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이동옥 ( Dong Ock Lee ),김훈 ( Hoon Kim ),채수진 ( Soo Jin Chae ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ),김정구 ( Jung Gu Kim ) 대한폐경학회 2007 대한폐경학회지 Vol.13 No.2
연구목적: 폐경 여성에서 호르몬 치료 후 전혈세포에서의 OPG, sRANKL 생산의 변화과 골밀도 변화사이의 연관성을 알아보고자 하였다. 연구재료 및 방법: 폐경여성 224명에서 LPS로 자극한 전혈세포에서 OPG, sRANKL 생산, 혈청 OST, CTX, PTH, 칼슘, 인 농도를 측정하였다. 또한 요추와 근위부 대퇴골의 골밀도를 측정하였다. 이중 주기적 에스트로겐-프로제스토젠 치료가 118명에서 시행되었다. 결과: 전혈세포에서 OPG 생산은 연령과 양성 상관관계가 있었고 저골량을 가진 여성에서 정상 여성보다 유의하게 증가하였다. 반면 sRANKL 생산과 sRANKL/OPG 비는 연령과 음성 상관 관계를 보였고 골밀도 상태에 따른 차이를 보이지 않았다. 전혈세포에서의 OPG와, sRANKL 생산 및 그 비는 혈청 OST, CTX, PTH 칼슘, 인와 상관관계가 없었다. 호르몬 치료 6개월 후 전혈세포에서의 OPG 생산은 유의하게 증가하였으나 sRANKL 생산과 sRANKL/OPG 비는 변화하지 않았다. 호르몬 치료 1년후 대퇴골경부 에서의 골밀도 변화는 호르몬 치료 전 전혈세포에서의 OPG와 sRANKL 생산과 음성 상관관계가 있었으나 sRANKL/OPG 비는 양성 상관관계를 보였다. 호르몬 치료 6개월후 전혈세포에서의 OPG와 sRANKL 생산 변화는 호르몬치료 1년후 골밀도의 변화와 상관관계가 없었다. 결론: 호르몬 치료 후 전혈세포에서의 OPG, sRANKL 생산 및 그 비의 변화는 골밀도 변화와 관련이 없으나 치료전 전혈세포에서 OPG, sRANKL 생산은 호르몬치료 1년후 대퇴골경부에서의 골밀도의 변화을 반영할 수 있다. Objectives: To investigate the relationship between changes in the production of osteoprotegerin (OPG), and soluble receptor activator for nuclear factor κB lignad (sRANKL) by whole blood cells (WBCs) and changes in bone mineral density (BMD) after hormone therapy (HT) in postmenopausal women. Methods: The production of OPG, and sRANKL by lipopolysaccharide-stimulated WBCs blood cells, serum levels of osteocalcin (OST), type I C-telopeptide breakdown products (Crosslaps; CTX), parathyroid hormone (PTH), calcium, and phosphorus were measured in 224 postmenopausal Korean women. The BMD at lumbar spine and proximal femur was also determined. One hundred and eighteen postmenopausal women took sequential estrogen-progestogen therapy. Results: The production of OPG by WBCs correlated positively with age and was significantly higher in women with low bone mass than in normal women. The production of sRANKL and sRANKL/OPG correlated negatively with age and was not different according to state of BMD. These OPG and RANKL productions did not show any relationship with serum levels of OST, CTX, PTH, calcium, and phosphorus. After 6 months of HT, the production of OPG by WBCs increased significantly, but no change in the production of sRANKL, and sRANKL/OPG ratio was noted. The 1-year change in BMD of femoral neck correlated negatively with the basal production of OPG by WBCs and positively with basal sRANKL/OPG ratio. Changes in the production of OPG and sRANKL after 6 months of HT were not associated with the 1-year change in BMD. Conclusion: After HT, changes in the production of OPG, and sRANKL by WBCs did not correlate with changes of BMD, but basal production of OPG by WBCs and sRANKL/OPG ratio correlated with changes in BMD of femoral neck after HT.
