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이현호,최세준,김기정,초형석,김성윤,성기욱 대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.5
Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine (DA) on the corticostriatal synaptic transmission using in vitro extracellular recording technique in rat brain corticostriatal slices. Synaptic responses were elicited by stimulation of cortical glutamatergic inputs on the corpus callosum and recorded in the dorsal striatum. Corticostriatal population spike (PS) amplitudes were decreased (39.4±7.9%) by the application of 100μM DA. We applied receptor subtype specific agonists and antagonists and characterized the modulation of corticostriatal synaptic transmission by different DA receptor subtypes. D2 receptor agonist (quinpirole), antagonist (sulpiride), and D1 receptor antagonist (SKF 83566), but not D1 receptor agonist (SKF 38393), induced significantly the reduction of striatal PS. Pretreatment neither with SKF 83566 nor sulpiride significantly affected corticostriatal synaptic inhibition by DA. However, the inhibition of DA was completely blocked by pretreatment with mixed solution of both SKF 83566 and sulpiride. These results suggest that DA inhibits corticostriatal synaptic transmission through both D1 and D2 receptors
두 가지 Calcium Hydroxylapatite(Radiesse versus Facetem)를 이용한 Injection Laryngoplasty의 단기 음성 결과의 비교연구
이현호,박성준,박영학 대한이비인후과학회 2019 대한이비인후과학회지 두경부외과학 Vol.62 No.10
Background and Objectives Radiesse® is a widely used calcium hydroxyapatite (CaHA)injection material used for vocal fold injection. Recently, a new CaHA injection material (Facetem®) which complements the structural disadvantages of Radiesse has been developed andreleased in the market. The aim of this study is to compare the efficacy and short-term voiceoutcome of these two CaHA materials. Subjects and Method A retrospective analysis was performed for 70 patients with unilateralvocal fold paralysis who underwent vocal fold injection using CaHA materials. Acousticvoice analysis, maximal phonation time (MPT), voice handicap index (VHI), and Grade,Roughness, Breathiness, Asthenia, Strain (GRBAS) scale were evaluated between Radiesseand Facetem injection group. Results Both groups showed a signifcant improvement of MPT, VHI, and G, B, A scale afterinjection. The Facetem group showed similar voice improvement as the Radiesse group,where pre- and postoperatively objective and subjective voice evaluation results were compared. Conclusion Our study reveals that there is no significant difference in efficacy and nor anyshort-term vocal improvement between Radiesse and Facetem. Therefore, the use of Facetem asCaHA injection material could be considered as an alternative material for patients with unilateralvocal cord paralysis.
이현호 한국공간구조학회 2019 한국공간구조학회지 Vol.19 No.2
This study proposes a technique to dissipate the energy of a rocking wall installed on a frame by using a metallic damper. The rocking behavior is to turn left and right about the wall vertical axis. The development system is a method of dissipating energy by installing a damper which is the like on a large displacement portion. Experimental results showed that in case of shorter strut make strength capacity increasement and in case of longer strut make deformation capacity increasement. The higher the strut height, the better the energy dissipation capacity. The proposed equation for estimating the steel damper strength applied to this study is a straight type strut damper. However, it is not suitable for calculation of the strength of clamped type strut damper where both flexural behavior and shear behavior are mixed.
이현호,Lee, Hyun-Ho 한국공간구조학회 2021 한국공간구조학회지 Vol.21 No.3
In this study, a rocking behavior experiment using a guide plate and a guide channel to prevent lateral deformation of a steel damper was planned. For this purpose, strut I-type specimen I-1 and strut S-type specimen S-1 were prepared. The experimental results were compared with the existing experimental results of SI-260 and SS-260 under the same conditions without the details of lateral deformation prevention in order to evaluate the effect of preventing lateral deformation. The damper with lateral deformation prevention detail was evaluated to have superior strength capacity, deformation capacity, and energy dissipation capacity than the damper without it. Therefore, the lateral deformation prevention detail was evaluated to have a good effect in improving the design capability of the steel damper.