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- 저자 : 이광훈 ( Heun Jung Cho (검색결과 5 건)
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아토피 피부염 환자에서 Dermatophagoides Farinae 항원에 대한 특이 IgE 및 IgG4항체
조흔정 ( Heun Jung Cho ),최현주 ( Hyun Joo Choi ),김동건 ( Dong Kun Kim ),이광훈 ( Kwang Hoon Lee ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.1
Background: The pathogenesis of atopic dermatitis is still unknown. Many reports have suggested that the house dust mite antigen may play a role in the pathogenesis of atopic dermatitis. The IgG4 allergen-specific subclass has been considered to be involved both in allergic reactions and associated with the appropriate response to allergen-specific immunotherapy. Object : The purpose of this study was to evaluate the positive rate of the allergic prick test to D. farinae and the levels of D. farinae-specific IgE and Ig64. Methods : We performed the allergy prick test, RAST for D. farinae-specific IgE and ELISA for D. farinae-specific IgG subclasses and compared the values between atopic dermatitis patients and normal controls. Results 1. D. farinae was the most common allergen in patients with atopic dermatitis and the positive rate of the allergic prick test was 61.0%. The positive rate of the allergic prick test and the positive rate to D. farinae increased as c]inical grading increased. 2. The Positive reaction rate of D. farinae-specific IgE(RAST) in those with atopic dermatitis was 68.8% and increased as the positive reactions of the allergic prick test to D. farinae and chnical grading increased. 3. Among the IgG subclasses, only the level of D. farinae-specific IgG4 was significantly higher in atopic dermatitis than normal controls. 4. The level of D. farinae-specific IgG4 showed a tendency to decrease in accordance with the clinical severity grades. Conclusion : These results suggested that D. farinae might play an important role in the development of atopic dermatitis and well-designed studies should continue to be performed in order to delineate the biological significance of IgG4. (Korean J Dermatol 1998;36(1): 16-22)
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만성 광선 피부염에서 Cyclosporine 치료의 효과 및 의의
조흔정,한승경,신항계,박윤기,이광훈 ( Heun Jung Cho,Seung Kyung Hann,Hang Kye Shin,Yoon Kee Park,Kwang Hoon Lee ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3
Background: Chronic actinic dermatitis comprises a spectrum of chronic photosensitivity disorders. Treatment includes avoidance of UV light, application of broad-spectrum topical sunscreens, PUVA therapy, corticosteroid, azathioprine and cyclosporine. Objective : Our purpose was to determine the efficacy of cyclosporine in the treatment of chronic actinic dermatitis. Methods : Six patients with chronic actinic dermatitis refractory to conventional treatment were treated with cyclosporine 100-200mg a day for four to eighteen weeks. Results . In all six patients improvement of the skin lesions and itching were dramatic, but in three of them hyperterision developed during the cyclosporine treatment. After stopping the cyclosporine therapy, their blood pressures normalized within two to five weeks. Other side effects of cyclosporine were not found. Although the skin lesions of all of the six patients were aggravated more or less after stopping the cyclosporine therapy, we could maintain their improved states with topical corticosteroids and oral antihistamines. Conclusion 1. Cyclosporine is a good alternative in treating chronic actinic dermatitis patients who are suffering from severe symptoms refractory to conventional therapy. 2. Hypertension is the frequent side effect of cyclosporine. (Kor J Dermatol 1997;36(3): 458-464)
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증례 / Meperidine에 의해 유발된 피부의 국소 과민방응 2례
김홍석(Hong Suk Kim),조흔정(Cho Heun Jung),이광훈(Kwang Hoon Lee) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1
Meperidine, as well as other drugs and colloid solutions commonly used during the perianesthetic period, are capable of releasing histamine from mast cells both in vitro and in vivo in animals and human. This histamine release from mast cells is thought not to represent a true allergic response, but rather the basic ability of these drugs to act directly in some unknown manner, the so-called pseudo-allergic or anaphylactoid reaction. Such reactions have been estimated to occur as frequently as one in every 400-1000 anesthetics. We present two patients, aged 58 and 47 with internal malignancy admitted to our hospital whose chief complaints were erythematous plaques in the buttock. They were treated for pain by intramuscular injection of meperidine in the buttock and were skin-tested intradermally with meperidine hydrochloride. Skin tests elicited a positive immediate skin test reaction in both patients.
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자연 치유된 원발성 피부 Alternariosis 2예
정예리,장성남,한승경,조흔정,서순봉,이광훈 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2
The treatment of cutaneous altemariosis consists of surgical excision and systemic antifungal agent. However, only reduction or cessation of corticosteroids and immunosuppressive therapy, if it is possible, can be sufficient to treat the lesion in some cases. We present two cases of spontaneously healed primary cutaneous altemariosis. Case 1 was a 73-year-old female patient with diabetes mellitus, heart failure, chronic renal failure and chronic hepatitis. Case 2 was a 64-year-old male patient with iatrogenic Cushing's syndrome and diabetes mellitus. The correction of the underlying diseases resulted in improvement of the primary cutaneous altemariosis. [Kor J Med Mycol 4(2): 137-142]
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