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2-D microphase properties of novel ceramides assembled to intercellular lipid membranes
이보령,성민철,김진웅 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.1
In this study, we investigated how 1-O-acylceramide (CENP) and ceramide with ultra-long chain (C24-C32) (CULC) associate with ceramide NP (CNP), respectively. To characterize their structure, we fabricated a 2-D lipid membrane composed of ceramides/stearic acid/cholesterol, which mimics the intercellular lipid in our stratum corneum, by using Langmuir-Blodgett technology. The π-A isotherms of the lipid membranes revealed that CENP disturbed the association of lipid membranes, whereas CULC led to formation of closely packed membranes. Moreover, CENP showed a slower phase transition compared with CULC, which was confirmed by fluorescence microscopy. In addition, through the AFM analysis, we verified the CULC had the higher domains by associating between CNP and CULC more tightly than between CENP and CNP. We expect these findings of novel ceramides are able to contribute to the developed skin barrier function.
신경병증성 통증 쥐 모델에서 전신적으로 투여한 Ketamine의 선행진통 효과
이보령,김진윤,박선규,구길회,우영철,정용훈,백종화,박정원,이인구 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.2-3
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been used for the treatment of neuropathic pain. But the preemptive analgesic effect of ketamine in neuropathic pain is not widely known. The purpose of this study was to evaluate the preemptive effect of systemic ketamine in neuropathic pain rat model. Eighteen male rats were divided into ketamine (n=9) and control (n=9) group. The rats were injected with ketamine (5% ketamine 20 mg/kg, intraperitoneal) at 30 min before operation in ketamine group but normal saline in control group. Neuropathic pain model was made by L5 spinal nerve ligation. The spontaneous pain behaviors (weight bearing, licking, limping, motor weakness, foot deformity) and foot withdrawal response frequency (RF) by von Frey filament (VFF, 0.4-2.0-10.0-15.0 g) were measured at pre and post operative 3, 5, 7, 14, 21 and 28th day (POD3-28). There was no difference in spontaneous pain behaviors between two groups. RF with VFF 0.4 and 2.0 g increased from POD3 to POD28 in both groups (p<0.05). RF with VFF 10.0 g increased from POD21 in ketamine group and from POD3 in control group (p<0.05). RF with VFF 15.0 g increased from POD21 in ketamine group and from POD5 in control group (p<0.05). Ketamine group showed lower RF than control group at POD3 and POD7 with VFF 15.0 g (p<0.05). In conclusion systemic injection of high dose ketamine for preemptive analgesia in neuropathic pain rat model delayed the onset of mechanical hyperalgesia with VFF 10.0 and 15.0 g for 3 weeks, but did not prevent the development of neuropathic pain.
3차 병원 응급실에 내원한 환자 중 1차 진료에 적합한 환자 비율에 대한 분석
이보령,황선욱,박상미,김효준 대한가정의학회 2019 Korean Journal of Family Practice Vol.9 No.6
Background: The medical service delivery system in Korea works inefficiently and patients tend to visit tertiary hospitals by means of the emergency department (ED). Overcrowding of the ED threatens the health and life of emergency patients as a result of the inability to effectively distribute emergency medical resources in the community. To solve this problem, improvement in the medical delivery system and dispersion of patients by strengthening primary care may be helpful. In order to make policy decisions for this, it is necessary to estimate the scale of patients who can be distributed to primary care. Methods: From January 1 to December 31, 2016, we analyzed the National Emergency Department Information System (NEDIS) data of patients who visited a tertiary ED to examine the proportion of patients eligible for primary medical care. The inclusion and exclusion criteria for primary care were made through the consensus of three physicians. Results: A total of 65,061 NEDIS records were analyzed. Among them, by inclusion criteria, 29,818 cases were Korean Triage and Acuity Scale level 4 and 5, and 11,791 patients visited the ED during the day. After considering the exclusion criteria, there were 6,468 cases who may be suitable for primary medical care. Conclusion: Of the patients who visited the ED of tertiary hospitals, approximately 10% of them may be suitable for primary care. There should be a discussion and social consensus to reduce overcrowding in EDs and deliver better medical services. 연구배경: 한국에서의 의료전달체계는 효율적이지 못하다. 결과적으로 환자들은 의료서비스 이용 시 대형병원을 선호하며 그 이용수단으로 응급실이 주로 사용된다. 지역 응급의료자원의 비효율적인 분배는 응급실의 과밀화를 초래하며 이는 응급환자의 생명과 안녕을 위협한다. 일차의료 활성화는 이 문제를 해결하는데 도움이 될 수 있으며 이러한 정책을 결정함에 있어서 일차의료에서 진료가가능할 것으로 생각되는 환자의 규모를 평가하는 것이 반드시 필요하다. 방법: 2016년 1월 1일부터 12월 31일까지 일개 3차 병원 응급실에 내원한 환자에 대한 National Emergency Department Information System(NEDIS) 데이터를 이용하여 일차 진료에 적합할 것으로 생각되는환자의 비율을 계산한다. 포함 및 배제에 관한 기준은 가정의학과의사 2명, 응급의학과 의사 1명의 합의로 정하였다. 결과: 총 65,061명의 NEDIS 자료를 분석하였다. 그 중 29,818명이 Korean Triage and Acuity Scale 4에서 5의 점수를 가지고 있었고 그 중 11,791명이 오전 9시부터 오후 6시사이에 응급실을 방문하였다. 본 연구의 배제 기준을 제외하고 총 6,468명의 환자가 일차 진료에 적합할 것으로 판단하였다. 결론: 3차 병원 응급실에 방문하는 환자 중 약 10% 정도가 일차 의료에 의한 진료가 가능할 것으로 판단된다. 이를 실현하기 위해서는 응급실 과밀화 해소, 더 나은 의료서비스를 위한 사회적 공감대 형성 및 합의가 필요할 것으로 생각된다.