고지 훈련이 알파인 스키 선수들의 VO_(2)max, 무산소성 역치, 혈액성분 및 면역물질에 미치는 효과

이장규,김진해 한국운동과학회 2003 운동과학 Vol.12 No.3

이장규, 김진해. 고지훈련이 알파인 스키 선수들의 ??O_(2)max, 무산소성 역치, 혈액성분 및 면역물질에 미치는 효과. 운동과학, 제12권 제3호, 357-366, 2003. 이 연구의 목적은 6주간의 고지훈련과 해수면에서의 훈련으로 나타나는 변화기전을 구명하고 그 결과를 알파인 스키 선수들의 경기력 향상을 위한 기초자료로 활용하는데 목적이 있다. 실험대상자는 고지훈련 집단(n=7)은 주당 6일, 일일 5시간씩 트레이닝을 실시하였으며, 해수면훈련 집단(n=7)은 네가지의 트레이닝을 주 5회 반복 트레이닝하였다. 6주간의 트레이닝 결과 최대산소섭취량과 무산소성 역치는 고지훈련 전ㆍ후에 유의하게 증가(p<.01)되었으며, 훈련 후 고지훈련 집단이 해수면훈련 집단보다 두 변인 모두 유의하게 높은 것으로 나타났다(p<.01). 적혈구와 헤모글로빈의 농도는 고지훈련 집단에서 훈련 전ㆍ후에 증가하는 경향을 보였으나 유의차는 없었으며, 훈련 후 고지훈련 집단의 헤모글로빈 농도가 해수면훈련 집단보다 유의하게 높은 것으로 나타났다(p<.01). 또한 젖산의 농도는 고지훈련 전ㆍ후 유의하게 감소(p<.01)되었으며, T-세포는 고지훈련 전ㆍ후에 유의하게 감소(p<.01)되었고, NK-세포는 두 집단 모두 유의하게 증가(p<.05)되었다. 이상의 결과를 종합해보면, 알파인 스키선수들의 경기력 향상에 필요한 유ㆍ무산소성 요인을 증가시킴에 있어서 고지훈련이 해수면에서의 훈련보다 긍정적인 결과를 가져온다는 것을 알 수 있다. Lee, J.K., Kim, J.H. The Effects of Altitude Training on ??O_(2)max, Anaerobic Threshold, Blood Components and Immune Substrates in Elite Alpine Skiers. Exercise Science, 12(3): 357-366, 2003. The purpose of this study was to determine effect of altitude training on ??O_(2)max, anaerobic threshold(AT), blood components, immune substrates. 7 male subject classified as the altitude training (Al-T) group trained at the altitude of 2,700-3,500m in Tignes, France for 6weeks. 7 male subjects classified as the sea level training(SI-T) group trained in domestic. They were top level college alpine skiers. The results of this study were as following: First, ??O_(2)max and AT significantly increased after training in both group(p<.01), whereas blood lactate level significantly decreased in Al-T after training(p<.01). Second, RBC and Hb were slightly increase in both group(12.1%, 12%, respectively), but no significant. Third, T-cell significantly decreased in Al-T(p<.01), whereas NK cell significantly increased in both group(p<.05) after training. In conclusion, altitude and sea level training elevates competitive ability in alpine skiers, such as ??O_(2)max, AT, blood components and immune substrates, but altitude training significant effect better than sea level training.

