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이경숙,이옥준,이승영,최미영,Kyoungsook Lee,MD,Ok Jun Lee,MD,Seung Young Lee,MD,Mi Young Choi,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5
Purpose: Four patients who presented with an upper lid mass were diagnosed with pilomatricoma after excisional biopsy. We report the cases to improve the differential diagnoses of upper lid masses through investigation of the clinical manifestations and radiological findings of pilomatricoma. Case summary: Three females and one male with ages of six, seven, eight and 46 years, respectively, each presented with a slowly growing and painless upper lid mass of a three-month duration. In the six-year-old patient who had a history of trauma related to the mass, the mass was fixed to the skin, although the masses were movable in the other patients. Upon computed tomography (CT), well-circumscribed, enhancing nodules were found. Excisional biopsy was performed for definite diagnosis and treatment. All completely excised masses were hard and encapsulated with a thin membrane. The sizes of the masses were 12 mm, 10 mm, 10 mm, and 7 mm. Histopathologic examination with hematoxylin-eosin staining confirmed the masses to be pilomatricoma. There was no evidence of recurrence at 16, 2, 19, and 21 months after mass excision. Conclusions: In patients presenting with a painless upper lid mass, pilomatricoma should be considered in the differential diagnosis. J Korean Ophthalmol Soc 2010;51(5):758-763
인플루엔자 감염 후 말초 신경병증으로 발현한 결절성 다발성 동맥염 1예
이동화 ( Dong Hwa Lee ),한정호 ( Jung Ho Han ),김미경 ( Mi Kyoung Kim ),이옥준 ( Ok Jun Lee ),강귀영 ( Kwi Young Kang ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.3
Polyarteritis nodosa (PAN) is a necrotizing vasculitis of the medium-sized arteries. The symptoms and signs of PAN include purpuric skin lesions, mononeuritis multiplex, symptoms of mesenteric ischemia, and renal involvement. We report the first case of PAN manifesting as a neuropathy after influenza infection in Korea. A 68-year-old woman had fever, myalgia, hyperesthesia of both hand and foot, and lower extremity weakness. EMG findings showed severe sensorimotor polyneuropathy, such as multiple mononeuritis. A sural nerve biopsy showed vasculitis and Influenza A (H1N1) were positive. Our patient was treated by glucocorticoid and oral cyclophosphamide, thereafter, symptoms and signs improved. No recurrence has been observed for five months.
최경석 ( Kyung Suck Cheoi ),이원익 ( Won Yik Lee ),음영욱 ( Young Ook Eum ),김희성 ( Hee Sung Kim ),이옥준 ( Ok Jun Lee ),이기형 ( Ki Hyeong Lee ),김승택 ( Seung Taik Kim ) 대한내과학회 2006 대한내과학회지 Vol.71 No.5
유방암의 위전이는 폐, 골, 림프절, 골 전이보다 그 빈도가 매우 드물다. 본 증례는 4년 전 유방암을 앓은 과거 병력을 가진 56세 여자가 상복부 불편감으로 내원하여 상부위장관 내시경과 조직학적상 원발 위암이 아닌 유방암의 위전이가 확인되어 보고하는 바이다. Metastatic cancer from breast cancer is not uncommon and it often involves multiple organs. Gastric metastasis from breast cancer is much rarer than lung, bone and lymph node metastasis. Most of the symptoms are nonspecific, so it is not easy to differentiate primary gastric cancer from gastric metastasis from the breast. In particular, gastric and breast cancers are the two most common cancers among Korean women, so efforts should be made to distinguish primary gastric cancer from gastric metastasis because treatment and prognosis are very different between two. A few cases have been reported in Korea concerning gastric metastasis from breast cancer. We report here a case of gastric metastasis from infiltrating duct carcinoma of the breast.(Korean J Med 71:567-572, 2006)
소포종양이 의심되는 갑상선 결절에서 초음파 검사 소견의 재검토가 진단적 갑상선 절제를 줄일 수 있는가?
최한림(Han-Lim Choi),김동주(Dong-Ju Kim),선우영(Woo-Young Sun),윤효영(Hyo-Young Yun),장이찬(Lee-Chan Jang),최재운(Jae-Woon Choi),이승영(Sung-Young Lee),이옥준(Ok-Jun Lee),박진우(Jin-Woo Park) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.2
Purpose: Follicular neoplasms (FNs) such as follicular adenoma and carcinoma (FTC), nodular hyperplasia (NH) and follicular variant of papillary carcinoma (FVPC) share cytological features. In the present study, we investigate whether review of sonographic findings in patients with thyroid nodules suspicious of FN spares diagnostic thyroidectomies (DTs) by excluding benign diseases such as NH or not. Methods: From June 1999 to May 2007, DTs were performed on 98 patients who had nodules suspicious of FN. High resolution sonographic findings are available for 53 patients. According to the final histologic diagnosis: Group Ⅰ (23 patients) consisted of 20 FNs (11 FTCs), 1 Hurthle cell adenoma, 2 FVPC; Group Ⅱ (30 patients) consisted of all others (23 NHs, 4 Hashimoto’s thyroiditis, 3 papillary carcinomas (PTCs). Sonographic features were compared between the two groups. Results: Three differential sonographic findings (DSF) i.e. irregular margin, absence of peripheral halo or marked inhomogeniety were identified more often in Group Ⅱ than Group Ⅰ (P<0.05). If we spared DTs for patients who have at least one DSF, 18 patients (34.0%) would have been selected for clinical follow-up whose final diagnoses were 14 NHs and 4 PTCs (including 1 FVPC). Sparing DTs by DSFs shows sensitivity, 56.7%; specificity, 95.7%; positive predictive value, 94.4%; negative predictive value, 62.9%; and accuracy, 73.6%, respectively. Conclusion: In patients with thyroid nodules suspicious of FN, sonographic findings such as irregular margin, absence of peripheral halo or marked inhomogeneity might spare DTs with the help of other diagnostic modalities such as cytogenetic or immunohistochemical studies.
