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기니픽심근에서 Na-H 교환기 억제제가 무스카린 수용체 흥분에 의한 세포내 Na활성도 증가에 미치는 영향
이재백,채수완,황룡 의과학연구소 1991 全北醫大論文集 Vol.15 No.2
It has been known that carbachol increases intracullular sodium activity(a_N^i_a) and twich force. However the mechanism of a_N^i_a increase is not clear. The a_N^i_a twich force and membrane potenital guinea pig papillary muscle were measured simultaneously during exposure to carbachol(3X10exp(-4)M) and subsquent washout in the absence and presence of selective NaH exchange inhibitor, hexamethylene amiloride, or low extracellular pH(6.6) condition. The results are : 1. Hexamethylene amiloride(30㎛) inhibited NH_4Cl(10mM) induced transient decrease of a_N^i_a following marked increase of a_N^i_a which indicates that hexamethylene amiloride is a Na-H exchange inhibitor of heart muscle. 2. Carbachol induced a_N^i_a increase in quiescent and beating ventricular muscle were inhibited by hexamethylene amiloride. 3. Low extracelluar pH(6.6) inhibited carbachol indeced a_N^i_a increase in quiescent and beating ventricular muscle. 4. Low extracellular pH increased twitch force, increased action potential duration and intracellular sodium activity, and depolarized diastolic membrance potental. From above results, it is suggested that carbachol increase a_N^i_a via Na-H exchange and Na-H exchange system of ventricular muscle which is different form the action of muscarinic receptor stimulation in Purkinje fibers.
대장 및 직장수술의 전처치에 사용된 Taurolin의 임상적 효과
이재백,황용 의과학연구소 1989 全北醫大論文集 Vol.13 No.1
Operations of the colon and the rectum are often associated with postoperative sepsis because of abundant reservoir of pathogenic bacteria in the colon and rectum. One of the most important parts of the preoperative preparation is the mechanical cleansing of the target bowel to reduce the postoperative infectious incidence. Mechanical preparation alone appeared to reduce the amount of solid feces in the colon, but had a minor influence on the number of fecal bacteria at the time of operation. So we applied the another conventional preparation method that consists of large quantities of saline infusion through a rectal tube with the use of additional taurolin, broad spectrum bactericide and anti-endotoxin, in the termination of the bowel irrigation. Then we compared the results of the method to those of classical and whole gut irrigation methods. The results were as followings; 1) 51 male and 28 female, with a mean age of 50 (18-70) years were examined in this study. 2) Rectosigmoid colon cancer(43.1% ) was most common in the postoperative diagnosis, and other benign dseases and right colon cancer were followed. 3) Abdominoperineal resection (25.3%) was most frequently preformed in operative procedures, and right hemicolectomy(22.8%) followed. 4) In the additional taurolin enema group, organisms were cultured less frequently after taurolin retention enema than after pure saline enema. 5) Contaminated postoperative complications were developed less frequently in the taurolin enema group than in whole gut irrigation and classical irrigation group, and the incidence of those complications revealed 15.0%, 30.0% and 67.0% respectively. 6) The mean duration of hospitalization was 22 days, 27 days, and 24 days in order of the taurolin enema group, whole gut irrigation group and classical irrigation group respectively. (Key words : taurolin retention enema, classical colon irrigation, whole gut irrigation)
이재백,이승렬,강남부 의과학연구소 1989 全北醫大論文集 Vol.13 No.1
A clinical study of sagacin used for the prevention and treatment of many infections in surgical fields was performed in 30 patients admitted into the Department of General Surgery of Chonbuk National university Hospital. The results were following. 1) Of 17 prophylactic uses in which sagacin was used either or in combination with other antibiotics, all recovered from the disease state without any postoperative complication, and the efficacy of sagacin revealed 100% in the prophylactic use. 2) Of the 11 prophylactic cases in which sagacin was used alone, any postoperative surgical infection was not observed. 3) Of 13 therapeutic uses in which sagacin was used in combination with other antibiotics, 11 cases revealed excellent clinical response. 4) Drug toxicities such as hepatotoxicity, nephrotoxicity and ototoxicity were not developed in sagacin treated group and sagacin could be administered intramusculary for two or more weeks without any side reactions.