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이종걸,윤정민,Chun-Mei Lin,정아영,정기연,이범준,윤영원,남상윤 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1
Neurotoxicity and oxidative injury induced by glutamate cause neuronal degeneration related to various central nervous system diseases. Resveratrol, a polyphenolic compound, is known to have antioxidative and anti-inflammatory effects. The aim of this study was to investigate whether resveratrol has a neuroprotective effect against glutamate-induced toxicity in cultured cortical neurons. After exposure to glutamate for 15 min, cortical neurons originated from ICR mouse fetuses on embryonic days 15-16 were then treated with resveratrol for 24 h in the post-treatment paradigm. Glutamate induced a significant reduction in cell viability, but the cell viability was significantly increased by resveratrol. Glutamate induced ROS generation and apoptotic neuronal death, but resveratrol reduced them. The mRNA expressions in antioxidant enzymes, cytoplasmic glutathione peroxidase, copper/zinc superoxide dismutase (SOD), and manganese SOD, and anti-apoptotic regulator Bcl-xL were decreased by glutamate, but resveratrol significantly increased their mRNA levels. In addition, the mRNA expressions of pro-inflammatory cytokines, interleukin-1β and tumor necosis factor-α, were increased by glutamate insult, but significantly reduced by resveratrol. These findings indicate that resveratrol are neuroprotective against glutamate-induced toxicity, suggesting a useful therapeutic application in the treatment of neurodegenerative disorders.
이종걸,연정민,정기윤,임춘매,정아영,이범준,윤영원,남상윤 사단법인 한국동물생명공학회 2011 한국동물생명공학회지 Vol.26 No.4
Procymidone is a fungicide with anti-androgenic properties widely used to protect fruits from fungal infection,which induces an excessive reactive oxygen species production in male reproductive organs. In this study, to clarify whether procymidone affect the cellular antioxidant system of prostate at onset of puberty, gene expression patterns of the representative antioxidant enzymes such as cytoplasmic glutathione peroxidase (GPx1), phospholipid hydroperoxide GPx (PHGPx), selenoprotein P (SePP), cytoplasmic copper/zinc superoxide dismutase (SOD1), and manganese SOD (SOD2) were investigated in the rat ventral prostates exposed to procymidone using real-time RT-PCR analyses. Seven-week-old Sprague-Dawley rats castrated at 6 weeks old were treated with procymidone (25, 50, or 100 mg/kg per day) orally for 7 consecutive days after testosterone propionate (0.4 mg/kg per day) administration by subcutaneous injection. As compared to normal control animals, GPx1 mRNA expression in prostates significantly increased by the administration with TP and/or procymidone. However, PHGPx and SOD1 mRNA levels significanatly decreased by over 25 mg/kg of procymidone treatment and SePP and SOD2 mRNA levels was significanatly reduced by over 50 mg/kg of procymidone treatment. These findings indicate that procymidone may affect the antioxidant system of prostatic cells in up-regulation mode of GPx1, but in down-regulation modes of PHGPx, SePP, SOD1, and SOD2, suggesting that procymidone may affect differently the cellular antioxidant system of prostate according to the exposure doses
李鍾傑 忠州大學校 1985 한국교통대학교 논문집 Vol.19 No.1
This paper developed systematically the theory of natural number using peanos axiom based on set, and examied the relation of eguality. Introducing the four rules of arithmetic operation on the basis of set theory and examining their properties, this paper constructed a system of natural number. I hope this paper will help do logical thinking in using the natural numbers and grope for desirable teaching method.
李鍾傑 忠州大學校 1995 한국교통대학교 논문집 Vol.30 No.1
This paper developed systematically the theory of Complex number using based on set, and examined the relation of equality. Introducing the four rules of arithmetic operation on the basis of set theory and examining their properties, this paper constructed a system of Complex number. I hope this paper will hope do logical thinking in using the Complex number and grope for desirable teaching method.
李鐘傑 忠州大學校 1997 한국교통대학교 논문집 Vol.32 No.1
This paper developed systematically the theory of Fractional Expression using and based on set, and examined the relation of equality. Introducing the four rules of arithmetic operation on the basis of set theory and examining their properties, this paper constructed a system of Fractional Expression. I hope this paper will help think logically in using the Fractional Expression and grope for desirable teaching method.