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Phenobarbital 투여와 성장단계가 흰쥐 간조직 Microsome 내 Monooxygenase System에 미치는 영향
홍영숙,이진순 梨花女子大學校 醫科大學 醫科學硏究所 1988 EMJ (Ewha medical journal) Vol.11 No.3
A variety of compounds including drugs, carcinogens, steroids and fatty acids are metabolized by microsomal monooxygenase system in the liver. The effect of phenobarbital(PB) on the monooxygenase system in the liver microsomes of neonatal, immature- and adult-rats of both sexes were investigated. In the liver microsomes of rats, the activities of cytochrome P-450, NADPH-cytochrome C reductase, cytochrome b_5, NADH-cytochrome C reductase, p-nitroanisole-O-demethylase and the formation of lipid peroxide were assayed : the following results were obtained. 1) In the liver microsomes of rats, the activities of cytochrome P-450 and NADPH-cytochrome C redutase were increased in PB treated rats compared to control. Among the developmental stages, the contents of hepatic microsomal cytochrome P-450 and NADPH-cytochrome C reductase were highest in the female adult rat and the male immature rat. 2) The contents of hepatic microsomal cytochrome b_5 and NADH-cytochrome C reductase were increased in PB treated rats compared to control. Among the developmental stages the content of hepatic microsomal cytochrome b_5 was highest in the female adult rat and the male immature rat, whereas the content of hepatic microsomal NADH-cytochrome C reductase was highest in the adult rats of both sexes. 3) The formation of lipid peroxide was increased in PB treated rats compared to control. Among the developmental stages the formation of lipid peroxide was highest in the female adult rat and the male immature rat. 4) The activity of hepatic microsomal p-nitroanisole-O-demethylase was increased in PB treated rats compared to control. Among the developmental stages the activity of p-nitroanisole-O-demethylase was highest in the female adult rat and the male immature rat.