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이주범,이경선,최근범,정현섭,조현석,최기석,김태곤,김서진,이형석,차미진,송시환,이철규,전계택 한국독성학회 2015 Toxicological Research Vol.31 No.4
TS-DP2 is a recombinant human granulocyte colony stimulating factor (rhG-CSF) manufactured by TS Corporation. We conducted a four-week study of TS-DP2 (test article) in repeated intravenous doses in male and female Sprague-Dawley (SD) rats. Lenograstim was used as a reference article and was administered intravenously at a dose of 1000 μg/kg/day. Rats received TS-DP2 intravenously at doses of 250, 500, and 1000 μg/kg/day once daily for 4 weeks, and evaluated following a 2-week recovery period. Edema in the hind limbs and loss of mean body weight and body weight gain were observed in both the highest dose group of TS-DP2 and the lenograstim group in male rats. Fibro-osseous lesions were observed in the lenograstim group in both sexes, and at all groups of TS-DP2 in males, and at doses of TS-DP2 500 μg/kg/ day and higher in females. The lesion was considered a toxicological change. Therefore, bone is the primary toxicological target of TS-DP2. The lowest observed adverse effect level (LOAEL) in males was 250 μg/kg/day, and no observed adverse effect level (NOAEL) in females was 250 μg/kg/day in this study. In the toxicokinetic study, the serum concentrations of G-CSF were maintained until 8 hr after administration. The systemic exposures (AUC0-24h and C0) were not markedly different between male and female rats, between the administration periods, or between TS-DP2 and lenograstim. In conclusion, TS-DP2 shows toxicological similarity to lenograstim over 4-weeks of repeated doses in rats.
이주범(Jubeom Lee),박형민(Hyungmin Park) 한국가시화정보학회 2016 한국가시화정보학회 학술발표대회 논문집 Vol.2016 No.4
Two-phase cross flow over a bluff body occurs in many thermal and fluid systems. However, only a few studies have been conducted on the fundamental physics on the interaction between the bubbles and a bluff body. In the present study, two-phase flow phenomena around a circular cylinder due to bubble column under a static water condition is experimentally investigated while varying void fraction. It is shown that preferential concentration of bubbles in a cylinder wake changes with mean void fraction.
원형 실린더 주위를 흐르는 기포류 유동의 기포 크기 영향에 대한 실험 연구
이주범(Jubeom Lee),박형민(Hyungmin Park) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Two-phase cross flow over a bluff body occurs in many thermal and power systems such as steam generators, heat exchangers and nuclear reactors. However, only a few studies have been studied on the fundamental effects of the bubbles around the bluff body. Since the rising bubbles generate intensive liquid agitation, the resultant flow structures and bubble accumulation around the solid body are important to understand the pure bubble effect on flow field. In the present study, the two-phase flow phenomena around a smooth circular cylinder induced by the bubble column in a static water is experimentally investigated while varying the mean bubble sizes from 2 to 4 ㎜ and the void fraction by controlling the spargers separately. For the measurements, we basically use the shadowgraph technique and several image processing algorithms. In the wake behind a circular cylinder, the void distribution shows a specific trend similar to the formation of recirculation region for the single-phase flow, which changes with the mean void fraction and the bubble size. We will analyze this in terms of bubble dynamics and bubble-induced flows on a solid body.