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수용성 Dimethyl Dimethoxy Biphenylate 유도체의 간염 치료 효과
이치호,문전옥,정경욱,김수현,김남득,이성광,양희선 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.3
A water-soluble DDB derivative (Bis{2-(methylamino)ethyl}-4.4-dimethoxy-5.5', 6.6'-dimethylene-dioxy-biphenyl-2,2'-dicarboxylate, DDB-S) was synthesized and its therapeutic effects on the liver damage induced by carbon tetrachloride in rats were evaluated. Oral administration of DDB-S reduced the aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activities and increased total protein and albumin contents in the serum of the carbon tetrachloride intoxicated rat. Therapeutic effects of DDB-S by intravenous injection was also investigated using carbon tetrachloride intoxicated rats. Histological studies showed that IV injection of DDB-S had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication and also prevented the elevation of liver weight/body weight ratio. IV administration of DDB-S to CCl₄-treated rats significantly decreased AST & ALT activities and also prevented the decrease of aniline hydroxylation activity of the liver. These results indicate that i.v. administration of DDB-S is very effective in recovering the liver function in CCl₄-treated rats.
Chemiluminescence Anlyzer를 이용한 고추씨유, 대두유, 올리브유의 저장기간별 산패치 비교평가
이치호,구효정,김상순,성지민,이지영,정희은,홍유나 한국축산식품학회 2004 심포지움 및 학술발표회 Vol.- No.33
실험결과를 요약하면 다음과 같다. 1. TBA를 비교해본 결과 대두유에 비해 올리브유와 고추씨 기름의 값이 낮았다. 2. 대두유의 CL값은 올리브유나 고추씨기름의 산패도는 대두유에 비해 낮은 값이었다. 3. 이러한 방법을 김에 대해 적용시킨 결과 올리브유와 고추씨 기름이 대두유에 비해 산패를 낮추는 결과를 얻었다. 특히 고추씨 기름은 올리브유보다 산패 억제 작용이 더 크다는 것을 알 수 있었다. 따라서 이러한 결과는 유지와 깊은 관련이 있는 축산식품의 산패방지에 응용할 가치가 있는 것으로 사료된다.
경추 및 요추의 통증에 사용되는 견인요법에 대한 문헌 고찰
이치호,김빛나라,정훈,이현재,이옥진,이은정,오민석,Lee, Chi-Ho,Kim, Bin-Na-Ra,Jung, Hun,Lee, Hyun-Jae,Lee, Ok-Jin,Lee, Eun-Jung,Oh, Min-Seok 척추신경추나의학회 2014 척추신경추나의학회지 Vol.9 No.2
Objectives : This study aims to evaluate domestic/foreign clinical studies related to the traction therapy and analyse points to consider about cervical/lumbar traction therapy. Methods : Seven databases were searched for related articles about cervical/lumbar traction therapy from 1950 to 2014. Fourteen clinical studies and several systemic reviews were included among 144 studies searched. Out of fourteen clinical studies, four were case series and ten were controlled trials. Results : Most of included studies reported favorable effects of traction group compared to baseline of controlled group. The various mechanical factors most relevant to traction are 1) angle of pull and direction, 2) traction force, 3) duration of traction and frequency of treatment. Conclusions : We found various mistake in the applications of statistical methodologies of traction therapy targeting patients of cervical, lumbar vertebral disease. It is necessary for more randomized controlled trials to evaluate effect of cervical/lumbar traction therapy targeting patients of cervical, lumbar vertebral disease.