지역사회 획득 소아 요로 감염에서 Extended-Spectrum ${\beta}-Lactamase$ 생성

이정원,신지선,서정완,이미애,이승주,Lee Jung-Won,Shin Jee-Sun,Seo Jeong-Wan,Lee Mi-Ae,Lee Seung-Joo 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2

목적: 소아 요로감염은 적절한 항생제 치료가 중요하며 항생제의 선택에는 E. coli에 대한 항생제 감수성이 기준이 된다. Extended-spectrum ${\beta}-lactamase(ESBL)$은 E. coli 등 그람음성균에서 분비되어 광범위 항생제 내성을 초래하는 효소로서 주로 병원 감염에서 발생하여 치료를 어렵게 하는 요인으로 알려져 있다 저자들은 지역사회 획득 소아 요로감염에서도 ESBL(+) E. coli가 분리되었기에 ESBL(+) E. coli 요로감염의 특성을 후향적으로 조사하고자 하였다. 방법: 2001년 3월부터 2003년 2월까지 이대목동병원 소아과에 입원한 지역사회 획득 E. coli 요로감염 소아(288명)를 대상으로 ESBL을 검사하였다. 검사 방법은 미량 액체배지 희석법을 이용한 자동화 기계(Vitek GNS 433 card)에서 ESBL이 의심되는 균주에 한해 National Committee for Clinical Laboratory Standard (NCCLS)의 기준에 따라 ESBL을 확인하였다. ESBL의 결과에 따라 ESBL(+) E. coli 요로감염의 발생률을 조사하였고 임상적 특징, 위험요인, 항생제 내성률 및 치료효과 등을 ESBL(-) E. coli 요로감염과 비교 분석하였다. 결과:지역사회 획득 소아 요로감염에서 ESBL(+) E. coli의 발생률은 10.8%(31명)이였고 93.5%(29/31)가 6개월 미만의 영아에서 발생하였다(P<0.01). 임상소견은 ESBL 양성군과 음성군 사이에 유의한 차이가 없었다. ESBL 밭생의 위험인자로 잘 알려진 항생제 사용력, 입원병력 및 요로계 기형과도 무관하였다. ESBL(+) E. coli의 항생제 내성률은 ESBL(-) E. coli 에 비하여 유의하게 높았다(P<0.05). Ceftriaxone 투여 48시간 후의 멸균률은 ceftriaxone에 대한 높은 내성률에도 불구하고 96.8%(30/31)로 높았다. 그러나 6개월 이내의 재발률이 25.8%(9/31)나 되었고 이는 ESBL 음성군의 재발률 6.6%(17/227)에 비하여 유의하게 높았다(P<0.05). 결론: 지역사회 획득 소아 요로감염에서 6개월 미만의 어린 영아는 ESBL(+) E. coli 발생의 새로운 위험요인이므로 이에 대한 역학적 연구가 요구된다. 소아 요로감염에서 경험적으로 사용하는 항생제의 선택에 대한 변화가 필요할 것으로 생각된다. Purpose: Appropriate antibiotic therapy is important in childhood urinary tract infection and the selection of anibiotics is based on antimicrobial sensitivity of Escherichia coli. Extended-Spectrum ${\beta}-Lactamase(ESBL)$ is an enzyme produced by gram-negative bacilli that has the ability to hydrolyse penicillins, broad-spectrum cephalosporin and monobactam. There have been many reports of outbreaks of hospital infection by ESBL-producing organism. However, community-acquired infection with ESBL-producing organism are rare. This study was performed to retrospectively identify the incidence, characteristics and risk factors of ESBL (+) E. coli in community-acquired childhood UTI. Methods: In 288 children admitted in Ewha Womans University Hospital with E. coli UTI from Mar 2001 to February 2003, ESBL was isolated. ESBL was confirmed by the utilization of an automatized machine(Vitek GNS 433 card) using liquid medium dilution method according to National Committee for Clinical Laboratory Standard. The clinical characteristics, risk factors, antimicrobial resistance and treatment effectiveness were compared with ESBL(-) E. coli UTI. Results: Of 288 E. coli isolates, 31(10.8%) produced ESBL and 93.5%(29/31) occurred in infants younger than 6 month of age(P<0.01). No significant differences were noted in prior antibiotic use, prior admission history and underlying urogenital anomaly. Antimicrobial resistance was significantly higher in ESBL(+) E. coli compared with control patients (P<0.05). Although ceftriaxone showed 100% resistance in ESBL(+) E. coli, bacteriologic sterilization rate after ceftriaxone therapy was higher(96.8%). However, the recurrence rate of febrile UTI within 6 months was higher(25.8%) than control patients(6.6%). Conclusion: Epidemiologic study is required to find out any new risk factors of community-acquired ESBL(+) E. coli UTI and changes in selection of empirical antibiotics should be considered.

