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이창욱,오병훈,Lee, Chang Uk,Oh, Byung Hoon 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1
Visual perception is a complex process engaging many different aspects of brain functioning. Like other cognitive functions, the extensive cortical distribution and complexity of visual perceptional activites make them hihgly vulnerable to brain injury. Dectection and characterization of perceptual disorders require a careful clinical assessment as well as the application of selected neuropsychological tests. In this article we reviewed neuropsychological assessment of visual perception and constructional abilities. And the principal visuospatial disorders are discussed, the associated neuropsychiatric disorders are presented.
화소 기반 형태분석 방법을 이용한 알츠하이머 치매환자의 회백질 용적감소의 정량적 분석
임현국,최은형,이창욱,Lim, Hyun-Kook,Choi, Eun-Hyung,Lee, Chang-Uk 대한생물정신의학회 2008 생물정신의학 Vol.15 No.2
Objectives : The purpose of this study was to find brain regions in which gray matter volume was reduced and to show the capability of voxel-based morphpmetry(VBM) analysis for lateralizing clinically significant brain regions in dementia of Alzheimer's type patients compared to healthy group. Methods : MR T1-weighted images of the 20 dementia of Alzheimer's type patients were compared with those of the 20 normal controls. Images were transformed to standard MNI space. In order to observe gray matter volume change. Gray matter was smoothed with a Gaussian kernel. After these preprocessing, statistical analysis was performed using statistical parametric mapping software(SPM2). Results : Gray matter volume was significantly reduced in the bilateral parahippocampal gyri, Lt. anterior cingulate gyrus, Lt. posterior cingulate gyrus, bilateral superior temporal gyri Lt. middle temporal gyrus, Lt. superior, bilateral middle, Rt. anterior frontal gyri and Rt. precuneus in dementia of Alzheimer's type patient group. Conclusions : These VBM results confirm previous findings of temporal lobe and limbic lobe atrophic changes in dementia of Alzheimer's type, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.
알츠하이머병 환자의 전반적 피질 위축, 내측두엽 위축, 백질 고강도 신호와 인지기능의 연관성
최린,주수현,이창욱,백인호,Choi, Leen,Joo, Soo-Hyun,Lee, Chang-Uk,Paik, In-Ho 대한생물정신의학회 2015 생물정신의학 Vol.22 No.3
Objectives The aim of this study is to investigate the correlation between degenerative changes in brain [i.e., global cortical atrophy (GCA), medial temporal atrophy (MTA), white matter hyperintensities (WMH)] and neurocognitive dysfunction in Korean patients with Alzheimer's disease. Methods A total of 62 elderly subjects diagnosed with Alzheimer's disease were included in this study. The degenerative changes in brain MRI were rated with standardized visual rating scales (GCA or global cortical atrophy, MTA or medial temporal atrophy, and Fazekas scales) and the subjects were divided into two groups according to the degree of degeneration for each scale. Cognitive function was evaluated with Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) and several clinical features, including apolipoprotein E ${\varepsilon}4$ status, lipid profile and thyroid hormones, were also examined. Chi-square test and Fisher's exact test were performed to analyze the relationship between the degree of cerebral degeneration and neurocognitive functions. Results Demographic and clinical features, except for the age, did not show any significant difference between the two groups divided according to the degree of cerebral degenerative changes. However, higher degree of GCA was shown to be associated with poorer performance in verbal fluency test, word list recall test, and word list recognition test. Higher degree of MTA was shown to be associated with poorer performance in Mini-Mental State Examination in the Korean Version of CERAD Assessment Packet (MMSE-KC), word list recognition test and construction praxis recall test. Higher degree of white matter hyperintensities was shown to be associated with poorer performance in MMSE-KC. Conclusions Our results suggest that severe brain degeneration shown in MRI is associated with significantly poorer performance in neurocognitive tests in patients with Alzheimer's disease. Moreover, the degree of GCA, MTA and white matter hyperintensities, represented by scores from different visual rating scales, seems to affect certain neurocognitive domains each, which would provide useful information in clinical settings.
개선된 다구찌 기법을 이용한 BLDC 전동기의 코깅 토크 저감을 위한 강건 최적설계
이창욱(Chang-Uk Lee),김동욱(Dong-Wook Kim),김동훈(Dong-Hun Kim) 한국자기학회 2014 韓國磁氣學會誌 Vol.24 No.5
In this paper, an efficient robust design utilizing an enhanced Taguchi method is proposed to reduce cogging torque of a BLDC motor in the presence of design uncertainty. To overcome defects of the conventional Taguchi method in dealing with a generalized robust design problem, a penalty function and an optimal level searching technique are newly introduced. In order to verify the proposed method, a 5 kW, rated speed of 2,300 rpm, rated torque of 20 Nm BLDC motor for driving electric vehicles is optimized. Then, the robust design is compared with conceptual and deterministic ones in terms of the cogging torque, rated torque and torque ripple.