유방암 치료 후 타목시펜 사용 중 출혈이 발생한 여성에서 자궁내시경을 통한 조직검사와 큐렛을 이용한 조직검사 결과의 비교
이동옥 ( Dong Ock Lee ),주창우 ( Chang Woo Choo ),이정윤 ( Jung Yun Lee ),문경용 ( Kyoung Yong Moon ),정연경 ( Youn Kyung Chung ) 대한폐경학회 2008 대한폐경학회지 Vol.14 No.3
연구목적: 타목시펜을 사용하는 유방암 환자 중 자궁출혈을 보이는 여성에서 큐렛을 이용한 자궁내막 생검 결과와 자궁내시경을 통한 자궁내막 생검 결과를 비교하고자 하였다. 연구재료 및 방법: 총 41명의 여성이 대상이 되었으며 평균 연령은 46.7±7.2세였다. 모든 환자에서 전신 마취 후 큐렛을 이용하여 전자궁강 내 소파술을 시행하고 이어서 자궁내시경을 통한 자궁내강 평가 및 자궁내막 조직생검을 시행하여 두 검사결과를 비교하였다. 결과: 큐렛을 이용한 자궁내막 생검은 24.4%에서 진단에 부적합한 검체를 보였고 자궁내시경을 통한 조직생검은 7.3%에서 부적합 검체를 보였다. 31.7% (13/41)에서 자궁내시경을 통해 자궁내막용종이 발견되었으나 이들 환자 모두 큐렛을 이용한 조직검사에서는 정상 혹은 위축성 자궁내막을 보이거나 (11명) 부적합 검체 (2명)를 보였다. 결론: 타목시펜 사용 중 자궁출혈을 보이는 유방암 환자에서 자궁내막 병변의 정확한 평가를 위해서는 자궁내시경을 시행해야 한다. Objectives: To evaluate the accuracy of curettage compared with hysteroscopic biopsy in women on tamoxifen after the diagnosis of breast cancer. Methods: A prospective observational study conducted with forty one women with postmenopausal bleeding during tamoxifen therapy. Under anesthesia, dilatation and curettage was immediately followed by hysteroscopic biopsy and the pathologic reports were compared. Results: By curettage, 24.4% of women showed insufficient tissue for diagnosis compared with 7.3% by hysteroscopic biopsy. In thirteen women (31.7%) endometrial polyp was diagnosed by hysteroscopic biopsy, although all of them showed normal or atrophic endometirum only by curettage. Conclusion: Hysteroscopic biopsy should be used for the evaluation of endometrial pathology in women on tamoxifen after breast cancer.
로브곡선을 이용한 자동차용 신강재의 저항 점 용접성 평가 기술 개발
김태형,이동옥,이세헌,Kim, Tae-Hyung,Lee, Dong-Ock,Rhee, Se-Hun 대한용접접합학회 2005 대한용접·접합학회지 Vol.23 No.4
The resistance spot welding is one of the most commonly used welding process for joining the sheet metal in automotive manufacturing process due to higher deposition rates and higher economy achieved. Control variables in the resistance spot welding for achieving high quality are welding current, welding force and welding time. Generally at the manufacturing scene, welding current Vs welding time lobe diagram is used to estimate weldability because controlling welding force is not practical due to economical reasons. However new automotive steel plates have been developed to make lightweight automobiles and to improve resistance against rusting. Also the weldability of these steel plates are worst than the existing steel plates because of changing bare metal and surface plating effect. In consequence of above mentioned reasons, it is necessary to use welding force to present the lobe diagram. In this study, we obtained the welding force Vs welding current lobe diagram for commonly used GA steel plate and found that the second order repression model of tensile shear strength was useful in reducing the number of experiments, and the indentation, and thickness change during welding were used as a response to estimate quantitatively expulsion.
자궁경부 선암에서 고위험 인유두종바이러스 감염 양성도와 p53 단백 과발현의 관계
강석범 ( Sok Bom Kang ),이동옥 ( Dong Ock Lee ),손영수 ( Young Soo Son ),김재원 ( Jae Weon Kim ),박노현 ( Nog Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
Objective : The aim of the present study was to analyze the relation between p53 mutation and cervical adenocarcinoma without HPV infection. Methods : From 1998 to 2002, 54 patients were diagnosed with cervical adenocarcinoma and underwent radical hystere
한국 폐경여성에서 저밀도 지단백 수용체 관계 단백 5 유전자의 단일염기유전자다형성과 골량 사이의 연관성에 관한 연구
김자연 ( Ja Yeun Kim ),이동옥 ( Dong Ock Lee ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ),김정구 ( Jung Gu Kim ) 대한폐경학회 2007 대한폐경학회지 Vol.13 No.1
연구목적: 한국 폐경여성에서 저밀도 지단백 수용체 관계 단백 5 (low density lipoprotein receptor-related proteins 5; LRP5) 유전자 다형성양상과 골밀도사이에 연관성이 있는가를 알아보고자 하였다. 연구재료 및 방법: 자연폐경여성 261명에서 LRP5 유전자 내 A314G, T2268C, GInv17-30A 다형성 양상을 제한절편길이다형성 (restriction fragment length polymorphism; RFLP)으로 분석하고 혈청 CrossLaps (CTX), osteocalcin, bone alkaline phosphatase (BAP), calcitonin, 부갑상선호르몬 (parathyroid hormone; PTH), 칼슘, 인 농도를 각각 효소면역법, 면역측정법, 원자흡광법으로, 요추 및 대퇴 근위부에서의 골밀도를 이중에너지 엑스레이 흡수계측기 (DXA)로 측정하였다. 결 과: LRP 유전자 내 A314G, T2268C 다형성양상에 의한 유전자형은 AA 83.1%, AG 14.9%, GG 1.9%, CC 50.2%, CT 43.3%, TT 6.5%이었으며, GInv17-30A의 경우 GG 76.2%, GA 20.7%, AA 3.1%이었다. 이러한 다형성양상에 의한 단일 유전자형 또는 haplotype 유전자형에 따른 요추 및 근위 대퇴부에서의 골밀도에서는 차이가 없었다. 