쥐 골격근의 산화효소 활성, PPAR 단백질 및 지질대사 관련 mRNA 발현에 미치는 트레이닝의 효과

이장규,이종삼,박수연,조인호,박인숙,김창근 한국운동과학회 2004 운동과학 Vol.13 No.2

이장규, 이종삼, 박수연, 조인호, 박인숙, 김창근. 쥐 골격근의 산화요소 활성, PPAR 단백질 및 지질대사 관련 mRNA 발현에 미치는 트레이닝의 효과. 운동과학, 제13권 제2호, I77-188, 2004. 이 연구에서는 지방대사에 밀접한 관련을 맺는 효소 활성도와 단백질 및 유전자 발현에 미치는 훈련의 효과를 밝히기 위해 16마리의 암컷 Sprague-Dawley를 이용하였다. 실험 동물은 통제집단(n=8)과 트레이닝집단(n=8)으로 무선 배정되었으며 트레이닝은 28mㆍmin^(-1)(75-80% VO₂max에 해당)의 속도로 1000m를 완주하도록 하였다. 8주간 (4timesㆍsession^(-1))의 실험 처치 후 모든 동물의 오른쪽 장단지로부터 가자미근을 적출해 분석에 사용하였다. 실험 요인들의 분석을 위해 Spectrophotometer (산화 효소의 활성도), Western blot(PPAR 단백질 발현), 및 RT-PCR(각종 mRNA발현) 기법을 사용하였다. 실험처치 후 두 실험집단간 체중은 유의한 차를 보이지 않았으며 PPAR 단백철 발현량에서도 차이를 보이지 않아 훈련이 이들 변인에 미치는 효과가 크지 않았음을 보였다. 효소활성도에서는 CS에서 유의한 차를 보이지 않았으나 β-HAD의 활성도에서는 유의한 훈련의 효과가 냐타났다(p<0.05). 효소의 활성도와는 달리, β-HAD mRNA 발현은 트레이닝 집단에서 유의한 감소를 보였다. 그 밖의 지방 산화에 관여하는 것으로 보이는 다양한 요인들 (CPT-1, PDK4, FAT/CD36 그리고 UCP3)에 대한 mRNA의 발현량에는 유의한 훈련의 효과를 관찰할 수 없었다. 결론적으로, 8주간의 훈련은 지방 산화에 관여하는 효소의 활성도에는 영향을 미치지만 단백질 및 유전자 발현에는 그 효과가 미미하다고 하겠다. 다양한 훈련의 기간과 감도에 따른 후속 연구들을 텅해 세포내 지방 산화 과정이 과학적으로 밝혀져야 할 것이다. Lee, J. K., Lee, J. S., Park S. Y., Cho, I. H., Park, I. S., Kim,C. K. Effects of long term regular exercise on oxidative enzyme activities, and peroxisome proliferators activated receptor protein and mRNA expressions that are involved in liquid oxidative process in rat soleus muscles. Exercise Science, 13(2): 177-188, 2004. We investigated whether long term regular training exerts any significant roles in regulatory genes (i.e., fatty acid trans-locase [FAT/CD36] mRNA, carnitine palmitoyl transferase[CPT-l] mRNA, β-hydroxyacyl CoA dehydrogenase [β-HAD] mRNA, pyruvate dehydrogenase kinase-4 [PDK4] mRNA, mitochondrial uncoupling protein-3 [UCP3] mRNA and proteins (peroxisome proliferators activated receptor [PPAR]α and γ) expression, and enzyme (citrate synthase [CS] and [β-HAD]) activities that closely involved in lipid uptake and oxidation in skeletal muscle cells. Sixteen female Sprague-Dawley rats were used, and divided into two experimental conditions: either untrained (n=8) or trained (n=8). Whlie rats in untrained group performed no training, animals in trained group undertook 8wk of regular exercise (4 timesㆍwk^(-1), 1000mㆍsession^(-1)) on the treadmill. Although training tended to upregulate the expression of all genes important for lipid oxidation, β -HAD mRNA significantly decreased (p<O.05). Unlike our hypothesis, there was no exercise training effect on PPAR α and γ protein abundance (p>0.05). Similar to PPAR protein expressions, oxidative enzymes did not also show any significant alteration following 8wk regular training program. It was suggested that regular aerobic exercise does not affect on PPAR α and γ as well as gene expressions in oxidative skeletal muscle fibers. Studies examining of this molecular response including the major transcriptional regulators, and gene expressions following various training regimens (i.e., training duration and intensities) are required.

K-최근접 이웃 분류기를 이용한 원공결함을 갖는 유한 폭 판재의 음향방출 음원특성과 파괴거동에 관한 연구

이장규,우창기,오진수 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The objective of this study is to evaluate an acoustic emission (AE) source characterization and fracture behavior of the SM45C steel by using k-nearest neighbor (KNN) classifier. In previous research continuously, simple tension and AE tests were conducted against the 5 kind of circular hole defect coupons. Also, for this, we used K-means clustering as an unsupervised learning method for obtained multivariate AE main data sets, such as AE counts, energy, amplitude, risetime, duration and counts to peak. And we applied KNN classifier as a supervised learning pattern recognition algorithm for obtained multivariate AE working data sets. Through the classified results, i.e., determinant criterion (Wilk) and heuristic criteria (Rij & Tou), of the effectiveness of the proposed method is discussed.

화기제어를 위한 선체운동 추정

이장규,고명삼,이기표,지규인,정학영,서창진,공인영 서울대학교 공과대학 생산기술연구소 1984 生産技術硏究所報告 Vol.7 No.1

음향방출법에 의한 SM 490A 강의 복합용접성 평가 (3)

이장규,인승현,우창기,박성완,김봉각 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

The object of this study is to investigate the effect of compounded welding by using acoustic emission (AE) signals for weld heat affected zone (HAZ) in tensile testing. This study was carried out a SM 490A high tension steel for electronic shielded metal arc welding (SMAW), CO₂ gas arc welding and TIG welding. And correspondingly, the root openings are 3, 4 and 2.8㎜. Data displays are based on the measured parameters of the AE signals, along with environmental variables such as time and load. These history plots give us useful and powerful information to analyze the results of material evaluation testing.

