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- 저자 : 이승옥 (검색결과 240 건)
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이승옥,이경엽,박수진 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-
In our study, the effect of chemically treated basalt fibers on the mechanical interfacial properties ofbasalt fibers reinforced epoxy composites was investigated. The surface properties of the basalt fiberswere determined by Fourier Transform Infrared (FT-IR) spectroscopy. The surface structure of the basaltfibers was analyzed Atomic Force Microscopy (AFM). The acid and alkali chemical treatments led tosignificant changes in the surface characteristics of the fibers. The chemically treated fibers improved themechanical interfacial properties, interlaminar shear strength (ILSS) and fracture toughness (KIC) of thecomposites. Composites treated with H2SO4 had higher values of ILSS and KIC than the KOH-treatedcomposites. These results are attributed to the improvement of interfacial bonding strength, which wascaused by an increase of the surface roughness of basalt fibers.
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만성 간질환 환자들의 간 기능 정도에 따른 내당능 장애(Glucose Intolerance)의 비교
이승옥,안득수,김대곤,이수택,안혁수 대한소화기학회 1999 대한소화기학회지 Vol.33 No.5
Background/Aims: We investigated correlation between the severity of liver disease and glucose intolerance. Additionally, we compared the rate of glucose intolerance between the patients with pure liver cirrhosis and non-insulin-dependent diabetes mellitus (NIDDM) preceded cirrhosis. Methods: We classified eighty patients with chronic liver disease from L1 to L3 according to the severity liver injury by biochemical factors and the patients with NIDDM preceded cirrhosis were classified into L3-D group. We measured HbA1C, serum insulin and C-peptide and carried out 100 g ora glucose tolerance tests (OGTT). Results: The rate of glucose intolerance was 35% in L2 group and 89% in L3 group, and the rate of diabetic range was 5% and 41%, respectively. In L3 group, fastin blood sugar and HbA1C were in normal range, but the increment of serum insulin, C-peptide and blood glucose in OGTT were higher than in L1 or L2 group. In L3-D group, fasting blood sugar and HbA1C were higher than normal and more increment of blood glucose after oral glucose load was observed than in L3. Significant difference in insulin or C-peptide level was not observed between L3 and L3-D. Conclusions: Glucose intolerance appears to be proportional to the severity of live injury in chronic liver disease. It suggests that OGTT can be an indicator of hepatic injury. We should carefully interpret the glucose intolerance in liver cirrhosis because it shows different pattern from NIDDM preceded cirrhosis.
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원발성 급성 전골수구성 백혈병과 치료불응성 급성백혈병의 비소 감수성
이승옥,김명신,임지향,김용구,한경자,이교영,강창석 대한진단검사의학회 2004 Annals of Laboratory Medicine Vol.24 No.2
Background : Inorganic arsenic trioxide (As2O3) has emerged as a new drug of choice for refractory acute promyelocytic leukemia (APL). But, the curable disease spectrum and the arsenic resistance in association with the expression of multidrug resistance (MDR) proteins are not yet to be established. Methods : Five de novo APL and 20 refractory acute leukemia cases were selected. Leukemic cells were cultured for 24 hr in media with various As2O3 concentrations. Apoptotic cells or damaged cells were measured by a morphologic examination after Wright stain and flow cytometry using annexin V/propidium iodide (PI) stain. The lowest concentration of As2O3 at which greater than 90% of leukemic cells were damaged morphologically was defined as the morphologic arsenic sensitivity of leukemic cells. MDR protein markers including multidrug resistance associated protein (MRP), lung resistance protein (LRP), P-glycoprotein (PGP) and glutathinoe-S-transferase (GST) were analyzed by flow cytometry. Results : The leukemic cells from de novo APLs (in 3 of 5) were sensitive to arsenic trioxide, compared to refractory acute leukemia (only 1 of 20). Of the five MDR proteins examined, only PGP was expressed more in the arsenic resistant cases (in 8 of 21) than in the sensitive cases (none of 4) (P= .032). Conclusions : Refractory acute leukemia had a variable arsenic sensitivity, but were more resistant than de novo APL. The arsenic resistance seems to be related to PGP expression. (Korean J Lab Med 2004; 24: 73-9) 배경 : 치료불응성 급성 전골수구성 백혈병에서 최근 비소가 새로운 치료제로 알려지고 있다. 하지만 현재까지는 비소 치료가 가능한 질병의 범위와 비소 내성과 다약제 내성 단백 발현과의 관계가 확립되어 있지 않다. 방법 : 원발성 급성 전골수구성 백혈병 5예, 치료불응성 급성백혈병 20예를 선정하였다. 골수검체를 다양한 비소 농도에서 24시간 배양한 후, 세포자멸사 또는 손상세포를 Wright 염색을 이용한 형태학적 관찰과 annexin V/PI를 이용한 유세포분석법으로측정하였다. 정상 골수세포를 제외한 백혈병 세포의 90% 이상이손상되는 최저 비소 농도를 백혈병 세포의 형태학적 비소 감수성농도로 정의하였다. 다약제 내성 단백 지표인 MRP, LRP, PGP,GST의 발현정도는 유세포분석기를 이용하여 분석하였다. 결과 : 원발성 급성 전골수구성 백혈병(5예 중 3예)이 치료불응성 급성 백혈병(20예 중 1예)보다 비소에 대한 감수성이 더 높았다. 다약제 내성 단백 중 오직 PGP만 비소 내성군(21예 중 8예)에서 감수성군(4예 모두 음성)보다 유의하게 높게 발현되었다(P=0.032). 결론 : 치료불응성 백혈병에서 비소 감수성은 각 예마다 다양하였지만, 원발성 급성 전골수구성 백혈병보다 비소에 대한 내성이 높았다. 비소 내성은 PGP 발현과 관련이 있는 것으로 사료된다.
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진정하 내시경 역행성 담췌관 조영술에서 적절한 모니터링
이승옥 대한췌담도학회 2011 대한췌담도학회지 Vol.16 No.1
Although incidence of sedation-related complication has been known low, it is closely related with endoscopy related morbidity and mortality. With an advance of endoscopic retrograde cholangiopancreatograpy (ERCP) technique and increased aging of population, the need of procedure to high risk patients such as myocardial ischemia is increasing. To prevent sedation-related complication, identification of high risk patients with adequate history taking and physical examination is mandatory. Adequate monitoring of the patient during sedation is also essential for early detection and prompt management of sedation related complication including hypoxemia and myocardial ischemia. Pulse oximetry is the most commonly used monitoring method and very useful to detect hypoxemia. With the adoption of capnography, inadequate rate or depth of respiration, and upper airway obstruction can be identified before substantial hypoxemia occurrence. Hemodynamic monitoring should be performed regularly. ECG monitoring is recommended in selected patient who has cardiovascular risk. A well educated, specialized person is recommend for monitoring so endoscopist can concentrate the procedure only. Adequate emergency equipments and pharmacologic agents are also should be prepared.
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