혈청 PTH 농도가 A314G 다형성의 GG 유전자형에서 AA 유전자형 또는 AG 유전자형 보다 높다는 것 이외에 다른 단일 유전자형 또는 haplotype 유전자형과 골의 생화학적 인자 농도사이에는 연관성이 없었다. 결 론: 한국 자연폐경 여성에서 LRP5 유전자 내 A314G, T2268C 및 GInv17-30A 다형성양상은 골밀도에 영향을 주지 않는다. Objectives: To investigate the relationship between low density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women. Methods: The A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene were analyzed by restriction fragment length polymorphism in 261 postmenopausal Korean women. Serum CrossLaps (CTX), bone alkaline phosphatase (BAP), osteocalcin, parathyroid hormone (PTH), calcitonin, calcium, and phosphorus levels were measured by enzyme linked immunosorbent assay, immunoassay and by atomic absorptiometry respectively. The BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. Results: The distributions of A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene were as follows; AA 83.1%, AG 14.9%, GG 1.9%, CC 50.2%, CT 43.3%, TT 6.5%, GG 76.2%, GA 20.7%, and AA 3.1%. No significant differences in adjusted BMD of lumbar spine and femoral neck were noted among single or haplotype genotypes of LRP5 gene polymorphisms. No statistical significances in associations between serum levels of bone biochemical markers except PTH and single or haplotype genotypes were observed. Serum PTH levels in women with GG genotype of A314G polymorphism was significantly higher than those in women with AA or AG genotype. Conclusion: The A314G, T2268C, and G Inv17-30 A polymorphisms in LRP5 gene do not affect BMD at the lumbar spine and proximal femur in postmenopausal Korean women.
박지윤 ( Jee Yoon Park ),박정우 ( Jeong Woo Park ),이동옥 ( Dong Ock Lee ),박찬욱 ( Chan Wook Park ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),신희철 ( Hee Chul Syn ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12
Most chemotherapeutic drugs are known to possess significant teratogenic effects. Although several agents have been proven to be safe for the fetus after organogenesis period, there is limited information on their use during pregnancy and it is very difficult to establish researches on the effect to human. We report a very unique case of unrecognized pregnancy in lung cancer patient who had been treated with variable agents of chemotherapy. A 25-year-old woman (gravida 0) who had been diagnosed as non-small cell lung cancer 6 years ago and received multiple regimens of chemotherapy presented at full term pregnancy with unknown gestational period. Without knowledge of pregnancy, she received a palliative chemotherapy with Docetaxel during first and second trimesters. Vaginal delivery with induction of labor due to postterm pregnancy was performed after evaluation of her medical condition and fetal surveillance. A 2,450 g female newborn was delivered with no evidence of congenital malformations.
복강 내 원인대를 침범한 서혜부 자궁내막증의 완전 절제
임명철 ( Myong Cheol Lim ),최지영 ( Ji Young Choi ),이동옥 ( Dong Ock Lee ),유종우 ( Jong Woo Yoo ),박상윤 ( Sang Yoon Park ),서상수 ( Sang Soo Seo ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.12
Inguinal endometriosis is a rare gynecologic disease. A 43-year-old woman had felt small nodular mass, which causing cyclic groin pain and fluctuation with menstrual cycle. CT scan revealed the extraperitoneal inguinal mass connected to the left round ligament. During the operation, infiltrative fibrotic mass around the inguinal mass could only be excised with wide groin dissection. After dissection of the abdominal muscles, the intraperitoneal mass could be pulled out and excised at the level of the intact round ligament. Histological diagnosis at the excised mass was endometriosis. After the surgery, the pain disappeared completely. We have reviewed published articles concerning inguinal endometriosis. The mechanism of development of inguinal endometriosis seems to be to that of indirect hernia with a difference of disappearing hernia sac resulting from inflammation of endometriosis. About half of the patients revealed periodicity such as cyclic pain or fluctuation of pain with menstral cycle. We describe the complete surgical excision of extraperitoneal inguinal endometriosis connected to round ligament endometriosis. Successful treatment can be achieved with understanding of the pathophysiology and anatomy related to the inguinal endometriosis.