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이홍선,송호섭,Lee, Hong-Sun,Song, Ho-Sueb The Korean AcupunctureMoxibustion Medicine Society 2008 대한침구의학회지 Vol.25 No.2
목적 : 이 연구는 봉약침의 봉독과 그 주요성분인 멜리틴이 $NF-{\kappa}B$의 활성억제와 세포자멸사 관련 단백질의 발현 조절을 통하여 세포자멸사를 유도하고 전립선 암세포주인 LNCaP 세포의 성장을 억제하는지를 확인하고 해당 기전을 살펴보고자 하였다. 방법 : 봉독이나 멜리틴을 처리한 후 LNCaP의 성장억제를 관찰하기 위해 WST-1 assay, CCK-8 assay를 시행하였고, 세포자멸사의 관찰에는 DAPI, TUNEL staining assay를 시행하였으며, 세포자멸사 조절단백질의 변동 관찰에는 western blot analysis를 시행하였고, 세포자멸사와 연관된 $NF-{\kappa}B$의 활성 변화를 관찰하기 위해 EMSA를 시행하였으며, LNCaP에서 봉독이나 멜리틴과 $NF-{\kappa}B$의 상호작용을 관찰하기 위해 transient transfection assay를 시행 시 세포생존율과 $NF-{\kappa}B$의 활성 변동을 측정하였다. 결과 : LNCaP 세포에 봉독이나 멜리틴을 처리한 후, 전립선암세포의 성장, 세포자멸사의 유발, 세포자멸사 관련 단백질의 발현, $NF-{\kappa}B$의 활성, $NF-{\kappa}B$의 p50 치환 후 $NF-{\kappa}B$의 활성과 LNCaP 세포 증식에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. LNCaP 세포에서 봉독이나 멜리틴을 처리한 후 세포자멸사가 유도되어 세포성장이 억제되었고, 세포자멸사 관련 단백질 중 분리된 PARP, caspase-9, Bax는 유의한 증가를, Bcl-2, p-Akt, MMP 13, XIAP, cXIAP는 유의한 감소를 나타내었다. 2. LNCaP 세포에서 봉독이나 멜리틴을 처리한 후 $NF-{\kappa}B$의 활성의 유의한 감소를 나타내었다. 3. LNCaP 세포에서 $NF-{\kappa}B$ p50를 치환하여 작용기를 없애고 봉독이나 멜리틴을 처리하였을 경우에도 $NF-{\kappa}B$의 활성의 유의한 감소를 나타내었다. 결론 : 이상의 결과는 봉독이나 멜리틴이 $NF-{\kappa}B$의 활성 억제를 통하여 인간 전립선암세포주인 LNCaP의 세포자멸사를 유발함으로써 증식억제 효과가 있음을 입증한 것으로 전립선암의 예방과 치료에 대한 효과적인 치료제 개발에 도움이 될 것으로 기대된다. 다만 그 기전에서 봉독이나 멜리틴은 기존연구와 달리 $NF-{\kappa}B$ p50의 작용기와 직접적으로 상호작용을 하지는 않는 것으로 보이므로 심화 연구를 요한다.
