기억성 경도인지장애 및 알츠하이머 치매 환자에서 해마, 편도체, 뇌들보, 내후각 피질과 혈중 지질, 호모시스테인, 엽산 농도와의 연관성

이상준,김태형,허량,최승은,이봉주,김경미,이정구,김홍대,문치웅,김영훈,Lee, Sang Jun,Kim, Tae Hyung,Huh, Lyang,Choi, Seung Eun,Lee, Bong Ju,Kim, Gyung Mee,Lee, Jung Goo,Kim, Hong Dae,Mun, Chi Woong,Kim, Young Hoon 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type. Methods The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis. Results In patients with aMCI, old age (> 80) and APOE ${\varepsilon}4$ carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume. Conclusions Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.

생체 인식 시스템을 위한 심전도 개인인식 알고리즘 개발

이상준,김진권,이영범,이명호,Lee, Sang-Joon,Kim, Jin-Kwon,Lee, Young-Bum,Lee, Myoung-Ho 대한의용생체공학회 2010 의공학회지 Vol.31 No.5

This paper is about the personal identification algorithm using an ECG that has been studied by a few researchers recently. Previously published algorithm can be classified as two methods. One is the method that analyzes ECG features and the other is the morphological analysis of ECG. The main characteristic of proposed algorithm uses together two methods. The algorithm consists of training and testing procedures. In training procedure, the features of all recognition objects' ECG were extracted and the PCA was performed for morphological analysis of ECG. In testing procedure, 6 candidate ECG's were chosen by morphological analysis and then the analysis of features among candidate ECG's was performed for final recognition. We choose 18 ECG files from MIT-BIH Normal Sinus Rhythm Database for estimating algorithm performance. The algorithm extracts 100 heartbeats from each ECG file, and use 40 heartbeats for training and 60 heartbeats for testing. The proposed algorithm shows clearly superior performance in all ECG data, amounting to 90.96% heartbeat recognition rate and 100% ECG recognition rate.

스월유동장의 화염전파에 미치는 난류특성의 영향에 관한 연구

이상준,이종태,이성열,Lee, Sang-Jun,Lee, Jong-Tae,Lee, Seong-Yeol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.10

Flow velocity was measured using a hot wire anemometer. Turbulence intensity was in proportion to mean flow velocity regardless of swirl velocity. And integral length scale has proportional relation with swirl velocity regardless of measurement position. Flame speed calculated by radius of visualized flame was increased and then decreased according to lapse of time from spark. Maximum flame speed was increased according to increase of turbulence intensity. Burning speed and flame transport effect increased with increase of swirl velocity, but ratio of burning speed to flame speed decreased with increased of swirl velocity. Mass fraction burned versus volume fraction burned was increased in proportion to the increase of turbulence intensity, caused by increase of combustion promotion effect according to increase of turbulence intensity and scale.

과학기술위성3호 소형영상분광기 발사모델 환경시험 결과

이상준,김정현,이준호,이치원,장태성,강경인,Lee, Sang-Jun,Kim, Jung-Hyun,Lee, Jun-Ho,Lee, Chi-Won,Jang, Tae-Sung,Kang, Kyung-In 한국광학회 2011 한국광학회지 Vol.22 No.4

