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소아, 청소년 옴 감염에 대한 임상적 고찰: 10년간의 후향적 단일기관 연구
김영신 ( Young Shin Kim ),이현경 ( June Hyunkyung Lee ),최재은 ( Jae Eun Choi ),한태영 ( Tae Young Han ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.4
Background: Scabies is a parasitic infection caused by the Sarcoptes scabiei var. hominis mite. Its incidence has been increasing in recent years; however, no study has evaluated the clinical aspects of scabies in children and adolescents in Korea. Objective: To evaluate the clinical characteristics and epidemiological features of scabies among children and adolescents and to investigate the clinical efficacy of topical therapies for the treatment of scabies. Methods: We retrospectively reviewed the medical records of 62 patients under 18 years of age with scabies during a 10-year-period. Results: Sixty-two patients with 62 scabies were investigated. These patients showed scabies mites or eggs under microscopic examination or showed clinical improvement after treatment. There were 36 boys (58.1%) and 26 girls (41.9%). The mean age of the boys was 9.3 years and that of the girls was 8.2 years. The most common primary lesions were erythematous papules (93.5%), and the commonest sites of the skin lesions were the hand (64.5%) and the trunk (61.3%). The most common suspected mode of transmission was through contact among families living together. The mean time to complete treatment was 46.1 days using 1% gamma benzene hexachloride lotion, 37.1 days using 10% crotamiton ointment, and 22.8 days using 5% permethrin cream. Conclusion: We confirmed the epidemiological features and clinical characteristics of scabies in children and adolescents, including contact sources and treatment. This study could provide useful data for the prevention and management of scabies in children and adolescents. (Korean J Dermatol 2021;59(4):259∼265)
유미 ( Mi Yu ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook Ja Son ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Background: Acute generalized exanthematous pustulosis (AGEP) is a rare disease mostly related to drug eruption. The skin lesions present as widespread sterile pustules on erythematous bases, usually accompanied by fever and leukocytosis. Case History: A 62 year old woman presented with generalized multiple tiny pustules and erythematous confluent patches on the trunk and proximal extremities. Two weeks ago, a sodium salicylate agent was injected at a local clinic to subside chilling sensation. The skin lesion appeared 10 days after the injection and was accompanied by a high fever. Results: Laboratory tests revealed leukocytosis and elevated erythrocyte sedimentation rate. The histopathological examination of the skin biopsy specimen showed subcorneal spongiform pustules with perivascular inflammatory cell infiltration. The patient was diagnosed with AGEP and treated with systemic steroids and antihistamines. The lesion resolved after 3 weeks. Conclusion: Herein, we report a rare case of AGEP induced by sodium salicylate injection. (Korean J Asthma Allergy Clin Immunol 2011;31:304-306)
디클로로아세트산으로 치료한 유륜에 발생한 피지샘증식증 1예
유미 ( Mi Yu ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook Ja Son ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.11
Sebaceous hyperplasia is a common disease in middle-aged adults. The lesions usually present as solitary or multiple yellowish tiny papules on the face. The areola, vulva and penis are rarely reported sites for this malady. There is no definitely successful treatment for sebaceous hyperplasia. A 35-year-old woman presented with a one-year-history of numerous asymptomatic tiny confluent papules arranged in yellowish plaques surrounding both nipples. Histologic examination showed multiple clustered sebaceous lobules around a centrally located, dilated sebaceous duct. The lesion was treated by applying dichloroacetic acid. After 6 weeks, the lesion had resolved leaving faint postinflammatory hypopigmentation. Herein, we report a rare case of areolar sebaceous hyperplasia that was treated with dichloroacetic acid. (Korean J Dermatol 2011;49(11):1046∼1048)
유미 ( Mi Yu ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook Ja Son ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.5
Basal cell carcinoma (BCC) located on the vulva, accounts for less than 1% of BCC, and it may display more invasive, aggressive features. The clinical manifestations are variable, and symptoms, such as pruritus and irritation can be noted. Vulvar malignant melanoma, which is the second most common vulvar malignancy, is characterized by asymmetry, border irregularity, color variegation, large diameter and commonly reported symptoms like pain, itching, discharge or bleeding. A 50 year-old woman presented with a 3-year-history of pruritic variegated colored, 2 cm sized plaque on the right labia majora and a 74 year-old woman presented with a 8-year-history of easily-bleeding black colored 1.7 cm sized plaque on the left labia majora. Histologic examinations showed a downward growth of basaloid tumor cells, with peripheral palisading. Two patients were diagnosed as BCC on a vulvar area, and the lesions were widely excised with clear resection margin. Herein, we report two cases of vulvar BCC, clinically mimicking a malignant melanoma. (Korean J Dermatol 2012;50(5):436∼439)
