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- 저자 : 이홍균(Hong Kyoon Lee) (검색결과 45 건)
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자간전증의 병인에 있어서 VEGF ( vascular endothelial growth factor ) 가 혈관 내피세포에 미치는 영향
조용균(Yong Kyoon Cho),이홍균(Hong Kyoon Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
Objective : Preeclampsia is primarily a disorder of the maternal endothelium. The objective of this study was to assess the effect of VEGF on human umbilical vein endothelial cells (HUVEC) in vitro. Methods : The serum concentrations of VEGF in women with preeclampsia and normotensive pregnant women were measured with a sensitive and specific enzyme immunoassays. After HUVEC were isolated and cultured in vitro, these HUVEC were stimulated with VEGF, sera from women with preeclampsia and normotensive pregnant women for 24 hours. And then prostacyclin levels were measured. Results : The serum concentrations of VEGF were significantly higher in women with preeclampsia than in normotensive pregnant women. Vascular endothelial growth factor induced a significant concentrationdependent increase in prostacyclin production. HUVEC stimulated with sera from women with preeclampsia showed an increase in production of prostacyclin. VEGF concentration in serum was correlated with prostacyclin production by the stimulated cells. Conclusion : VEGF may be one of the circulating factors that cause the alteration in endothelial function and the high serum concentration of VEGF is thought to be important in the pathogenesis of preeclampsia.
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박교훈(Kyo Hoon Park),이홍균(Hong Kyoon Lee),이혁(Hyeok Lee),한정훈(Jeong Hoon Han),조용균(Yong Kyoon Cho),최훈(Hoon Choi),김복린(Bok Rin Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.11
Objective: Our purpose was to evaluate the effect of epidural anesthesia on labor course. Methods: Between January 1998 and December 1998, we evaluated pregnant women at term with singleton fetus in vertex presentation and with spontaneous onset of labor at our hospital. Comparison of 120 women (100 cases of primiparous women, 20 cases of multiparous women) who received epidural anesthesia in labor with 120 women (100 cases of primiparous women, 20 cases of multiparous women) who did not receive epidural anesthesia was performed. Adverse pregnancy outcomes were obtained from hospital delivery records and neonatal records. Statistical analysis were performed by Student's t-test and Chi square test. Results: The results of this study were as followings; 1. There was no significant difference in mean age, body weight, height, and gestational age between epidural anesthesia group and control group (P>0.05). 2. The frequency of oxytocin augmentation was significantly greater in the primiparous epidural anesthetic group than in primiparous control group (p<0.05). 3. The effect of epidural anesthesia on the first stage of labor revealed no significant difference in both group. 4. Prolongation of second stage of labor was noticed in nullipara of epidural anesthesia group compared to control group (P<0.05). 5. The incidence of instrumental delivery was significantly increased in the primiparous epidural group than in the primiparous control group(p<0.05). 6. The meconium-stained amnionic fluid, Apgar score and birth weight were similar in both groups. 7. The maternal blood loss was similar in both groups. Conclusion: Epidural anesthesia, significantly prolongs second stage of labor in induced patients. While instrumental delivery was more prevalent in these parturients, C-section rate and intra-partum complications were not increased in these patients.
