling factors has been found elevated in chronic rhinosinusitis. Transforming growth factor-β and matrix metalloproteinases are critical factors involved in the remodeling process. Transforming growth factor-β has been implicated as an important factor in remodeling processes involved in chronic rhinosinusitis, and serves as a main switch for different remodeling patterns in chronic rhinosinusitis.
Heat Shock Protein 72 Expression Following Odor Exposure in Olfactory System of Rat
이흥만,김효열,최충식,이상학 대한비과학회 1999 Journal of rhinology Vol.6 No.2
Background and Objectives:Heat shock proteins (HSPs) are group of evolutionary conserved proteins whose synthesisare greatly enhanced in cells following exposure to various stressors and play an important role in cellular protection and survival. The purpose of this study was to determine whether olfactory stimulation induces the synthesis of HSP72 in olfactory system ofthe rat. Materials and Methods:Animals were exposed to odorant stimuli using 2% propionic acid odorant stimuli and expressionpattern of HSP72 in the olfactory system were detected by immunohistochemistry using anti-HSP72 antibody accordingto time course and by Western blotting. Results:HSP72 immunopositive cells were expressed in the olfactory epithelium andin the olfactory bulb neurons and a 72 kD band was detected by Western blotting. Conclusion:These results suggest that expressionof HSP72 in olfactory system of the rat following exposure to odor may serve as a marker for cellular stress and potentialdamage and may be involved in cellular protection against injuries.