과학기술위성3호 부탑재체인 소형영상분광기 COMIS(Compact Imaging Spectrometer)는 400 - 1050 nm의 관측 대역에서 분광 관측을 수행하는 영상 분광기이다. COMIS는 2012년 고도 700 km의 원 궤도에서 발사 된 후 27 m의 공간분해능과 2 - 15 nm의 파장 분해능을 갖도록 설계되었다. 본 논문에서는 COMIS 비행 모델의 환경시험 수행결과를 기술한다. 발사 환경인 진동 가진에 의한 영상분광기의 광학적, 구조적인 변화 여부와 우주환경인 열.진공 상태에서의 기능 시험을 수행하여 안정성 및 신뢰성을 검증 받았다. 우주공간에서의 환경으로 일컬어지는 고진공($10^{-5}$ torr이하)과 $-30^{\circ}C{\sim}35^{\circ}C$의 고온 및 저온의 열적 변화 상태를 모사하는 시험에서 정상적인 기능을 보였고, 10 grms의 랜덤 진동 가진 전.후의 고유 진동수는 1% 이내의 변화량을 보였다. 환경시험 전 후로 영상분광기의 변조전달함수(MTF, Modulation Transfer Function) 측정을 하여 광학 성능이 유지됨을 확인하였다. 환경시험을 마친 영상분광기는 현재 과학기술위성3호 본체와의 조립을 진행 중에 있으며 2012년 발사 예정에 있다. A compact imaging spectrometer (COMIS) was developed for a microsatellite STSAT-3. The satellite is now rescheduled to be launched into a low sun-synchronous Earth orbit (~700 km) by the end of 2012. Its main operational goal is the imaging of the Earth's surface and atmosphere with ground sampling distance of 27 m and 2 - 15 nm spectral resolution over visible and near infrared spectrum (0.4 - 1.05 ${\mu}m$). A flight model of COMIS was developed following an engineering model that had successfully demonstrated hyperspectral imaging capability and structural rigidity. In this paper we report the environmental test results of the flight model. The mechanical stiffness of the model was confirmed by a small shift of the natural frequency i.e., < 1% over 10 gRMS random vibration test. Electrical functions of the model were also tested without showing any anomalies during and after vacuum thermal cycling test with < $10^{-5}$ torr and $-30^{\circ}C\;-\;35^{\circ}C$. The imaging capability of the model, represented by a modulation transfer function (MTF) value at the Nyquist frequency, was also kept unvaried after all those environmental tests.

스월유동장에 있어서 연소속도에 미치는 난류특성의 영향에 관한 연구

이상준,이종태,이성열,Lee, Sang Jun,Lee, Jong-Tai,Lee, Song-Yol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.1

Flow velocity was measured by, use of hot wire anemometer. Turbulence intensity was in proportion to mean flow velocity regardless of swirl velocity. And integral length scale has proportional relation with swirl velocity regardless of measurement position. Turbulent burning speed during flame propagation which was determined by flame photograph and gas pressure of combustion chamber was increased with the lapse of time from spark and was decreased a little at later combustion period. Because of combustion promotion effect, turbulent burning speed was increased according to increase of turbulence intensity. Burning speed ratio i.e. ratio of turbulent burning speed ($S_BT$) to laminar burning speed ($S_BL$) was found out by use of turbulence intensity u' and integral length scale $l_x$ , $\delta_L$ is width of preheat zone in laminar flame.

북한지역의 국토개발과 수자원분야의 과제

이상준,Lee, Sang-Jun 한국수자원학회 2015 물과 미래(한국수자원학회지) Vol.48 No.7

고려왕릉의 구조 및 능주(陵主) 검토

이상준,Lee, Sang June 국립문화재연구원 2012 헤리티지:역사와 과학 Vol.45 No.2

개성과 강화에는 다수의 고려왕릉이 남아 있다. 이 왕릉들은 전대의 능제적 전통을 이어받아 고려만의 독창적인 능제를 완성, 조선왕릉에 전승시켰다. 고려왕릉의 일반적인 특징은 우선 능역을 3~4단으로 구획하고 능제에 맞추어 각 단에 석물과 정자각을 배치하였다. 석실은 입구를 남쪽에 두고 있으며, 벽석은 수직으로 쌓아올렸고, 천장은 평천장이다. 석실바닥에는 중앙에 관대를 놓고, 그 주변에 전돌을 깔았다. 벽면과 천장에는 회칠을 하고 그림을 그렸다. 그런데 석실내부의 구조를 자세히 살펴보면, 이런 일반적인 특징 외에 몇 가지 세부적인 차이가 발견된다. 고려초기에는 1단 평행고임천장과 통돌관대, 유물부장대 그리고 식물소재의 벽화가 조합되어 나타나며, 이는 과도기적 형태를 거쳐 12세기후반을 기점으로 평천장, 장대석재벽석, 석주형석재조립관대로 변하고 있음을 알 수 있다. 한편, 몇몇 왕릉은 출토된 시책(諡冊) 편을 통해 능주를 명확히 규정할 수 있으며, 석실내부에서 출토된 청자는 해당 왕릉의 축조연대와 상당한 시기차가 있음을 확인할 수 있었다. 이점은 도굴 등 왕릉의 파괴로 인한 후대 보수과정에서 당대 유물이 매납된 것으로 판단된다. 마지막으로 기록상 왕릉의 장지방향과 발굴결과를 비교검토하여 능주가 누구인지를 추적해 보았다. 그 결과 충목왕명릉 등 일부 왕릉은 능주의 비정이 잘못되었음을 확인할 수 있었다. There remain many royal tombs of the Goryeo Dynasty in Gaeseong and Ganghwa. During the Goryeo Dynasty, these royal tombs were taken over tradition of tomb construction style from previous generation, and they completed their own inventive style. Furthermore they handed down those style to the Joseon Dynasty. The area of tomb was divided into 3 or 4 steps, and stone figures and T-shaped houses for sacrifice were arranged on each steps. It was the stone chamber of lateral opening style which had an entrance to southward, and it was formed as a rectangular box-shaped with a pile of stone walls and a flat ceiling. There was a coffin stand in the middle of floor, and traditional bricks were around them. The wall side and ceiling had been whitewashed and painted pictures. These are general characteristics for the tomb construction style of the Goryeo Dynasty. By the way, we can notice a number of features except those general things with inspection in detail. In early days, we confirmed 1step-parallel fulcrum ceiling, coffin stand of all in one stone, bier of burial artifact, and mural of plant material as a set, but they were changed as flat ceiling, Red-stone wall with rectangular stone, coffin stand set as stone pillar through the period of transitional form as of in the late 12th century. In case of several royal tombs, the fragments of king's epitaph which were confirmed from tombs could be defined owners clearly, and there were considerable timing difference between the large numbers of celadons which were excavated with the fragments of king's epitaph and recording chronologically of stone chamber structure. The reason for timing difference is that posterity artifacts were buried through repairing courses by occasion of destruction caused by robbing of the royal tombs. Meanwhile I inferred the existing hypothesis about owners of royal tombs and autonym ones in comparison the burial spot direction of hypothesis ones and outcomes of excavation. Therethrough, some hypothesis about owners of royal tombs such as Myung-neung which was assumed as tomb of the King Choongmok were not correct.

