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2P-359 Improved Pterostilbene Production by Co-culture of E.coli and Streptomyces venezuelae
이나령,( Cui Heqing ),송명종,신혜령,이지영,조진철,윤여준 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Pterostilbene is an effective anti-tumor and antioxidant agent as a resveratrol derivative with two additional methyl branch, thus has significant advantages over resveratrol. The biosynthesis of pterostilbene is derived from phenylpropanoid pathway. The p-coumaric acid is converted to p-coumaric CoA by p-coumarate CoA ligase (4CL) and it combines with three malonyl-CoA to produce resveratrol by stilbene synthase (STS). Next, by series action of 3,5-O-methyltransferase (ROMT), pterostilbene is produced. In this study, 4CL and STS coding genes were transformed into E.coli BL21 (DE3) and ROMT coding gene into Streptomyces venezuelae DHS2001, respectively. Finally, the pterostilbene production was enhanced when the recombinants were incubated in the co-culture system. This result provides the potential utility of the co-culture system for efficient pterostilbene manufacturing.
대학생의 성인애착이 대인관계문제에 미치는 영향 -공적 자의식, 우울취약성, 정서적 단절의 매개효과-
이은진 ( Eun Jin Lee ),이나령 ( Na Ryung Lee ),이지연 전북대학교 사회과학연구소 2015 지역과 세계 Vol.39 No.2
The present study aimed to confirm the mediational effects of public self-consciousness, vulnerability to depression, and emotional cutoff in the relationship between adult attachment (attachment anxiety and attachment avoidance) and interpersonal problems. To this end, the adult attachment, interpersonal problems, public self-consciousness, vulnerability to depression, and emotional cutoff of 264 university students attending universities in Seoul and surrounding areas were measured. The data were analyzed using structural equation modeling. The results showed that in the relationship between attachment anxiety and interpersonal problems, the mediational paths from attachment anxiety to interpersonal problems via vulnerability to depression, via vulnerability to depression and then to emotional cutoff, via public self-consciousness and then to vulnerability to depression, and via public self-consciousness, vulnerability to depression, and then to emotional cutoff, were all significant. In addition, attachment avoidance showed both significant direct and indirect effects on interpersonal problems, suggesting that emotional cutoff partially mediated the relationship between these two constructs.
Generation of glycosylated macrolactam analogues through chemoenzymatic synthesis
김면수,김은지,황재연,( Cui Hequing ),( Jin Shi Ying ),정진아,이나령,윤여준 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
Macrocyclic poliketides have been identified as rich sources of novel metabolites with promising therapeutic potentials. While the macrolactone plays a pivotal role in pharmacological acivity of the compounds, the susceptibility of this ring system to degradation by acidic PH, esterases, and various enzymes has increased our interest for analogue generation through structural modification. YC-17 is a macrolactone antibiotic produced from S. venezuelae and is composed of the polyketide macrolactone appended with a sugar moiety. Through a combined approach involving chemical synthesis and biotransformation, eight new analogues of YC-17 were generated. Some YC-17 analogues displayed enhanced activity against erythromycin resistant bacterial pathogens and improved metabolic stability in vitro. These results demonstrate the successful application of chemoenzymatic synthesis in therapeutic agents discovery and development.