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이지해,박광훈,김기찬,신찬영,정지혜 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.5
Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors—symptoms that mirror those observed in human autism spectrum disorders (ASD). Overexpression of TERT also alters the excitatory/inhibitory (E/I) ratio in the medial prefrontal cortex. However, the effects of TERT overexpression on hippocampal-dependent learning and synaptic efficacy have not been investigated. In the present study, we employed electrophysiological approaches in combination with behavioral analysis to examine hippocampal function of TERT transgenic (TERT-tg) mice and FVB controls. We found that TERT overexpression results in enhanced hippocampal excitation with no changes in inhibition and significantly impairs long-term synaptic plasticity. Interestingly, the expression levels of phosphorylated CREB and phosphorylated CaMKIIα were significantly decreased while the expression level of CaMKIIα was slightly increased in the hippocampus of TERT-overexpressing mice. Our observations highlight the importance of TERT in normal synaptic function and behavior and provide additional information on a novel animal model of ASD associated with TERT overexpression.
합동과 대칭의 지도를 위한 융합 프로그램 개발 및 적용
이지해,신항균 한국초등수학교육학회 2018 한국초등수학교육학회지 Vol.22 No.3
The purpose of this study is to develop and apply a Convergence program for teaching of congruence and symmetry and to investigate the effects of the mathematical creativity and convergence talent. For these purposes, research questions were set up as follows: 1. How is a Convergence program for teaching of congruence and symmetry developed? 2. How does a Convergence program affect the mathematics creativity and convergence talent of fifth grade student in elementary school? The subjects in this study were 16 students in fifth-grade class in elementary school located in Songpa-gu, Seoul. A Convergence program was developed using the integrated unit design process chose the concept of congruence and symmetry as its topic. The developed program consisted of a total 12 class activities plan, lesson plans for 5 activities. Mathematics creativity test, a test on affective domain related with convergence talent measurement were carried out before and after the application of the developed program so as to analyze the its effects. In addition, students' satisfaction for the developed program was investigated by a questionnaire. The results of this study were as follows: First, A convergence program should be developed using the integrated unit design process to avoid focusing on the content of any one subject area. The program for teaching of congruence and symmetry should be considered students' learning style and their preferences for media. Second, the convergence program improved the students’ mathematical creativity and convergence talent. Among the sub-factors of mathematical creativity, originality was especially improved by this program. Students thought that the program is good for their creativity. Plus, this program use two subject class, Math and Art, so student do not think about one subject but focus on topic ‘congruence and symmetry’. It help students to develop their convergence talent. 본 연구는 합동과 대칭의 지도를 위하여 융합 프로그램을 개발하고, 초등학생에게 적용하여 그 효과를 확인하고자 하였다. 수학 영역에서 학생의 선호도가 가장 높은 합동과 대칭을 주제로 선정하고, Drake의 주제중심 통합단원 수업설계 절차를 토대로 프로그램을 개발하였다. 학습자의 학습 유형을 고려하여 다양한 활동이 가능한 미술 교과와 융합하였으며 초등학교 5학년 학생에게 적용 가능한 활동계획안을 개발하였다. 총 12가지 활동계획안을 개발하고 그 중 5가지 활동의 수업안과 학습지를 학생들에게 적용하였다. 연구대상은 서울시 송파구 소재의 초등학교 5학년 1개 반 16명의 단일집단으로 구성하였다. 개발된 융합프로그램은 학생들의 수학적 창의성과 융합인재소양을 신장시키는 데 긍정적인 영향을 미쳤다.
세침흡인 세포검사로 진단된 인두주위에 발생한 신경절 신경종 - 1예 보고 -
이지신,조향정,윤기중,문형배,Lee, Ji-Shin,Cho, Hyang-Jeong,Yun, Ki-Jung,Moon, Hyung-Bae 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Ganglioneuromas are a fully differentiated tumor that contains no immature elements. The majority of sanglioneuromas are diagnosed in patients older than 10 years and are most often located in the posterior mediastinum, followed by the retroperitoneum. The location of these tumors in the parapharyngeal region is extremely uncommon and there are only a few reports on the cytologic appearance of the tumor. We report a case of ganglioneuroma presenting in a parapharyngeal location in a 4 year-old boy, diagnosed by fine needle aspiration cytology. The smears revealed scattered large oval to polygonal cells with voluminous, granular cytoplasms. The nuclei were one to two in number and had a prominent nucleolus. Clusters of benign spindle-shaped cells were also present.