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난소 종양에서의 MAGE (Melanoma Antigen Gene) 유전자 발현
이천준 ( Chun June Lee ),남영일 ( Young Il Nam ),서자영 ( Ja Young Seo ),이인철 ( In Cheol Lee ),김영환 ( Young Hwan Kim ),김원규 ( Won Gyu Kim ),김흥열 ( Heung Yeol Kim ),김성한 ( Sung Han Kim ),박은동 ( Eun Dong Park ),김영옥 ( 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
목적 : 대부분의 난소암이 진행된 시기에 발견되기 때문에 효과적인 치료법의 대안이 필요하다는 점을 고려할 때 난소암에서 MAGE 유전자 발현을 조사하여 그 발현과 면역 요법의 적절성을 연구하는 것은 난소암의 치료에 의미가 있다고 생각된다. 이에 저자는 정상 난소 조직, 비종양성 난소 질환과 양성 및 악성 난소 종양에서의 MAGE 1-6 common primer를 이용한 nested RT-PCR법으로 MAGE 유전자 발현을 조사하여 MAGE 유전자를 이용 Objective : Chemotherapy of ovarian cancer has a main role in the post-surgical treatment of ovarian cancer. However, relapsing patients are usually resistant to an additional chemotherapy. The development of immunotherapy is therefore needed to offer oth
이천준 ( Chun June Lee ),전창완 ( Chang Wan Joen ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
Pregnancy associated breast cancer is defined as breast cancer diagnosed during pregnancy or in the 12 months postpartum. The incidence is one of the most common carcinomas and approximately 1 in 3,000 pregnancies in the United States. Pregnant women are
이태화 ( Tea Hwa Lee ),이천준 ( Chun June Lee ),김원규 ( Won Gue Kim ),김성한 ( Sung Han Kim ),정민정 ( Min Jung Jung ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10
Paraovarian cysts arise in the mesosalpinx, between the ovarian hilum and the fallopian tube. Clinical significance of paraovarian tumors is considerably less frequent than ovarian tumors, and malignant paraovarian lesions are exceedingly rare. Paraovarian carcinomas or borderline malignancy mostly occur in young women. Abdominal enlargement and pelvic pain are the usual complaints. Usually they have a capsule, are unilateral and are connected to the broad ligament. Little is known about the biological behavior of the paraovarian borderline malignancies, since these lesions are so rare. The appropriate therapy for this unusual lesion have not been fully defined. We had experienced a case of papillary serous adenocarcinoma of borderline malignancy and report this case with a brief review of literature.
최종열 ( Jong Yeol Choi ),이천준 ( Chun June Lee ),김원규 ( Won Gyu Kim ),조성래 ( Sung Rae Cho ),신홍천 ( Hong Chun Shin ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6
Intravenous leiomyomatosis (IVL) with intracaval mass, cardiac extension, and pulmonary metastasis is rare and it is characterized by nodular masses of smooth muscle proliferation that may extend to variable distances. We experienced a case of the intravenous leiomyomatosis originating from the uterus and extending to the ovarian veins, the iliac veins, the inferior vena cava, the right atrium and the lung. And ti was diagnosed from the various preoperative studies and operated successfully through the single-stage approach. So we report it with a brief review of the literature.
이태화 ( Tae Hwa Lee ),이천준 ( Chun June Lee ),김흥열 ( Heung Yeol Kim ),김원규 ( Won Gue Kim ),김성한 ( Sung Han Kim ) 대한주산의학회 2008 Perinatology Vol.19 No.2
Down syndrome is a chromosome related desease that shows mental retardation, growth retardation and many other signs such as defects in the face, hands and skin. Down syndrome is very uncommon in dizygotic twins, especially in twins with different sex. This twin`s chromosomal analysis shows both twins with trisomy 21, but the parents` chromosomal analysis is normal. A 30 year old infertile woman who became pregnant via ICSI(intracytoplasmic sperm injection) has shown dizygotic twins with different sex to have Down syndrome and therefore it is being reported along with simple documents.
