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고려홍삼 성분이 암독소 호르몬-L의 체지방 분해작용에 미치는 영향
이성동,황우익 한국식품영양학회 1995 韓國食品營養學會誌 Vol.8 No.2
본 연구는 지방분해 및 식욕억제 인자로 알려진 암독소 호르몬-L의 체지방 분해작용에 미치는 각국 인삼의 petroleum ether(PE) 추출불의 영향을 비교·관찰하고자 시도하였다. PE에 의해 추출되어진 지질성분의 수율은 고려홍삼, 중국홍삼 및 미국백삼이 각 0.64, 0.47 및 0.58%로 고려홍삼이 가장 높았다. 시험관내에서 PE 추출물의 체지방 분해작용 억제율은 2㎎/㎖ 반응농도에서 고려홍삼, 중국홍삼 및 미국백삼이 각 55.1, 50.0 및 44.9% 였고, 체지방 분해작용 총 억제활성은 각 18, 12 및 13 unit로 역시 고려홍삼이 모두 가장 높았다 This study was devised to observe the inhibitory effects of 3 kinds of petroleum ether extracts(percolation by petroleum ether) from Korean red ginseng, Chinese red ginseng and American white ginseng on a lipolytic action of Toxohormone-L which has been known as lipolytic and anorexigenic factors. Toxohormone-L was obtained by partial purification of the ascites fluid from mice which had been inoculated with sarcoma-180. The yields of petroleum ether extract from Korean red ginseng, Chinese red ginseng and American white ginseng were 0.64, 0.47 and 0.58% respectively, indicating that the yield of Korean red ginseng was the highest. In vitro, at the concentration of 2㎎/㎖, the inhibition rate of lipolysis by the petroleum ether extract of Korean red ginseng, Chinese red ginseng and American white ginseng were 55.1, 50.0 and 44.9% respectively, and the total inhibitory activity per gram of ginseng material were 18, 12 and 13 unit respectively, indicating that the Korean red ginseng was the most effective in the inhibition of the lipolysis.
이성동 高麗大學校 倂設 保健大學 保健科學硏究所 1997 保健科學論集 Vol.23 No.1
Growing(94∼156g) and adult(340∼401g) rats of Sprague-Dowley strain were used as experimental subject to investigate the effect of Korean red ginseng ingredients on survival period in during the starvation. The body weight gained, feed intake, feed efficiency, protein efficiency and body weight decrease rate after starvation in growing rats given 1% Korean red ginseng extract solution showed no significant change during the restricted supply of diet(lhr7day), and the survival period showed the tendency to decrease by severe restricted supply of diet There was no significant differences in body weight decrease and the survival period(day) after starvation in adult rats group given 1% Korean red ginseng extract Body weight decrease and survival period in growing and adult rats group endowed with 1% Korean red ginseng extract containing 5% alcohol indicated no significant change than that of the control(5% alcohol solution) group.
고려 홍삼 다당체가 암독소 호르몬-L의 체지방 분해작용에 미치는 영향
이성동,황우익 高麗大學校 倂設 保健大學 保健科學硏究所 1999 保健科學論集 Vol.25 No.1
This study was devised to observe the inhibitory effects of 2 kinds of ethanol treatment precipitate (crude acidic polysaccharide) from Korean red ginseng and Chinese red ginseng on a lipolytic action of Toxohormone-L which has been known as lipolytic and anorexigenic factors. Toxohormone-L was obtaind by partial purification of the ascites fluid from mice which had been inoculated with sarcoma-180. The yields of crude acidic polysaccharide from Korean red ginseng and Chinese red ginseng were 63.5 and 61,3% respectively, indicating that the Korean red ginseng was the higher. In vitro. the total inhibitory activity per gram of ginseng material were 4,928 and 4,254 unit respectively, also indicating that the Korean red gingeng was the better effective in the inhibition of the lipolysis. In vivo, once in 3 days injection of the red ginseng polysaccharide extracts(40㎎/㎖ in saline soln.) with 0.64 g/㎏ of body weight to the mice bearing sarcoma-180 was not effective against the extension of their life span. On the contrary, the life span of the mice were rather shotened by the injection of Chinese red ginseng polysaccharide extract, as compared to that of control. But body weight gain of sarcoma-180 bearing mice decreased significantly by administration of Korean red ginseng polysaccharide extract compared to those of the control or other red ginseng treated group (P<0.05).
성장기 흰쥐의 족삼리(ST-36) 침자가 혈액성분에 미치는 영향
이성동,윤범철,류정록,최태암 高麗大學校 倂設 保健大學 保健科學硏究所 2000 保健科學論集 Vol.26 No.1
Acupuncture, an important branch of oriental medicine, has been practiced for many centuries and has been proved to be an effective treatment for all sorts of disease. However, the exact mechanism on effects of acupuncture was uncertain. Recently investigation for the mechanism of acupuncture has concentrated to human and animals. So, This study was to determine effects of ST-36 acupuncture stimulation on blood component in growing rats. For this study, 24 male Sprague-Dawley rats weighting 159?13g were randomly assigned into three groups; A4 group, A10 group, and control group. In A4 group, four times acupuncture were performed at both ST-36 every other days and in A10 group, ten times acupuncture. The results obtained were as follows; 1. Total protein level was significantly increased, particularly in A10 group; albumin level was also significantly increased. 2. Serum glucose level was significantly increased. 3. Triglyceride level was significantly increased in A4 group; phospholipid level had no changes; free fatty acid level was significantly decreased particularly in A10 group. 4. Total cholesterol level was rarely affected by acupuncture: HDL-C and LDL-C levels were affected by the number of times of acupuncture, that is, HDL-C levels were increased, and LDL-C level decreased in A4 group, while HDL-C level decreased and LDL-C level increased in A10 group. 5. Serum amylase activity was not significantly changed.