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이세진,김유나,김형일,정재호,형우진,노성훈,손태일 대한위암학회 2015 Journal of gastric cancer Vol.15 No.4
Purpose: Various laparoscopic wedge resection (LWR) techniques requiring gastrotomy for gastrointestinal stromal tumors (GISTs) of the stomach have been applied to facilitate tumor resection and preserve the remnant gastric volume. However, there is the possibility of cancer cell dissemination during these procedures. The aim of this study was to assess the oncologic safety of LWR with gastrotomy (LWR-G) compared to LWR without luminal exposure. Materials and Methods: Clinicopathologic and operative results of 193 patients who underwent LWR for gastric GIST were retrospectively analyzed from 2003 to 2013. We stratified the patients into two groups: LWR-G and LWR without gastrotomy (LWR-C). Clinicopathologic features, short-term outcomes, and long-term outcomes were compared. Results: A total of 26 patients underwent LWR-G, and 167 patients underwent LWR-C. The LWR-G group showed significantly more anterior wall-located (n=10, 38.5%), intraluminal (n=20, 76.9%), and ulcerative (n=13, 50.0%) tumors than the LWR-C group (n=33, 19.8%; n=96, 57.5%; n=46, 27.5%, respectively). Postoperative short-term outcomes did not differ between the two groups. When tumor staging was compared, no statistical difference was noted. There was no recurrence in the LWR-G group, while 2 patients in the LWR-C group experienced recurrence. The two recurrences in the LWR-C group were found in the liver and in the remnant stomach at 63 and 12 months after the operation, respectively. No gastric GIST-related death was recorded in any group during the study period. Conclusions: LWR-G for gastric GIST is an oncologically safe procedure even for masses with ulcerations.
Cefepime-induced neurotoxicity
이세진 대한신경집중치료학회 2019 대한신경집중치료학회지 Vol.12 No.2
Cefepime, a widely used fourth-generation cephalosporin, has been reported to cause neurotoxicity because it crosses the blood-brain barrier. Although cefepime-induced neurotoxicity (CIN) occurs in patients with renal dysfunction administered a high dosage, CIN has also been reported in patients with normal renal function administered the appropriate dosage. CIN is characterized by toxic encephalopathy and electroencephalography abnormalities, such as triphasic wave, currently renamed as generalized periodic discharge (GPD) with triphasic morphology, and nonconvulsive status epilepticus (NCSE). Toxic encephalopathy appears 2 to 6 days after cefepime administration and disappears 3 days after discontinuation of cefepime. Electroencephalography abnormalities in most reported cases are GPD with triphasic morphology rather than NCSE. CIN is reversible in most cases if early detection and discontinuation of cefepime is possible, which is the only definitive treatment; however, anticonvulsant therapy is unnecessary except for patients with convulsive seizures or definite NCSE. Emergent hemodialysis may also be helpful in life-threatening situations.
이세진,Zhuang Yao,Yu Meng,Huong Giang Le,전혜성,유지연,김정환 경상국립대학교 농업생명과학연구원 2020 농업생명과학연구 Vol.54 No.4
A γ-aminobutyric acid (GABA) producing microorganism was isolated from Sun-Tae Jeotgal, a Korean traditional fermented seafood. Two thousand presumptive lactic acid bacteria (LAB) isolates were screened for GABA production by thin layer chromatography. One isolate, T118, produced GABA profusely, and identified as Lactobacillus brevis. Growth of Lb. brevis T118 was examined during 120 h cultivation in MRS broth under different conditions. Lb. brevis T118 grew well at 30-37℃, initial pH of 4-7, and up to 5% NaCl (w/v). A gene, gadB, encoding glutamate decarboxylase (GAD) was cloned by PCR. gadC encoding a glutamate/GABA antiporter was cloned and gadC located immediately upstream of gadB, indicating gadCB operon structure. The operon structure was confirmed by reverse transcription (RT)-PCR. gadB was overexpressed in Escherichia coli BL21 (DE3) and recombinant GAD was purified. The size of recombinant GAD was 54.4 kDa by SDS-PAGE, which matched well with the calculated size from the nucleotide sequence.
The Effects of State Smart Growth Management and Local Contexts on Local Open Space Preservation
이세진 서울대학교행정대학원 2013 The Korean Journal of Policy Studies Vol.28 No.1
This study explores the effects of state smart growth management and local contextual factors—in particular, aspects of hierarchical governance and the political market framework—on local open space preservation. It takes into account state intervention in local affairs, including state requirements for local planning practices in general and for open space preservation in particular. It also tests local contextual factors such as political and informal institutions,interest groups, and community and physical characteristics, using hierarchical linear modeling. The findings suggest that counties are more likely to preserve open space when the state government strongly intervenes in local planning practices. The county manager form of government and high population density are negatively associated with open space preservation, while high demands for growth control and the presence of active environmental interest groups are positively associated with it.
인공지능 적용에 관한 교실 기반 연구: 초등영어 학습 부진아의 기계번역기 사용과 인식을 중심으로
이세진,장경석,이경미 한국초등영어교육학회 2023 초등영어교육 Vol.29 No.1
This study aims to explore the use of Artificial Intelligence (AI) to support struggling young learners and provide insights for applying AI to teaching and learning English in the primary classroom. AI is suggested to be an innovative technology that will shape the future of education. Special attention is paid to how the future of education can be unveiled in real classrooms that adopt AI and how teachers and students can benefit from it. The participants of this study were three pupils with learning difficulty, a homeroom teacher, two English subject teachers, and two external experts. Data was collected via Q-sort, classroom observations, interviews with the participating students, a diagnostic test, a sentence completion test, student performance, and a research log. The triangulated analysis of the collected data revealed that the students heavily relied on AI in the beginning, then gradually developed their routines with AI use, and finally used it less, which gave them a sense of independence. It is further shown that AI relieved the anxiety of the low-achieving English learners and gave them confidence by providing them with options when faced with difficulties in class. These findings provide insights for understanding the directions of AI applications in English learning and teaching, leading to support for low-achieving pupils’ learning and policy for basic education guarantee.