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대장 직장암의 안드로젠 수용체와 Transformining growth factor-ß의 조사 및 병리 임상학적 연구
김성록,이용준,박경미 인제대학교 1996 仁濟醫學 Vol.17 No.2
진행성 대장 직장암은 세포독성 항암제가 주 치료법이며, 만족스럽지가 못하다. 이에 저자들은 인체 내 조절 인자를 통한 치료 가능성을 추구하고자 먼저 그 암조직에서의 안드로젠 수용체와 Transforming growth factor-β의 존재 여부를 확인하였고, 임상적인 의미가 조사되었다. Objectives : The prognosis of the advanced colorectal cancer is poor and effect of the conventional chemotherapy has not been satisfactory. This study is to explore the possibility of hormonal therapy or cytokine therapy by assaying hormone receptor and cytokine (androgen receptor and TGF-β), and their correlation with clinicopathologic parameters. Methods: Androgen receptor and TGF- β were assayed by immunohistochemical(IHS) staining. The samples were prepared from surgical resection or biopsy. The correlations between the IHS positivity and clinical features or tumor differentiation were assessed. Results:1 The androgen receptor(AR) was negative in all 20 pt and TGF-β positive in 10(50%); 6 in 11 progesterone receptor positive patient(45%) and 4 in PR negative patient(36%). There was no significant association between the PR and TGF-β positivities. 2. There was no significant correlation between TGF- β positivity and the age, sex, tumorstage or CEA positivity at the time of diagnosis. 3. The histologic and nuclear differentiation(well, moderately and poorly differentiated) were not significantly different according to the status of the TGF- β positivity. Conclusions: This study first identified the TGF- β in colorectal cancer by immunohistological method in Korea. The androgen receptor was not positive. More study is needed to establish the role of the cytokine and hormone receptors in the pathogenesis and treatment of colorectal cancer.