항암화학요법 중인 부인암 환자에서 Aprepitant와 Ondansetron요법 간의 효과에 대한 비교 연구
오지영 ( Ji Yeung Oh ),이천준 ( Chun June Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.5
목적: 오심과 구토는 항암화학요법 시 나타나는 주요 부작용으로 새로운 기전의 치료제인 aprepitant를 사용하여 기존의 ondansetron요법에 비하여 얼마나 오심과 구토에 도움이 되는지 알아보고자 본 연구를 하게 되었다. 연구 방법: 고신의과대학 복음병원에서 2007년 3월부터 2007년 10월까지 처음 부인암으로 진단받고 항암화학요법으로 치료중인 61예를 대상으로 전향적으로 연구하였다. Aprepitant요법/ondansetron요법 환자를 오심과 구토유발 항암화학요법후 1일(급성), 2~5일(지연성)으로 나누어 오심과 구토의 정도를 보고 조사하였다. 통계는 chi-square test로 하였다. 결과: Aprepitant요법과 ondansetron요법에서 급성 오심과 지연성 오심은 각각 86.7%, 83.9%(P-value=0.742)와 99%, 83.9%(P-value=0.083)로 나와 두 군간의 통계학적으로 유의성이 없었다. 급성 구토는 aprepitant요법과 ondansetron요법에서 각각 99%, 83.9%로 나와 통계학적으로 유의하지 않았다 (P-value=0.809). 지연성 구토에서 aprepitant요법과 ondansetron요법이 각각 96.7%, 83.9%로 나와 aprepitant요법보다 더 나은 조절효과를 보였으며 두 군 간의 통계학적으로 유의한 차이가 있었다(P-value=0.034). Aprepitant요법과 ondansetron요법에서 부작용은 두 군 간의 통계학적으로 유의성이 없었다. 결론: 구토 유발이 심한 cisplatin 포함한 항암화학요법으로 치료하는 부인암 환자에서 aprepitant요법은 지연성 구토에 효과가 있고 기존의 ondansetron요법과 비교하여 별다른 부작용에 대해서도 안전하게 사용할 수 있다. 따라서 부인암의 오심과 구토유발 항암화학요법 시 ondansetron요법에 aprepitant를 추가하여 사용하는 것이 지연성 구토 조절에 더 좋을 것으로 생각된다. Objective: We compared the impact of chemotherapy-induced nausea and vomiting (CINV) on patients of an aprepitant regimen with an ondansetron regimen, for antiemetic efficacy after highly emetogenic chemotherapy (HEC). Methods: The study was performed prospective on 61 patients who is diagnosed initially the gynecological cancer during chemotherapy at Gospel hospital of Kosin university between March 2007 and October 2007. The study was divided according to an aprepitant/ondansetron regimen. The efficacy of controlling acute (during the 24 hours after chemotherapy)/delayed (day 2 days thought 5) nausea, vomiting and adverse effects were compared. Statistical analysis was performed using the chi-square test. Results: The efficacy of controlling nausea with an aprepitant regimen and an ondansetron regimen was 86.7%, 83.9% in acute periods (P-value=0.742) and 99%, 83.9% in delayed periods (P-value=0.083), respectively. The efficacy of controlling vomiting with an aprepitant regimen and an ondansetron regimen was 93.3%, 90.3% in acute periods (P-value=0.809) and 96.7%, 83.9% in delayed periods (P-value=0.034), respectively. The efficacy of controlling delayed vomiting with an aprepitant regimen reported significantly. The common adverse effects in both groups were not significantly. Conclusion: The regimen including aprepitant was superior in preventing CINV as compared with a regimen in which both ondansetron and dexamethasone were given delayed periods in patients receiving chemotherapy.
김미향 ( Mi Hyang Kim ),이태화 ( Tae Hwa Lee ),이천준 ( Chun June Lee ),김흥열 ( Heong Yeol Kim ),김원규 ( Won Gyu Kim ),김성한 ( Sung Han Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.4
The occurrence of malignant pericardial effusion is rare in squamous cell carcinoma of the uterine cervix. Only six cases of antemortem diagnosis have been reported. We report a patient with squamous cell carcinoma of the cervix who received emergent pericardiocentesis. In a few reported cases, women with pericardial involvement are candidates for radiation or chemotherapy. Early detection and prompt management of pericardial effusion is correlated with better quality of life and a decreased morbidity.