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Co-nested Polymerase Chain Reaction 법과 Hybrid Capture법을 이용한 Cervical Scrape Specimen에서의 인유두종 바이러스 검출
박종택,심재욱,홍수정,안현경,이환견,정환욱,박인서,문인걸,한인권 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.1
Human papillomavirus(HPV) has implicated in the development of cervical cancer. Several studies have suggested a strong correlation between HPV 16, 18 and cervical intraepithelial neoplasia(CIN). Co-nested polymerase chain reaction(Cn-PCR) technique which is more sensitive 2-step PCR than 1-step PCR was developed to simultaneous detection and typing of HPV by using general and nested general primer pairs localized within the Ll region and general and nested 16, 18 type specific primer pairs localized within the E6ORF. This study was performed to determine the validity of the Cn-PCR method for HPV detection and potential clinical uses as screening method for the identification of CIN and compare with Hybrid capture method. Papanicolaou test and Cn-PCR and Hybrid capture test for HPV infection were performed on 298 women visited for cervical caner screening. Among these cases, 167 cases of persistent atypical squamous cell undertermined significance(ASCUS), cervical erosion and abnormal cytologic result above low grade squamous intraepithelial lesion(LSIL) were histologically confirmed. Comparing the positive rate of HPV among patients with CIN and cervical cancer, there was a significant positive correlation between the positive rate of HPV type 16,18 and the degree of histologic malignancy(P$lt;0.01). The sensitivity of HPV type 16, 18 by using Cn-PCR for CIN grade II, III and cancer was 46%, whereas the corresponding value for the Hybrid capture was 77%. But HPV type 16, 18 were strongly predictive of high grade CIN. The sensitivity and positive predictive value of combination test with cytology and Cn-PCR were 90% and 71%, whereas the corresponponding values of same test modality with Hybrid Capture were 94% and 41%. Then some combination of the two modalities will produce better performance than either alone, but there was no significant difference in sensitivity between the combination of Cn-PCR and cytology test and same combination with Hybrid capture and the positive predictive value was higher in combination Cn-PCR and cytology test. From these results, We confirmed that Cn-PCR is sensitive and reliable method for the helpful in determining which women with mildly abnormal smears have high-grade underlying lesions in need of immediate referral for colposcopy.
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조기 양수천자술과 중기 양수천자술의 안정성에 관한 비교연구
안현경(HK Ahn),류현미(HM Ryu),김문영(MY Kim),김은성(ES Kim),송하균(HK Song),이환견(HK Lee),한정렬(JY Han),김진미(JM Kim),최수경(SK Choi),한호원(HW Han) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1
We sought to determine whether early amniocentesis is a safe and acceptable method of genetic evaluation in early pregnancy. During the 20-month period from February 1994 to September 1995, 80 consecutive early amniocentesis were performed transabdominally at 12+3-14+6 weeks of gestation and 305 consecutive mid- second-trimester transabdominal amniocenteses were performed at 16+0- 18+0 weeks of gestation. All amniotic fluid samples were cultured using flask method. There were no significant differences between the early and mid-second- trimester amniocenteses in failed sampling, ambiguous results, pregnancy loss within 4 weeks after the procedure, pregnancy loss from 4 weeks after procedure to 28 weeks of gestation, preterm birth, and perinatal death. We may conclude that early amniocentesis is a safe and acceptable method for prenatal diagnosis.
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