일상 속에 존재하는 경이로움으로의 안내

이정원,Lee, Jeong-Won 한국과학기술단체총연합회 2008 과학과 기술 Vol.41 No.4

한의대 교과목으로서 의료윤리에 관한 고찰

이정원,이해웅,Lee, Jeong-Won,Lee, Hai-Woong 대한예방한의학회 2018 대한예방한의학회지 Vol.22 No.2

Objectives : According to the data from the 2016 Yearbook of Traditional Korean Medicine, 10 out of 12 medical schools of Korean medicine are offering medical ethics. Medical ethics has become essential in Korean medicine education, but there has been no agreement on the content of education yet, so initial discussions are necessary with respect to the content and methods of education. Methods : In this study, basic data were collected by searching papers, reports, books, and media articles on medical ethics related to Korean medicine education, and by studying the website of medical schools of Korean medicine nationwide. Based on the collected data, the status of medical ethics lectures were determined and compared with the current state of medical ethics lectures by western medical schools. The contents suitable for medical ethics education at medical schools of Korean medicine were discussed. Results : The topics of the medical ethics include: the basic concepts of medical ethics, the ethics of birth, the ethics associated with genetics, the ethics associated with death, and the ethics regarding doctor-patient interaction, the ethics of medical research, medical rationing ethics, ethics between medical staffs, medical law and ethics, philosophical base of medical ethics, ethics of doctor as professional, and moral personality formation of doctor. The contents of medical ethics in traditional Korean medicine reflected views on the human body and life based on "Huangdi's Internal Classic"and medical ethics from the viewpoints of Buddhism and Confucianism. Conclusions : Medical schools of Korean medicine are medical training institutions, and medical ethics education is essential to become a Korean medicine doctor as professional worker, medical practitioner, and biomedical researcher. There is no fundamental difference in the basic principles of medical ethics in both western and Korean medicine, and there are differences in contents depending on the clinical practice. The contents of medical ethics on clinical practice should be modified for Korean medicine doctors, and traditional Korean medicine ethics would be set up upon that. In the national licensing examination, medical ethics needs to be added as one part so that all the ethical problems related to the clinical situation can be solved.

한의과대학 학생의 직업가치가 전공몰입, 전공만족에 미치는 영향

이정원,김경철,Lee, Jeong Won,Kim, Gyeong Chul 대한예방한의학회 2020 대한예방한의학회지 Vol.24 No.1

Objective : The purpose of this study is to determine the Work value of Korean medicine college students and check how the Work value of college students affects major commitment and major satisfaction. Method : The data for this study were collected through a self-administered survey to 207 subject from students enrolled in the University in B city. Frequency analysis, repeated measures ANOVA, multiple regression analysis were used for the statistical analysis. Results : As a result of analyzing the occupational value of students enrolled in the College of Korean Medicine, the pursuit of professionality and interest was the highest, the pursuit of achievement was the next highest, and the pursuit of diversity and change was the lowest. As a result of the multiple regression analysis, pursuit of achievement and professionality had a positive(+) effect, and pursuit of ease had a negative(-) effect on the major commitment. Also, the pursuit of professionality and interest had a positive(+) effect, and pursuit of ease had negative(-) effect on major satisfaction. Conclusion : In order to increase students' major commitment and satisfaction, it is necessary to make efforts to compose the programs and educational contents that can satisfy these values. In addition, the efforts of universities and professors are needed to help students establish the correct their work value.

