소화성궤양에 (消化性潰瘍) 대한 Centella asiatica 정량추출물 (定量抽出物) ( Madecassol ) 의 치료효과

이종철,최규완 ( Jong Chull Rhee,Kyoo Wan Choi ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1

The Purpose of this paper is to evaluate the clinical efficacy of the titrated extract of Centella asiatica (TECA: Madecassol) in patients with peptic ulcer. Nineteen patients with gastric ulcer and thirteen patients with duodenal ulcer were given 60mg a day, P.O. and 20mg, I.M., 3 times a week of TECA and were followed up by gastroscopy at 4, 6, 8, and 10 weeks of treatment. The observed results are as followed: 1) Six (31. 6%) out of 19 cases of gastric ulcers were completely healed off by 4 weeks, 14 (73, 7%) by 6 weeks, and 17 (89. 5%) by 8 weeks of treatment. One case was not healted up to 10 weeks of treatment. 2) Five (38. 5%) out of 13 cases of duodenal ulcers were completely healed off by 4 weeks, 9 (69. 2%) by 6 weeks and 11 (84. 6%) by 8 weeks of treatment. One case was resistant to the treatment up to 10 weeks of observation. 3) There was no untoward side reaction, either subjective or objective, to the administration of the drug.

소화성궤양의 치료에 관한 연구 : 공격인자 억제제와 방어인자 항진제의 합병투여의 효과

박영태,이종철,송인성,최규완 ( Young Tae Bak,Jong Chull Rhee,In Sung Song,Kyoo Wan Choi ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1

The purpose of this study was to evaluate the therapeutic effect of defensive factor promotors in combination with H, receptor antagonist in peptic ulcer treatment. A prospective study was conducted on the open trial basis with consecutive method of medication. Diagnoses of total 58 patients(gastric ulcer: 36, duodenal ulcer: 22) were confirmed by gastroduodenoscopy. The patients were assigned to one of the following 3 treatment groups. Group A: 25 cases, Antacids+Cimetidine+Cetraxate, Group B: 18 cases, Antacids+Cimetidine+Sucralfate, Group C: 15 cases, Antacids Cimetidine. Each patient was followed up at 6 th week of treatment, and the therapeutic effect was evaluated. The results were as follows: Healing rates of gastric ulcers were Group A: 58. 3%, Group B: 50. 0%, Group C: 58. 3% ,,nd Total: 55. 6fc. There was no significant difference of healing rates among the groups. 2) Healing rates of duodenal ulcers were Group A: 92.3%, Group B: lpp 0%, Group C: 100. O>o and Total: 95. 5%. There was no significant difference of healing rates among the groups. But there was significant difference between gastric ulcers and duodenal ulcers. Alove results and those of previous study were compared together, and they revealed that there svas no significant difference of healing rates among the following G therapeutic groups: Antacids Cimetidine, Antacids+Cetraxate, Antacids+Sucralfate, Antacids TECA, Antacids+ Cimetidine+ Cetraxate, anrl Antacids+ Cimetidine+ Sucralfate.

Pirenzepine 의 소화성궤양치료효과에 (消化性潰瘍治療效果) 대한 임상적 (臨床的) 연구

최규완(Kyoo Wan Choi),이종철(Jong Chull Rhee),박영태(Young Tae Park) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.1

N/A The purpose of this study is to assess the clinical therapeutic effectiveness and any possible side reaction of the anti-muscarinic agent, pirenzepine. The drug was given in the dose of 50 mg twice a day to 27 cases of gastric ulcer and 23 cases of duodenal ulcer. Initial diagnosis, and follow-up observations after 4 weeks, 6 weeks and 8 weeks of treatment were made by the upper G- I endoscopy. The results observed are as followings: 1. The male to female ratio of the subjects was about 4: 1 and the most prevalent age group was the fifth decade of the life in both the gastric and duodenal ulcer groups. 2. As for the subjective symptoms, postprandial discomfort, burning sense and hunger pain were experienced in 47 cases (85.5%), 42 cases (76.4%) and 36 cases (65.5%) respectively, and were completely relieved after 4 weeks of treatment in 35 cases (74.5%). 40 cases (95.2%) and 33 cases (91.7%) respectively. 3. The cumulative rates of complete healing of the gastric ulcers (27 cases) were 63.0% (17 cases) after 4 weeks, 74. 10% (20 cases) after G weeks, and 77. 8,o (21 cases) after 8 weeks of treatment, and those of the duodenal ulcers (28 cases) were 71.4% (20 cases) after 4weeks , 78.6% (22 cases) after 6 weeks, and 89.3% (25 cases) after 8 weeks of treatment 4. As for the untoward side effects associated with administration of the drug, diarrhea, dry mouth, flatulence, and constipation were noted in 12,5,3 and 2 cases respectively. However in none of these cases the symptoms were severe enough to discontinue medication. In conclusion pirenzepine appears to be effective and safe for the treatment of patients with peptic ulcer diseases.

