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Diacylglycerol Acyltransferase에 대한 생약자원의 저해활성 검색
이승웅,고정숙,권오억,이상명,김영호,노문철,김영국,이현선,Lee, Seung-Woong,Ko, Jung-Suk,Kwon, Oh-Eok,Lee, Sang-Myung,Kim, Young-Ho,Rho, Mun-Chual,Kim, Young-Kook,Lee, Hyun-Sun 한국생약학회 2001 생약학회지 Vol.32 No.3
The inhibitory effects of methanol extracts of 135 medicinal herbs on diacylglycerol acyltransferase (DGAT) activity were investigated. DGAT was partially purified from rat liver. Eleven kinds of methanol extracts of medicinal herbs including Evodiae Fructus showed a mild inhibitory effect with the concentration of $125\;{\mu}g/ml$ (above 40% inhibition). Six kinds of methanol extracts including Ephedrae Herba exhibited a weak inhibition. Among them, three kinds of butanol extracts (Sophorae Radix, Arecae Semen, Caesalpiniae Lignum) and the chloroform extracts of Evodiae Fructus showed significant inhibitory activities (above 60% inhibition) at the same concentration.
박선경(Seon Gyeong Bak),임형진(Hyung Jin Lim),원영선(Yeong-Seon Won),박은재(Eun Jae Park),오제훈(Je Hun Oh),김지은(Ji Eun Kim),이민지(Min Jee Lee),이소영(Soyoung Lee),이승웅(Seung Woong Lee),이승재(Seung Jae Lee),노문철(Mun Chual Rho 한국축산식품학회 2023 Food and Life Vol.2023 No.1
The skin is the largest organ that blocks invasion to the outside. Due to external stimuli, the skin barrier collapses and immune function abnormalities occur. This leads to skin diseases such as atopic dermatitis and psoriasis. Through this study, we attempted to develop a natural material that can be used for various dermatitis diseases. In this study, the gene expression of skin barrier-related proteins was confirmed using tumor necrosis factor-α/interferon-γ-stimulated HaCaT cells through real-time PCR. As a result, it was confirmed that the gene expression of skin barrier-related proteins and ceramide-related proteins was improved by the ABE-M. In this study, it was confirmed that the gene expression of filaggrin, involucrin, and loricrin, which are skin barrier-related proteins, was improved by ABE-M, and it was confirmed that the gene expression of the tight junction-related proteins, occludin and zonula occludens proteins-1, was also increased. As such, it is expected that ABE-M can be used as a material for skin inflammation such as atopic dermatitis.
호장근의 쿠마린에 의한 RAW 264.7 세포주의 nitric oxide 생성 저해활성
노태철,최희철,이승웅,김영호,노문철,김영국,이현선,Rho, Tae-Cheol,Choi, Hee-Cheol,Lee, Seung-Woong,Kim, Young-Ho,Rho, Mun-Chual,Kim, Young-Kook,Lee, Hyun-Sun 한국생약학회 2001 생약학회지 Vol.32 No.3
During the screening for inhibitors of nitric oxide production in LPS-activated macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of the root of Polygonum cuspidatum. They were identified as decursin (1) and decursinol angelate (2) on the basis of spectroscopic methods. The $IC_{50}$ values of these compounds on NO production were $0.76\;{\mu}M$ (1) and $2.6\;{\mu}M$ (2), respectively. However, the iNOS activity was not inhibited by treatment with these compounds. Their inhibitory effect on NO production seems to result from the suppression of iNOS induction through the suppression of NF-kB activity.
UV-B LED 조사를 통한 각질세포의 비타민 D3 (1,25(OH)2D3) 생성 연구
김인태(In-Tae Kim),조미령(Meeryoung Cho),김유신(Yu-Sin Kim),이승웅(Seung-Woong Lee) 한국조명·전기설비학회 2021 조명·전기설비학회논문지 Vol.35 No.8
Vitamin D has been shown to be associated with cancer of the musculoskeletal system, cardiovascular disease, diabetes, rickets, and etc. In case of vitamin D deficiency, depression, seasonal affective disorder, obesity, and sleep disorder occur. Therefore, in order to alleviate the vitamin D deficiency of modern people who have little outdoor activity, we intend to develop a UV-B LED task lighting system capable of synthesizing vitamin D indoors. In this paper, as a basic study to develop a UV-B LED task lighting system for vitamin D production, an experiment was conducted to verify the vitamin D production effect by UV-B LED lighting. In some test conditions, it was confirmed that vitamin D was significantly increased, but cell death occurred. In the case of non-cell death group, vitamin D increased, but no significant difference was found.