음향방출 신호분류에 의한 SM45C 시효처리재의 인장변형 해석

이장규,우창기,김용배 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

This study investigates tensile deformation of the stress aging heat-treated SM45C steel which are aging temperature at 250, 300℃, aging time at 1,3 hours, and applied load at 300, 400N conditions by using acoustic emission (AE). A signal processing technology used to evaluate an AE source characterization by 2 AE measurement systems, i.e., DiSP & PCI-2 AE hardware and AEwin™ software. In this study, most suitable aging condition appeared at 250℃, 3 hours and 300N. On the other hand, in case of 250℃, 3 hours, 400N and 300℃, 3 hours, 400N conditions, yield load decreased than other conditions according to the over-aging phenomena. Especially, In case of 300℃, 3 hours and 400N condition appeared AE energy in elastic limit fairly high than non-heat treatment specimen.

형광 [카메라] 상에 의한 정상간의 전면형태에 관한 연구 (예보)

이장규,이진오,김종설,장고창,박종인 대한핵의학회 1975 핵의학 분자영상 Vol.9 No.1

교질형방사성금과 dynacamera를 이용하여 정상성인남자의 간전면상을 얻고 이 중 250예에 대하여 새로운 분류기준으로써 총 9가지 종류로 간전면을 형태적으로 분류하여 다음과 같은 결론을 얻었다. 1) 제 5형(2-2)이 47.2% 차지하였으며, 다음이 제 2형(1-2)과 제 6형(2-3)이 각각 16%와 15.6%를 차지하고 제 3형(1-3)이 0.8%로 가장 적었다. 2) 비만이 차지하는 율은 제 1형(1-1), 제 4형(2-1) 및 제 8형(3-2)에서 높았다. 3) 현저한 cardiac impression은 제 7형(3-1), 제 8형(3-2), 제 4형(2-1)순으로 많았고 사각양좌엽은 제6형(2-3), 제 9형(3-3), 제 2(1-2)순으로 많았고, 미 양좌엽은 제 7형(3-1), 제 8형(3-2), 제 5형(2-2)순으로 많았다. $quot; A knowledge of the wide ranges in shape of liver is important in the interpretation of hepatic scintigraphy as some variants may be easily confused with pathological abnormalities. In this study, the variations in shape in 250 cases of normal liver obtained by scintiphoto were categorized into 9 types by means of the arbitrary standard for classification. 1) Among 250 normal cases, type 5 was 118(47.2%) with the highest prevalence and type 3 was 2(0.8%) with the lowest. 2) A higher incidence of obesity was noted in type 1, type 4 and type 8. That of ideal weight was noted in type 2, type 5 type 6 and type 9. 3) A high ratio of cardiac impression in scintiphoto was noted in type 4, type 7 and type 8. That of square left lobe was noted in type 2, type 6 and type 9. Finally that of tailed left lobe was in type 4, type 7 and type 8.

Rb 을 이용한 국소 혈류량 측정편법

이장규,고주환,성호경,문광남 대한핵의학회 1971 핵의학 분자영상 Vol.5 No.2

A simplified method for the local blood flow determination by means of 86Rb was developed in rats and rabbits. (86)^Rb in the form of chloride mixed with physiological saline was intravenously injected. The doses were 10μCi for rats and 100μCi for rabbits, which were injected in less than 5 seconds. The rats were sacrificed after 30 seconds, and the rabbits at the intervals of 10, 20, 40 and 60 seconds, by decapitation or rapid intravenous injection of 3 to 5ml of saturated KCL After bleeding, the organ and tissue samples, e.g. lungs, renal cortex, jejunum and skeletal muscIe were quickly removed. The (86)^Rb uptake in 1 gram of the organs and tissues were measured. On the basis of uptake value, administered dose and body weight, the local blood flow was calculated. Following were the results : 1.The uptake values of 86Rb in the above organs and tissues of rats were different from other previous reports, in which the large rats were used. It appears, therefore, that the cerrection on the basis of body weight is nessary. 2. The uptakes of 86Rb in the above organs and tissues of rabbits remained rather stationary within 20 to 40 seconds. 3. The local blood flow in the above organs and tissues were calculated from 86Rb uptake in per cent dose per I gram tissue for 200 gram body weight. The formula could be applied not only to the rabbits but to the rats. 4. The present method could be applied to tbe comparison of the local blood flow between the various organs and tissues of the control and experimental animals.

판재 최적절단 시스템에 관한 연구

이장규,이선곤,조대희,김봉각 대한안전경영과학회 2008 대한안전경영과학회 학술대회논문집 Vol.2008 No.1

음향방출법에 의한 SM45C 응력시효 처리재의 인장특성 평가

이장규,박복남 대한안전경영과학회 2009 대한안전경영과학회 학술대회논문집 Vol.2009 No.1