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최훈 ( Hoon Choi ),이홍균 ( Hong Kyoon Lee ),박형무 ( Hyoung Moo Park ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.1
연구목적: 본 역학조사는 제 3차 KEDA 프로그램의 일환으로 한국 폐경여성의 폐경에 대한 태도와 인식을 알기 위해 실시된 연구이다. 연구방식: 본 연구는 대한 폐경학회와 한국 와이어스 공동주관하에 전국의 50-59세 여성중 무작위로 추출된 1201명을 대상으로 한국 갤럽 연구소를 통한 직접적인 대상군의 면담을 통해 이루어 졌다. 결과: 대상군의 평균 폐경연령은 49.7세였다. 대상군의 57%인 680명이 폐경의 원인을 알고 있다고 답하였으며, 73%는 폐경은 자연 노화현상으로 기인한다고 응답하였고 21%는 에스트로젠의 결핍이 그 원인이라고 답하였다. 92%는 폐경후 골다공증의 위험이, 72%는 심혈관 질환의 위험이 높아진다고 답하였다. 폐경후 느끼는 감정에 대해 140명이 응답하였는데, 64.2%는 부정적인 태도를 보였다. 자연 폐경을 경험한 797명의 여성중 89%는 폐경증상중 적어도 하나를 경험하였다고 하였으며, 경험한 증상중 안면홍조(61%)가 가장 많았다. 대부분의 폐경여성(79.8%)은 증상의 완화가 필요하다고 하였으나, 반수이상의 여성(54.8%)이 의료계 종사자에게 상담을 받은 적이 없다고 하였다. 42%의 여성은 폐경으로 성욕이 변하지 않았다고 하였으나, 57%는 감소하였다고 하였고 1%만이 증가하였다고 답하였다. 41.5%의 여성이 폐경후 경험한 질환으로는 고협압, 하지골절, 손목골절, 척추골절이었다. 전체 대상군중 33.9%는 규칙적인 운동을 하고 있다고 하였다. 384명(32%)이 칼슘을 복용하고 있다고 하였으며, 277명(23.1%)은 대체의학 또는 건강식품을 복용한 적이 있다고 하였다. 결론: 우리나라 폐경여성이 폐경에 대한 인식을 보면 일부는 치료가 필요하다고 한 반면, 다른 한편으로는 자연적인 방법에 의해 조절되는 자연현상으로 생각하고 있다. 폐경여성에게 체계적인 접근을 통하여 폐경에 대한 정확하고 최신정보를 제공할 필요가 있다고 사료된다. This epidemiologic study was designed to assess Korean menopausal women`s attitudes and awareness on menopause as a part of 3rd Korean Estrogen Deficiency Awareness(KEDA) anniversary program. Design : This study was conducted by Korea Gallup under the auspices of Korea Society of Menopause and Wyeth Korea through the face to face interviews with 1201 women aged between 50 and 59 years, who were randomly recruited from all areas in Korea, by using 53 questionnaires about menopause and HRT. Results : The mean age of menopause of the subjects is 49.7 years. 680 women comprising 57% knew the cause of menopause ,most of them mentioned menopause was the natural again process (73%) or resulted from estrogen deficiency (21%). Most women believed the risk of osteoporosis (92%) and cardiovascular disease (72%) were in creased after menopause. Among 140 menopause women who responded the attitude toward menopause, 64.2% of respondents expressed negative feeling. Among 797 women who experienced natural menopause, 89% of women said they had experienced one of menopausal symptoms and hot flush (61%)was the most common symptom. Most of the (79.8) believed the relief of symptoms was necessary, while more than half of women (54.*) had never been advised of their menopausal symptoms by medical personnel. 42% of women said their sexual desire had remained the same as before menopause, 57% reported their sexual desire had decreased, while 1% said their sexual desire had increased. During menopausal period, 41.5% of women had suffered from hypertension, leg fracture, wrist fracture, or vertebral fracture. Of total cohort, slight more than one third (33.9%) had regular exercise. 384 women (32%) and 277 women (23.1%) had taken calcium supplementation and alternative medicine, respectively. Conclusion : Menopausal women are divided in their view of menopause, some seeing it as a medical condition requiring treatment, whereas others see it as a natural transition to be managed by natural means. Providing menopausal women with accurate, up-to-date information by a systematic approach is required.