디코딩 후 전달 중계 시스템에서 부분 중계 노드 선택 기법 기반 기회적 협력 방식의 아웃티지 성능 분석

이상준,이인호,Lee, Sangjun,Lee, In-Ho 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.8

본 논문에서는 듀얼 홉 중계 시스템에서의 협력 전송 방식과 비협력 전송 방식간의 효율적인 선택을 통하여 아웃티지 성능을 향상시키는 기회적 협력 방식에 대해 연구한다. 특히, 디코딩 후 전달 중계 시스템에서 부분 중계 노드 선택 기법을 이용한 기회적 협력 방식의 아웃티지 성능을 분석한다. 여기서, 독립적이고 균일 분포를 갖는 레일레이 페이딩 채널을 가정하여 정확한 아웃티지 확률 표현식과 점근적인 아웃티지 확률 표현식을 유도한다. 수치적 결과에서, 유도된 표현식들을 검증하고, 데이터율의 목표치와 중계 노드 수에 대한 아웃티지 성능을 분석한다. 또한, 기존의 협력 방식과 기회적 협력 방식의 아웃티지 성능을 비교한다. In this paper, we study the opportunistic cooperation scheme that improves the outage performance through the efficient selection between a cooperative mode and a non-cooperative mode. Especially, in decode-and-forward relaying systems, we analyze the outage performance for the opportunistic cooperation using partial relay selection, where closed-form expressions of exact and asymptotic outage probabilities are derived assuming independent and identically distributed Rayleigh fading channels. In the numerical results, we verify the derived expressions, and investigate the outage performances for various target data rates and different numbers of relays. Also, we compare the outage performances of the conventional cooperation scheme and the opportunistic cooperation scheme.

정천화담강기탕(定喘化痰降氣湯)이 ovalbumin으로 유발(誘發)된 천식(喘息)의 조직학적(組織學的) 변화(變化)에 미치는 영향(影響)

이상준,박지현,최해윤,김종대,Lee, Sang-Jun,Park, Ji-Hyeon,Choi, Hae-Yun,Kim, Jong-Dae 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1

Objectives : In order to study the effect of oral administration of Jungcheonhwadamgangki-tang against the asthma. Method : Asthma was induced to Balb/c mouse with ovalbumin by using method of Hatfield et al. It was observed the changes numbers and morphology of the mast cells in the trachea, numbers of mucous secretory cell in the bronchus, morphology of the bronchus, ultramicroscopical appearance of surface of trachea and number of cilia and mucous secretory cells by scanning electron microscope. Result : 1. Degranulation and decreasing of the numbers of mast cells were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. 2. Hypertrophy of mucous membrane of bronchus In the lung, infiltration of inflammatory cells, increasing of mucous secretory cells in the bronchus were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. 3. Shedding, decreasing of cilia cells and increasing of mucous secretory cells in the surface of the trachea were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. Conclusion : It is considered that Jungcheonhwadamgangki-tang has somewhat favorable effects on the asthma because the asthma specific series of abnormalities in respiratory system were decreased after oral administration of Jungcheonhwadamgangki-tang in this study. In future, it is needed that the toxicological and dosage specific study of Jungcheonwhadamgangki-tang to use against bronchial asthma with safe.