젤라틴 분해력이 있는 Bacillus균의 고추 고구마뿌리혹선충에 미치는 영향
김진한(Jin Han Kim),박찬선(Chan Sun Park),김영호(Young-Ho Kim),김유리(Yu Ri Kim),이승웅(Seung Woong Lee),노문철(Mun Chual Rho) 한국농약과학회 2016 농약과학회지 Vol.20 No.4
This study investigated the decomposing activities on gelatin and egg sac of root-knot nematode (Meloidogyne incognita). Ten Bacillus isolates (KRB-1~10) isolated from the soils of Mt. Naejang. Among them, KRB-5, 9, and 10 showed decomposing activities, and identified as Bacillus subtilis KRB-5, Bacillus amyloliquefaciens KRB-9, and KRB-10 by 16S rRNA sequence analysis, respectively. Under pot experiments using pepper, 100-fold diluted culture broth of three isolates reduced the number of egg sac on roots collected 60 days and 90 days and increased the growth of aerial part compared with the group only treated with Meloidogyne incognita. Especially, the group treated B. subtilis KRB-5 was superior in the growth of pepper. These results suggest that the B. subtilis KRB-5 can be used to control the root-knot nematode on pepper.
Eleocharis kuroguwai Ohwi Ameliorates LPS-mediated Inflammation by Suppressing MAPKs Signaling
Kang-Hoon Kim(김강훈),Eun Young Bae(배은영),Hyun Goo Lim(임현구),Mi Heui Kim(김미희),Tae-Seok Oh(오태석),Seung Woong Lee(이승웅) 한국생명과학회 2020 생명과학회지 Vol.30 No.5
벼 농사에서 마릅으로 불리는 올방개는 문제의 잡초 종류 중 하나로서 제초 작용의 대상이다. 하지만, 올방개는 임상적으로 황달, 해열 및 통경을 위한 전통 의학에 쓰여왔다. 올방개는 오랫동안 임상적으로 사용되어왔음에도 불구하고, 분자생물학 기반의 생물학적 효과는 아직 밝혀지지 않았다. 때문에, 본 연구진은 LPS로 유도된 대식세포 내에서 올방개 추출물 처리에 의한 NO 생산량을 스크리닝 함으로써 항염증 효과를 조사했다. 가장 효과적인 항염증 fraction을 찾기 위해, 본 연구진은 HP20 column chromatography를 이용하여 5 종류의 EtOH sub-fraction을 동정하였다; 20%, 40%, 60%, 80%, 및 100% EtOH. 동정한 sub-fraction 중에서, 60%와 80% 성분에서 가장 유의성 있는 NO 생산의 저해를 나타냈으며, 세포독성 효과도 나타내지 않는 결과를 나타냈다. 추가적으로 80% sub-fraction은 유의성 있는 iNOS 저해와 전염증성 매개체의 mRNA; IL-6, TNF-α, 그리고 IL-1β를 저해하였으며, 이 결과는 MAPKs 세포신호전달과 관련 있는 JNK 및 ERK 단백질의 인산화 저해가 원인임을 밝혔다. 본 연구진의 결과는 올방개 추출물 80% sub-fraction EtOH가 항염증 활성을 가장 효과적으로 저해하는 성분 임을 밝혔으며, 이는 MAPKs 세포신호전달의 과 발현에 의한 염증성 질병의 치료제 후보 성분 일 수 있음을 시사한다. In rice agriculture, Eleocharis kuroguwai Ohwi (olbanggae) is a target for herbicidal intervention as a problem weed although it has also long been used clinically as a traditional medicine for jaundice, fever, and blood flow. E. kuroguwai has been evaluated in many clinical trials, but its molecular biological advantages are still unknown. Here, we investigate the anti-inflammatory effects of E. kuroguwai 80% ethanol extracts by screening NO production in LPS-induced macrophage activation. To find the most effective fractions, we partitioned five sub-fractions using HP20 column chromatography, namely 20%, 40%, 60%, 80%, and 100%. Of these, the 60% and 80% sub-fractions were found to significantly inhibit NO production; there were no toxicological effects at any concentration. In addition, the 80% sub-fraction inhibited significantly the iNOS and the mRNA of the pro-inflammatory mediators IL-6, TNF-α, and IL-1β by inhibiting the phosphorylation of JNK and ERK pathways associated with MAPKs signaling. Our results suggest that the 80% E. kuroguwai sub-fraction has the most significant anti-inflammatory effects of inhibiting iNOS and pro-inflammatory mediators and suppressing the phosphorylation of JNK and ERK. Therefore, the 80% sub-fraction of E. kuroguwai extract may be a therapeutic candidate for inflammatory diseases associated with the overexpression of MAPKs.