표재성 지방흡입술을 이용한 액취증 수술의 치료 효과에 대한 연구
이홍선 ( Hong Sun Lee ),박건 ( Kun Park ),손숙자 ( Sook Ja Son ),김성언 ( Seong Eon Kim ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.8
Background: Axillary osmidrosis is characterized by unpleasant odor, profuse sweating and occasionally staining of clothes. Classical surgical treatment of axillary osmidrosis may result in many complications, such as scarring, hematoma and necrosis. Objective: The purpose of this study is to evaluate the effect of superficial liposuction in the treatment of axillary osmidrosis. Methods: Through two 5 mm sized incisional windows, liposuction can be done in a two directional criss-cross pattern. Fifteen patients received this surgery for bilateral axillae on an outpatient basis. The follow-up period ranged from 8 months to 18 months, the mean follow-up period was 12.5 months. Results: Of the 30 axillae, 28 axillae (93%) had excellent to good results. The axillary scars were short and nearly negligible (90%). Complications including one minor wound infection (3.3%) and one hematoma (3.3%), were improved with proper post-operative treatment. Four patients experienced transient fibrotic bands. All of these complications disappeared after 1∼2 months. Conclusion: In axillary osmidrosis, superficial liposuction has the merits of high success rates, short scars, minimal postoperative care with a short term of compressive dressing and rapid recovery to normal life. (Korean J Dermatol 2007;45(8):785∼790)
이홍선(Lee Hong-Sun),천세영(Cheon Se-Young),임태형(Lim Tae-Hyeong),김승수(Kim Sung Su),최정주(Choi Jeong Ju),양순용(Yang Soon-Young) 한국생산제조학회 2007 한국생산제조학회지 Vol.16 No.3
The excavator is complex machinery which has widely used in the construction site, deck of harbor and deep sea. The one of important issue of excavator system in recent is an automation of it in order to improve a working efficiency, a convenience working circumstance and work satisfaction. However, since there are large nonlinearities of control circuit, actuating cylinder, joiners of hydraulic units and changing loads etc., it is difficult to develope an automatic excavator system. Therefore, in this study, toy scale pneumatic excavator system is constructed and the remote control system is installed on it, before developing the automatic excavator system. In order to design the control system of the developed pneumatic excavator system, the transfer function is obtained using signal processing method and the controller gains of PID are decided based on CDM(coefficient diagram method). The obtained transfer function and the performance of the proposed control system is evaluated through experiments and computer simulation.
이형래 ( Hyung Rae Lee ),김미선 ( Mi Sun Kim ),한태영 ( Tae Young Han ),손숙자 ( Sook Ja Son ),이현경 ( Hyun Kyung Lee ),이홍선 ( Hong Sun Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.3
Background: Recently, tattooing of the body has become popular, and its associated psychological, sociological, and cultural implications have changed compared to past years. However, little is known about the current clinical features, including motive and satisfaction for having a tattoo, because of societal repulsions toward the practice. Objective: To evaluate the clinical manifestations of tattooed young Korean males and to compare the findings with previous studies. Methods: Between September 2010 and July 2011, 223 patients with tattoos who visited the Eulji Medical Center and Armed Forces Yangju Hospital were selected. The patients were evaluated through a self-administrated questionnaire and physical examinations. Results: The majority of patients were classified into the did not complete university education group (56.1%). Most tattooed males had two living parents (83.4%) and were raised in households whose income statuses were not marked by poverty. The average age at which their first tattoo was received was 19.0 years. Most tattooed males had a negative attitude towards their tattoos (67.3%). The most common motivation for getting a tattoo was curiosity, but cosmetic purposes were also important (19.4%). A majority of the tattooing was conducted by a tattoo artist (73.3%). The most common tattoo content was letters. Black-colored tattoos were most frequently observed. The complication rate was 13.9%. The most common motivation for tattoo removal was negative comments that were made at work, in public, and in school (38.2%). Conclusion: Recent patterns of tattooing have changed significantly since previous reports. The satisfaction rate in getting a tattoo was not favorable. Understanding the current clinical features related to tattooing is important and it is necessary for dermatologists to provide professional advice regarding tattooing among young males. (Korean J Dermatol 2012;50(3):212~219)
김미선 ( Mi Sun Kim ),이홍선 ( Hong Sun Lee ),박건 ( Kun Park ),손숙자 ( Sook Ja Son ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.4
Spiny keratoderma is a dermatosis consisting of multiple projections located on the palms and soles with a distinct histology characteristic of a parakeratotic column. This disease has been associated with various underlying benign or malignant diseases. We report a case of a 72-year-old female patient with spiny keratoderma associated with diabetes mellitus and hypothyroidism. (Korean J Dermatol 2008;46(4):511~513)