고려 강도궁궐의 위치와 범위 검토

이상준,Lee, Sang-jun 국립문화재연구원 2014 헤리티지:역사와 과학 Vol.47 No.3

강화는 비록 짧은 기간이긴 했지만 궁궐을 비롯한 여러 시설물이 즐비한 고려의 도성이었다. 하지만 도성의 핵심시설인 궁궐의 실체가 확인되지 않고 있기 때문에 중세도성으로서의 역사적 위상을 발현하지 못하고 있다. "고려사"에 의하면 강도궁궐은 개경궁성을 모방하였다고 한다. 이 사실을 전제한다면, 강도궁궐의 실체는 원형이 잘 보존되어 있는 개경궁성터에서 찾을 수 있을 것이라 생각된다. 개경궁성의 특징은 도성의 남북중심 축선에서 서편으로 치우친 곳에 입지하고, 궁성의 동편에는 '동지(東池)'가 위치한다. 그리고 궁성의 중앙부에는 탁월한 고도의 구릉이 남쪽으로 돌출되어 있고, 이 구릉을 감싸고 두 줄기의 가지하천이 흘러 주류하천에 합수된다. 강화에서 이상 개경궁성의 특징들을 적용해 볼 수 있는 곳은 관청리 '궁골'일대이다. 이곳에서는 예로부터 많은 청자들이 수습되었다고 하며, 중앙부에는 탁월한 고도의 구릉이 남아있다. 이 구릉을 감싼 두 줄기의 하천은 남쪽으로 흘러 주류하천인 동락천에 합수된다. 한편 관청리 405번지 유적의 발굴조사 결과는 이곳이 연못이었음을 추측케 한다. 그렇다면 이 유적은 궁궐의 동편에 입지하는 개경의 '동지'와 같은 성격의 유적으로 판단된다. 그리고 지적도에서 확인한 대형도로는 개경도성의 남북방향 주간선도로에 비견된다. 그러므로 강도궁궐은 개경궁성과 같이 이 두 유구의 서편에 입지하여야만 한다. 그곳이 바로 '궁골'인 것이다. 지적도에는 '궁골' 일대에 호상(弧狀)의 도로에 의해 구획된 복주머니 형태의 평면이 확인되는데, 개경의 궁성모습과 흡사하다. 이 호상도로 내부에 궁궐 전각의 일부로 생각되는 관청리 659-2번지 유적이 위치하고 있다. 이상과 같이 개경궁성의 특징, 고지도 및 지적도, 고고자료의 검토를 통해 얻은 결론은 강도궁궐이 강화읍 관청리 '궁골'일대에 위치해 있었을 것이라는 것이며, 그 범위는 상기한 호상도로의 내부라는 것이다. Gangwha was a capital city of Goryeo, in spite of short-term occupation, where various national facilities such as palace stood in a row. Nevertheless, its historic importance has been undervalued owing to undiscovered palace. According to ${\ll}Goryeosa{\gg}$, palace in Gangwha was built in imitation of that of Gaegyeong. If it is true, the site of the old palace in Gaeseong as an original could give significant information for that of Gangwha. The distinct feature of Gaegyeong is that the palace was located in the west area of the centerline from north to south and pond lay in the east side. There is a mountain in the center of capital and two rivers runs along side the mountain. Gunggol at Gwancheong-ri is a best place where structural peculiarities of Gaegyeong can be applicable to Gangwha. There is an area of celadon distribution and is some topographic similarities such as central mountain, two rivers are quite similar. It is assumable that excavation result of no. 405 Gwancheongri reflects the function of east pond and thoroughfare responds to main street from north to south of Gaegyeong. After all the analysis from archaeological information, old maps, cadastral maps, topographic similarities and so on, Gunggol at Gwancheong-ri within an arc shape road is a most suitable place as palace in Gangwha.