갑상선질환에서 Sonic Hedgehog 단백질 발현의 임상적 의의
유근수,이옥준<SUP>1<,SUP>,김원재<SUP>2<,SUP>,박성수,김동주,박진우,최재운,장이찬,OrloH,Clark<SUP>3<,SUP>,Kuhn-Soo Ryu,M,D,Ok-Jun Lee,M,D,<SUP>1<,SUP>,Wun-Jae Kim,M,D,<SUP>2<,SUP>,Sung Su Park,M,D,Dong-Ju Kim,M,D,Jin- Woo Park 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.4
Purpose: The Hedgehog (Hh) signaling pathway is important in embryonic development including cell differentiation and proliferation. Recently, activation of this pathway has been implicated in several forms of solid cancers. We investigated sonic hedgehog (Shh) protein expression and its relation to differentiation and clinicopathologic characteristics in thyroid cancer cell lines and tissues. Methods: We used five thyroid cancer cell lines: TPC-1, FTC-133, FTC-236, FTC-238, and XTC-1. We made tissue microarray slides using 80 thyroid surgical specimen: 40 benign and 40 malignant lesions. Immunohistochemical staining was performed using anti-Shh antibody. mRNA expression of NIS, thyroglobulin, and CD97 were evaluated by RT-PCR. Cyclopamine was used as a Shh signal inhibitor. Results: Shh expression was more prominent in TPC-1, FTC-133, and XTC-1 cell lines than the others. Cyclopamine downregulated CD97 and upregulated thyroglobulin mRNA expression, but did not induce mRNA expression of NIS. Thyroid tissues showed varied expression of Shh in both benign and malignant diseases. Shh expression was detected in 38 of 50 (76%) normal, in 18 of 25 (72%) non-neoplastic benign, in nine of 15 (60%) benign tumors, and in 31 of 40 (77%) malignant tumors. Shh over-expression was significantly less frequent in papillary thyroid carcinomas than in normal or benign thyroid tissues. In addition, Shh protein expression did not relate to clinicopathologic characteristics in papillary thyroid carcinomas. Conclusion: Thyroid tissues and cell lines vary in expression of Shh. Cyclopamine can induce redifferentiation in thyroid cancer cell lines. Shh protein expression, however, is unrelated to clinicopathologic characteristics in papillary thyroid carcinomas. (Korean J Endocrine Surg 2011;11:234-241)
서정훈,이성준,이옥준,최미영,Jeong Hun Seo,MD,Seong Jun Lee,MD,Ok Jun Lee,MD,Mi Young Choi,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.4
Purpose: To investigate the effects of sutureless faden operation to eliminate suture-related perioperative risks in a rabbit model. Methods: Twenty-eighty superior recti muscles of 14 rabbits were subjected to faden operation, at a distance of 6 mm from the insertion of the muscle. They were divided into four groups of 7 muscles each: group A, Beriplast-P ; group B, BardⓇ mesh (12×2 mm); group C, SurgiproⓇ mesh (6×2 mm); group D, SurgiproⓇ mesh (6×6 mm). Rabbits were sacrificed and the eyes were enucleated. The operative field was examined upon dissection, 4 weeks after the surgery. Histopathologic sections were examined for the degree (grade 0 to 4) of inflammation, fibrosis, atrophy and/or degeneration of muscle fiber. Results: Grossly, there was a mild adhesion at the myopexy site in group A, while there was greater adhesion at the myopexy site in groups B, C and D. Group B produced a pronounced adhesion, and the mesh firmly adhered to the sclera as well as to adjacent tissue. Upon histologic examination, group A showed a mild inflammatory reaction and fibrosis, whereas groups B and D showed a moderate inflammatory reaction and fibrosis. The degree of fibrosis in group D was more severe than that in group A (p<0.008), and there was no statistical significance among the other groups (p>0.05). There was atrophy and degeneration in the muscle fiber in all groups, with the exception of group D. Conclusions: In the rabbit model, 6×6 mm sized SurgiproⓇ mesh may be the best material in sutureless faden operation. J Korean Ophthalmol Soc 2009;50(4):603-611