혈액학적 이상 소견이 없는 환자에서 발생한 조직구양 Sweet 증후군
공태석 ( Tae Seok Kong ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook Ja Son ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.7
Histiocytoid Sweet syndrome (HSS) is a recently described rare variant of acute febrile neutrophilic dermatosis. HSS is clinically characterized by painful inflammatory plaques or nodules with high fever and neutrophilia. About 20% of HSS patients also have an associated malignancy, most commonly of hematologic origin. Histopathologically, HSS is characterized by dense histiocytic infiltration with prominent upper dermal edema, and little neutrophil infiltration. A 69-year-old female presented with a 1-week history of painful erythematous plaques on both elbows accompanied by fever. She was diagnosed with acute pyelonephritis and treated with ciprofloxacin for 2 weeks. Routine laboratory tests showed elevated white blood cell count (predominantly neutrophils), erythrocyte sedimentation rate, C-Reactive Protein, and a mildly elevated liver function test. Peripheral blood smears were normal. Histopathologic examination showed papillary dermal edema and diffuse interstitial infiltration of histiocytoid cells. Immunohistochemical studies revealed that the histiocytoid cells were positive for CD 68 and myeloperoxidase. After treatment with systemic glucocorticoids, the skin lesions and fever gradually resolved. Based on the clinical and histopathologic examination, we diagnosed HSS with no evidence of a hematologic disorder. Herein, we report an unusual case of HSS without associated bone marrow dysplasia. (Korean J Dermatol 2015;53(7):552∼555)
공태석 ( Tae Seok Kong ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook-Ja Son ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.1
Pacinian neuroma is a rare skin disease characterized by hyperplasia or hypertrophy of the Vater-Pacini corpuscles which are responsible for the appreciation of deep pressure and vibration. It usually affects the volar aspects of the fingers in middle-aged adults and it produces severe pain and tenderness on the affected skins. About half of previously reported cases revealed the association with precipitating factors such as local trauma, but underlying mechanisms are not established. Two patients presented with a several months history of solitary pale-colored papule on the tip of finger. The patients reported a severe tenderness on the lesion with a history of repetitive trauma. The histopathologic examination from the lesions showed increased number of onion-like stratified structures around nerve fibers, compared to the usual density of pacinian corpuscles (3∼5/cm2). The histopathological features were consistent with pacinian neuroma. The symptoms of the patients disappeared soon after the surgery. Herein, we present two patients with pacinian neuroma on the finger, and we also propose that pacinian neuroma should be considered for the differential diagnosis of tender papule on the digit.
김서완 ( Seo Wan Kim ),공태석 ( Tae Seok Kong ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook Ja Son ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.12
Partial unilateral lentiginosis is a rare pigmentary disorder which is characterized by multiple grouped lentigines in unilateral or segmental distributions. The ocular involvement of the disease is extremely rare and only four cases have been reported until today. The exact pathophysiology is still unknown. An 18-year-old woman is being presented with unilateral hyperpigmented macules on her left forehead, eyelid, cheek, lip and chin which all demarcated sharply at the midline of her face. The lesion has been presented since the age of 1. Also, there are discrete brownish pigmentations on her left bulbar conjunctiva. Biopsy specimen is being obtained from the left chin and the histopathological examinations revealed increasing basal layer of pigmentations and mild elongation of rete ridges. The histopathological features are also consistent with lentigo simplex. Herein, we present a rare case of partial unilateral lentiginosis with an ocular involvement. We have also proposed that the partial unilateral lentiginosis has a possibility of ocular involvements. (Korean J Dermatol 2013;51(12):979∼982)
영아에서 BCG 접종 후 발생한 전신성 고리 육아종 3예
김서완 ( Seo Wan Kim ),공태석 ( Tae Seok Kong ),한태영 ( Tae Young Han ),이현경 ( June Hyunkyung Lee ),손숙자 ( Sook Ja Son ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.4
Generalized granuloma annulare is a rare benign granulomatous dermatosis characterized by disseminated necrobioticdermal papules forming an annular or nonannular configuration. It usually occurs in adults and rarely affects infants. Histologically, it presents as a lymphohistiocytic granuloma associated with varying degrees of connective tissue degeneration. Clinical associations between generalized granuloma annulare and diabetes mellitus, thyroid disease,malignancy, infection, and vaccination have been reported. There are a few cases reports of generalized granulomaannulare associated with Bacillus Calmette-Guerin (BCG) vaccination. Herein, we report three cases of generalizedgranuloma annulare following BCG vaccination in infants.