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대계(大?)가 LPS로 유도된 Mouse BV2 Microglial cells의 염증반응에 미치는 영향
김영선,이성근,이기상,Kim, Young-Sun,Lee, Seoung-Geun,Lee, Key-Sang 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Cirsii Japonici Herba(CJ) is a wild perennial herb found in many areas of Korea as well as China and Japan, which has been used to treat bleeding and inflammation. Silibinin is the main flavonoid extracted from milk thistle (Cirsii Japonici Herba). It exhibits potent antioxidant activity and anti-inflammatory effect. In this study, the effect of CJ and silibinin extract on lipopolysaccharide-induced inflammation was investigated using MTS assay, RT-PCR, western blot, and nitric oxide detection on mouse BV2 microglial cell lines. In the present results, CJ and silibinin extract suppressed nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of COX-2 and iNOS gene expression in BV2 cells. Moreover, CJ and silibinin also repressed some lipopolysaccharide-induced signaling molecules. Importantly, catalase-induced COX-2 and iNOS expression needed activations of $NF-{\kappa}B$, PI3K/Akt, and MAPK, which were important for the transcriptional up-regulation of COX-2 and iNOS. CJ and silibinin interaction on BV2 cells down-regulated $NF-{\kappa}B$-dependent proinflammatory cytokine (IL-2,IL-6) expression. They are involved in the regulation of inflammatory responses. These data shows that CJ and silibinin exerts anti-inflammatory and analgesic effects, probably by suppression of COX-2 and iNOS synthase expression in BV2 microglial cells.
정맥 혈관내 He-Ne 레이저 조사가 고지혈증 환자의 지질 수치에 미치는 영향
유현희,손지영,이성근,윤종민,이기상,Ryu, Hyun-Hee,Son, Ji-Young,Lee, Seoung-Geun,Yun, Jong-Min,Lee, Gi-Sang 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
In order to determine the effect of intravenous He-Ne laser irradiation, values of serum total cholesterol, Triglyceride, LDL-cholesterol and HDL-cholesterol were measured. Twenty three patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University were treated with He-Ne laser irridiation and analyzed by Paired T-test of SPSS program. The following results were obtained : The serum Total cholesterol and LDL-cholesterol of patients treated with He-Ne laser irradiation showed a significant(P<0.05) decrease, and the serum Triglyceride and HDL-cholesterol of patients treated with He-Ne laser irradiation showed no significant(P<0.05) effects.
고혈압-뜸 임상시험 참여자들의 혈압 관리행동에 대한 질적연구
문아지,김태정,이성근,김남권,이기상,Moon, A-Ji,Kim, Tae-Jung,Lee, Seoung-Geun,Kim, Nam-Kwen,Lee, Key-Sang 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4
Objectives : The purpose of this study which adopted a qualitative method was to evaluate blood pressure management behaviors of pre- and stage 1 hypertension patients and to provide fundamental data for developing a strategy about proper oriental medical treatment through analyzing factors related to a moxibustion clinical trial. Methods : Semi-structured interviews that focused on personal experiences with hypertension and its management were conducted with 10 hypertensive patients. The interviews lasted for approximately 50 minutes. Results : Most participants recognized that the direct cause of high blood pressure was unhealthy behavior rather than inheritance. Thus, the hypertensive patient believed they could recover their blood pressure to a normal level through removing the direct cause of hypertension instead of taking drugs. The reasons for these statements were that the drugs for controlling hypertension are not natural and they may have side effects. On future management plan of patients, most of them will continue to keep moxibustion and healthy behavior in the well-controlled blood pressure group. However in the uncontrolled blood pressure group, there was an increasing tendency to begin medication. Conclusions : For developing a strategy for an individual approach to hypertension management, we need to develop a client-centered attitude and strategy. That is, we need to tailor our approach to individual cases to avoid generalizations and stereotyping when developing an adherence increasing strategy.
김태정,문아지,이성근,이기상,Kim, Tae-jung,Moon, A-ji,Lee, Seoung-geun,Lee, Key-sang 대한중풍순환신경학회 2012 대한중풍.순환신경학회지 Vol.13 No.1
Amyotrophic lateral sclerosis(ALS) is a progressive disorder that causes degeneration of motor neurons of the brain and spinal cord. It is characterized by loss of motor neurons leading to muscle weakness, and sensation and mental function stay intact during the course of the disease. Diagnostic tests include magnetic response imaging(MRI), electromyogram(EMG), muscle biopsy, and blood tests. In order to a definitive diagnosis of ALS, damage must be evident in both upper and lower motor neurons. When three limbs are sufficiently affected, the diagnosis is ALS. There is no cure for ALS. We experienced one case of ALS, the patients was diagnosed as ALS by EMG and symptoms. We diagnosed her as ShinEumHur(SEH) and treated by Choakwiyeum(左歸飮). We report the change of her symptoms through oriental medical treatment.
H2O2와 Aβ로 유도된 pc12 cell에서 생산조인(生酸棗仁) 수추출물의 항산화 및 항치매 효과
이상원 ( Sang Won Lee ),김대현 ( Dae Hyun Kim ),윤종현 ( Jong Hyun Yun ),김진우 ( Jin Woo Kim ),정은영 ( Ejun Young Jung ),이성근 ( Seoung Geun Lee ),이기상 ( Key Sang Lee ),김태헌 ( Tae Heon Kim ),류영수 ( Yeoung Su Lyu ),강형원 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3
Objective : The antioxidant and anti-Alzheimer effects of Semen Ziziphi Spinosae (SZS) water extract against the amyloid beta peptide (1-42) or H2O2-induced oxidative damage and cell death were investigated in rat pheochromocytoma line PC 12. Methods : The cells were incubated with SZS water extract and oxidative damage-inducing materials, amyloid beta peptide (1-42) or H2O2 for 24 h. The cellular viability was assessed by WST-1 assay, cytotoxic damage by LDH activity assay, oxidative damages of cells by fluorescence spectrophotometric method, and apoptosis by TUNEL staining assay. Results and Conclusions : 1. Preincubation of the cells with SZS water extract prior to amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) exposure elevated the cell survival close to the control and decreased the level of LDH activity and the fluorescence from the cell homogenates and TUNEL staining of the cells, compared to only amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) treated conditions . 2. Our study suggests that Semen Ziziphi Spinosae (SZS) water extract has protective effects against amyloid beta peptide (1-42) or H2O2-induced cell toxicity through the antioxidation mechanism, which might be beneficial for the treatment of Alzheimer`s disease.
김영은,김일화,이재화,이성근,이기상,Kim, Young-Eun,Kim, Il-Wha,Lee, Jae-Hwa,Lee, Seoung-Geun,Lee, Key-Sang 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4
Parkinson's disease is a slowly progressive degenerative disorder of the central nervous system. It is characterized by tremor when muscles are at rest, increased muscle tone, slowness of voluntary movements, and difficulty maintaining balance. In oriental medicine, these symptoms are diagnosed as yin(陰)-deficiency of liver and kidney, deficiency of qi(氣) and blood, retention of phlegm(痰), qi-stagnation and blood stasis. In this case, we diagnosed patients as deficiency of qi(氣) and blood type according to symptoms and treated by herbs that strengthen yang and benefiting yin for two weeks, while maintaining existing parkinson's western medication. After treatment, clinical symptoms were improved, while UPDRS (Unified Parkinson's Disease Rating Scale) score was decreased. These cases suggest that oriental medicine therapy maybe effective in the treatment of Parkinson's disease.