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이준희,이상훈,이향선,지승택,정석윤,김재호,배순식,권상모 대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.5
Adipogenic differentiation of mesenchymal stem cells (MSCs) is critical for metabolic homeostasis and nutrient signaling during development. However, limited information is available on the pivotal modulators of adipogenic differentiation of MSCs. Adaptor protein Lnk (Src homology 2B3 [SH2B3]), which belongs to a family of SH2-containing proteins, modulates the bioactivities of different stem cells, including hematopoietic stem cells and endothelial progenitor cells. In this study, we investigated whether an interaction between insulin-like growth factor-1 receptor (IGF-1R) and Lnk regulated IGF-1-induced adipogenic differentiation of MSCs. We found that wild-type MSCs showed greater adipogenic differentiation potential than Lnk–/– MSCs. An ex vivo adipogenic differentiation assay showed that Lnk–/– MSCs had decreased adipogenic differentiation potential compared with wild-type MSCs. Interestingly, we found that Lnk formed a complex with IGF-1R and that IGF-1 induced the dissociation of this complex. In addition, we observed that IGF-1-induced increase in the phosphorylation of Akt and mammalian target of rapamycin was triggered by the dissociation of the IGF-1R–Lnk complex. Expression levels of a pivotal transcription factor peroxisome proliferatoractivated receptor gamma (PPAR-γ) and its adipogenic target genes (LPL and FABP4) significantly decreased in Lnk –/– MSCs. These results suggested that Lnk adaptor protein regulated the adipogenesis of MSCs through the IGF-1/Akt/PPAR-γ pathway.
이준희 고려대학교 민족문화연구원 한국문학연구소 2001 한국문학연구 Vol.- No.2
Currently, the study of Language is moved speaker's utterance to hearer's utterance. This currency is made by the change of understanding about speaker. That is, the studies of production in utterance are progressive to the interpretation in utterance. The speaker in structural linguistics play only on role in judging right or wrong sentence. But the speaker in pragmatics play an important role in the subject of speech-acts. The changes of roles with speaker is changed to linguistics but also the study of korean-the treatment.
李俊熙 경주대학교 관광진흥연구원 1999 관광학논총 Vol.3 No.-
Historical memorials are good for sightseeing since they are situated in most historical cities. These historical monuments. combined with technology and art, not only serve as a tourist attraction but it also offers tourist new information about culture. Kang-youwei memorial which is located in Qingdao of Shang-dong Province was occupied by Kang-youwei. It serve as an important resource in historical modern people with a good historical lesson by reconstruct historical culture of Kang's time. Indeed, all the chinese remember him as one of good models in history for his patriotism and passion toward his country. Many tourists have visited his memorial sites to show their respect to him for ages though it was very old and small. When I visited there in July 1999, the memorial was under construction for maintenance and it was reported that it will be completed by May 2000. It is certain that the tourist will be able to appreciate the essence of modern history of china though this restoration of the memorial.