소화성궤양 재발예에 관한 내시경학적 연구

최규완 ( Kyoo Wan Choi ),백승운 ( Seung Woon Paik ),이종철 ( Jong Chull Rhee ) 대한내과학회 1984 대한내과학회지 Vol.27 No.4

기능성 소화불량증 환자에서의 Electronic Barostat을 이용한 위 팽창 반응에 관한 연구

이규택(Kyu Taek Lee),손희정(Hee Jung Son),이종균(Jong Kyun Lee),이준혁(Joon Hyeok Lee),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),이종철(Jong Chull Rhee),노재형(Jae Hyung Noh),최성호(S 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2

N/A Background/Aims: A decreased perception threshold of gastric distension has been observed recently in selected patients with functional dyspepsia(FD) in the absence of changes in gastric compliance. The sensations induced by changes in intragastric pressure and volumes have been shown to be independent of gastric emptying times. In Korea, there has been no report about the response to gastric distension using electronic barostat in patients with FD. Thus, we aimed to evaluate whether decreased perception threshold to the gastric distension could be one of the pathogenic factors in FD. Methods: Thirty patients with dysmotility-like FD(9 men and 21 women; age range, 27-57 years) and 20 healthy individuals without gastrointestinal symptorns(10 men and 10 women; age range, 20-54 years) were included in this study after receiving written informed consent. We measured intragastric minimal distending pressure(MDP), gastric compliance, aMominal discomfort level, and gastric emptying rate of solid meal. We used a dual drive barostat (G&J Electronics, Canada) and biad gamma camera(Trionix). MDP was defined as the first pressure level to inflate an intra gastric bag volume > 30mL. And then, symptoms and volume of the intragastric bag, which was inflated by increasing intragastric bag pressur, was measured in 1 mmHg steps every 3 minutes, We compared gastric compliance at a low pressure zone(0-2 mmHg above MDP) and at a high preassre zone(6-8mmHg above MDP), We calculated the mean values( SD) of the parameters, and statistical comparisons were performed using tbe repeated measures ANOVA. Results: The MDP was significantly decreased in FD(3.9>1.8 mmHg) compared to the controls(5.7+ 1.7 mmHg; p<0.001). The gastric compliance(Cw) at a high pressure zone was significantly higher in FD(46.5+30.6 mL/rnmHg) compared to the control(31.3 + 15.3 mL/mmHg; p<0.05). Whereas there was no difference in compliance(C) at the low pressure zone(41.2+25.6 mL/mmHg in FD vs. 43.9+23.1 mL/mmHg in the control). Patients with FD had gastric hypersensitivity to distension(discomfort threshold at 8.3+3.8 mmHg and 392+109 mL in FD vs. 14.S+3.8 mmHg and 558+135 rnL in controls; p<0.001). There were no differences in MDP, compliance, and discomfort level according to gastric emptying times. Conclusions: We conclude that decreased perception threshold to gastric distension could be a pathogenic factor, and also an increased gastric compliance at high pressure zone may play a pathogenic role in FD. (Korean J Gastroenterol 1997;29: 135 - 144)

Open Endoscopic Assessment of the Clinical Therapeutic Effectiveness of Proglumide in Gastric and Doudenal Ulcer in Korea

Rhee, Jong Chull,Choi, Kyoo Wan 최신의학사 1981 最新醫學 Vol.24 No.6

항문경 환자의 바이오피드백 치료 효과에 영향을 미치는 인자 : 단변량 및 다변량 분석

김영호,손희정,김재준,최규완,백승운,최문석,고광철,이풍렬,이종철 대한소화기학회 1999 대한소화기학회지 Vol.34 No.2

Background/Aims: Biofeedback is known as the most effective treatment for patients with anismus, but it is ineffective in some patients. Furthermore, little has been known about factors to predict response to biofeedback. The aim of this study was to evaluate the factors associated with poor response to biofeedback. Methods: Biofeedback was performed for 45 consecutive patients with anismus. Demographics, symptoms, and parameters of anorectal physiologic tests were compared between responders (in whom bowel frequency increased up to three times or more a week after biofeedback) and non-responders (in whom bowel frequency remained less than three times a week). Results: Thirty-one patients (68.9%) responded to biofeedback and fourteen (31.1%) did not. Anal canal length was longer in non-responders than in responders (4.53±0.50 cm vs. 4.08±0.56 cm, p=0.02) and rectal maximum tolerable volume (MTV) was larger in non-responders than in responders (361±87 ml vs. 302±69 ml, p=0.02). On multivariate analysis, ananal length and rectal MTV were the factors that show significant difference between responders and non-responders (p=0.027 and p=0.034, respectively). Conclusions: Our results showed that a long anal canal and increased rectal MTV are associated with poor response to biofeedback for patients with anismus.

`무통성 정상통과 정상배변형` 변비에서 보이는 직장 내 감각기능 저하

김영호,이화영,손희정,김재준,최규완,백승운,고광철,이풍렬,김창섭,이종철 대한소화기학회 1999 대한소화기학회지 Vol.34 No.4

Background/Aims: The functional constipation consists of slow transit, defecatory disorder and the normal transit/normal defecatory constipation. It can be divided into the group with pain (irritable bowel syndrome) and the group without pain. We evaluated the difference in the rectal motor and sensory function between patients with the painless normal transit/normal defecatory constipation (pNT/ND C) and controls. Methods: Rectal barostat was carried out in 13 pNT/ND C (M:F=4:9, mean age 46.6 yrs) and 10 controls (M:F=5:5, mean age 29.1 yrs). The thresholds for the minimal sense, the call to stool and the urgency were checked as sensory parameters. The compliance was expressed by the slope of the pressure-volume curve. The basal tone was measured by the volume of (minimal distending pressure+10) mmHg. Results: The thresholds for the minimal sensory pressure of patients and controls were 16.7±6.1 vs. 6.6±3.3 mmHg. The thresholds for the minimal defecatory pressure were 22.9±7.1 and 15.7±3.7 mmHg and those the urgency pressure were 23.8±7.3 vs. 21.4±5.9 mmHg. These results indicated that the three thresholds were significantly increased in the pNT/ND C than in the controls (p$lt;0.01). However, the compliance and basal tone were not significantly different in both groups. Conclusions: The visceral hyposensitivity may play a pathogenic role in developing painless normal transit/normal defecatory constipation.