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김정연,조혜제,조경자,이홍균,Kim, Jung-Yeon,Cho, Hye-Jae,Cho, Kyung-Ja,Lee, Hong-Kyoon 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
We have investigated the cervicovaginal smears in order to define the cytologic features of uterine adenocarcinomas. Total 22 cases were reviewed(12 cases from the Sanggye Paik hospital, Inje university and 10 cases from the Korea Cancer Center Hospital) from January 1992 to December 1997. Five cases were endometrial adenocarcinomas and the remaining 17 cases were cervical adenocarcinomas. Seventeen cases of cervical adenocarcinomas were divided into endometrioid(6 cases), endocervical(7 cases), mixed endometrioid and endocervical(1 case), papillary (2 cases), and adenosquamous(1 case) carcinomas. The background of endocervical adenocarcinoma was hemorrhagic or inflammatory. The tumor diathesis was less prominent than that of the squamous cell carcinoma. The prominent features of the endocervical type adenocarcinomas were large and loose clusters, large intracytoplasmic vacuoles, and prominent overlapping and peripheral palisading of nuclei. In contrast, the endometrioid adenocarcinomas showed small and compact clusters, and small intracytoplasmic vacuoles. The detection rate of endometrial adenocarcinoma was lower than that of the endocervical adenocarcinoma.
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강웅선 ( Woong Sun Kang ),이철민 ( Chul Min Lee ),임성직 ( Sung Jig Lim ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Rin Kim ),이홍균 ( Hong Kyoon Lee ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
Mature cystic teratoma comprises approximately 10-20% of all ovarian neoplasms and malignant transformation from mature cystic teratoma is reported to be less than 2%. Squamous cell carcinoma is the most frequent malignancy (80%) arising in mature cystic
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한국 폐경여성의 호르몬 대체 요법에 대한 인지도와 수용성에 대한 연구 - 폐경과 호르몬 대체요법에 대한 한국 갤럽 역학연구 조사 결과
박형무(Hyoung Moo Park),최훈(Hoon Choi),이홍균(Hong Kyoon Lee) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A Objective: This epidemiologic study was designed to assess HRT awareness and acceptance in Korean postmenopausal women as a part of 3rd Korean Estrogen Deficiency Awareness (KEDA) anniversary program. Design: This study was conducted by Korea Gallup under the auspices of Korea Menopause Society and Korea Wyeth through the face to face interviews with 1201 women aged between 50 and 59 years, who were randomly recruited from all areas in Korea, by using questionnaire consisting of 53 items of question about menopause and HRT. Results: Of total cohort, slightly more than half reported they were aware of HRT. HRT awareness was strongly and significantly influenced by educational level, household income and living area. Among 938 women without menstruation, 228 women comprising 24.3% had ever used HRT, which was the total of 23.3% of natural menopausal women and 29.8% of hysterectomized women. Forty-four percents of ever-users of HRT, were currently using HRT and 56% were past-users. Nearly one-tenth of women with natural menopause were currently using HRT, while 19% of hysterectomized women were current-users. Ever and current use of HRT was more common after hysterectomy. Sixty-four percents of ever-users reported major motivation to take HRT was doctor's recommendation. Twenty-eight percents were recommended by relatives and friends while 8% were recommended by media such as radio, TV and press. Primary reason for never initiating therapy was no or mild menopausal symptom. Second most common reason was therapy seemed to be not natural and ignorance of HRT. Among past users of HRT, primary reason for stopping HRT was undesirable side effects from the medication. Next most common reason was medication seems to be troublesome and complicated, third most common reason was resolution of symptom. Near one-third of ever-users of HRT started medication soon after menopause and slightly more than half started within 1 year after menopause. Of ever-users of HRT, slightly more than half stopped within 1 year. Three-quarters consulted by gynecologist for prescription of HRT, 18% internist, 4% general practictioner. As basal lab test for HRT, 81% had pap smear, 76% had mammography and 48% had a bone density assessment. Eighty-six percents of ever-users reported HRT was effective for treatment of climacteric symptoms but 14% reported it was ineffective. Conclusion: Even slight more than half of women were aware of HRT, the rate of ever-use was 24.3% and that of current-use was only 10.8%. Therefore we should improve the prescription rate and compliance rate of HRT through continuous education for doctors and postmenopausal women.
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