가습 입자를 활용한 고효율 난방 시스템 개발

이정원,홍경보,Lee, Jeong-Won,Hong, Kyung-Bo 한국금형공학회 2020 한국금형공학회지 Vol.14 No.4

Products for heating indoors in low temperature and dry winter are largely divided into products using fossil fuels and products using electricity. The fossil fuels can warm the entire space by convection, but there is a high risk of fire and the frequent ventilation due to the increase in carbon monoxide and carbon dioxide. Heaters using electricity are mainly used because they are convenient to use and are cheap. However, these products can not efficiently warm the air because they use radiation energy. In other words, only the front part exposed to the heater is warm, and the rear part has no heating effect at all. Also, because it emits a large amount of light, fatigue of the eyes is very high. Another problem is that when using electric heaters, the room tends to be dry by high heat. Indoor humidity maintenance is a very important factor in the prevention and treatment of respiratory diseases. Especially, it is essential for health care for infants, bronchial organs and people with weak respiratory because humidity is low in winter. In this study, we conducted a study to develop a product that can improve heating efficiency while maintaining proper indoor humidity by combining heat energy and moisture particles. The concept of humidification and heating at the same time, moisture particles generated in the humidifier pass through the heater, include thermal energy, and the moisture particles with thermal energy are diffused into the space by forced convection, thereby warming the entire space. In addition, the heating time is shortened as the feeling temperature is increased with the high relative humidity, and this has the effect that the heating cost in winter is reduced.

개불알풀꽃의 대왕님

이정원,Lee, Jeong-Won 한국조경수협회 1996 造景樹 Vol.30 No.1

생산비 절감을 위한 효율적인 돈사시설

이정원,Lee, Jeong-Won 대한양돈협회 1987 養豚 Vol.9 No.1

중학생과 학부모의 가공식품에 대한 인지도가 식품표시의 이용에 미치는 영향

이정원,김동순,Lee, Jeong-Won,Kim, Dong-Sun 대한영양사협회 2003 대한영양사협회 학술지 Vol.9 No.3

In order to investigate the recognition of processed foods, use of food labeling, and their influencing factors in adolescents, 277(male 125, female 152) middle school students were conveniently selected from Cheonan city, and were surveyed by self-recording questionnaire on June, 2000. Subjects' parents were also surveyed using the similar questionnaire. Food labels of all 222 processed foods collected from stores around schools, were well labeled in most items, but food additives(35.6%) and the origin of major ingredient(27.0) were not well indicated. The recognition score of processed foods was 55.0 out of a full score 100 in students and 68.5 in parents. The scores of students were positively correlated with those of their parents and with father's education years, while negatively correlated with snacking expenses. The rate of reading food labels was significantly different between students(51.3%) and their parents(89.9%). The main purposes of reading food labels, in case of students, were to check expiry date(93.7%), price(70.4%), and how to eat(46.5%) in order. While in parents, those were to check expiry date(95.6%), additives(59.0%), and manufacturer(45.8%). Similarly, the most three important items in food labels were expiry date, price, and quantity to the students, but to the parents they were expiry date, manufacturer, and ingredient. The most significant reason not to confirm food labels was because of small size and complication of labels. The students who did not read food labels had more snacking money and more frequent snacking, and showed lower recognition score of processed food, compared with the students who read food labels. In conclusion, the students did not well recognise processed foods and only a half of them read food labels at purchasing. The recognition score of processed foods, snacking moneys, and snacking frequency may be influencing factors on the reading of food labels in students. The high recognition of processed food of parents may positively affect the students' recognition, but did not affect directly the reading food labels.

압전 박막 응용

이정원,Lee, Jeong-Won 한국전기전자재료학회 2010 전기전자재료 Vol.23 No.9

일개대학 학생의 한의학 브랜드 개성 인식에 대한 기초연구

이정원,Lee, Jeong Won 대한예방한의학회 2016 대한예방한의학회지 Vol.20 No.3

Objectives : The purpose of this study is to determine the Korean medicine brand personality awareness of university students and to determine how the Korean medicine brand personality affects the perceived value. Methods : The data for this study were collected through a self-administered survey to 173 subject from students enrolled in the University in B city. Frequency analysis, factor analysis, t-test, ANOVA, multiple regression analysis were used for the statistical analysis. Results : The result of factor analysis, seven factors were extracted. That was refinement, pleasure, trust, warmhearted, capacity, handsomeness, individuality. Overall, capacity, trust, warmhearted, handsomeness scores of Korean medicine brand personality score was higher than individuality, pleasure, refinement. Especially warmhearted, capacity affects the perceived value. Conclusions : Seven Korean medicine brand personality factors were extracted. Warmhearted, capacity affects the perceived value. It is necessary to develop the Korean medical management strategy and Korean medical policy.