기업탐방 - FAG베어링코리아 창원공장

이계화,Lee, Gye-Hwa 대한산업보건협회 2005 산업보건 Vol.210 No.-

Extracting Structured Genotype Information from Free-Text HLA Reports Using a Rule-Based Approach

이계화,김효정,김이준,김주한,송은영 대한의학회 2020 Journal of Korean medical science Vol.35 No.12

Background: Human leukocyte antigen (HLA) typing is important for transplant patients to prevent a severe mismatch reaction, and the result can also support the diagnosis of various disease or prediction of drug side effects. However, such secondary applications of HLA typing results are limited because they are typically provided in free-text format or PDFs on electronic medical records. We here propose a method to convert HLA genotype information stored in an unstructured format into a reusable structured format by extracting serotype/ allele information. Methods: We queried HLA typing reports from the clinical data warehouse of Seoul National University Hospital (SUPPREME) from 2000 to 2018 as a rule-development data set (64,024 reports) and from the most recent year (6,181 reports) as a test set. We used a rule-based natural language approach using a Python regex function to extract the 1) number of patients in the report, 2) clinical characteristics such as indication of the HLA testing, and 3) precise HLA genotypes. The performance of the rules and codes was evaluated by comparison between the extracted results from the test set and a validation set generated by manual curation. Results: Among 11,287 reports for development set and 1,107 for the test set describing HLA typing for a single patient, iterative rule generation developed 124 extracting rules and 8 cleaning rules for HLA genotypes. Application of these rules extracted HLA genotypes with 0.892–0.999 precision and 0.795–0.998 recall for the five HLA genes. The precision and recall of the extracting rules for the number of patients in a report were 0.997 and 0.994 and those for the clinical variable extraction were 0.997 and 0.992, respectively. All extracted HLA alleles and serotypes were transformed according to formal HLA nomenclature by the cleaning rules. Conclusion: The rule-based HLA genotype extraction method shows reliable accuracy. We believe that there are significant number of patients who takes profit when this under-used genetic information will be return to them.

위축된 유아와 일반유아의 모래놀이와 K-HTP 표현 비교 연구

이계화,이정숙 한국아동심리재활학회 2006 놀이치료연구 Vol.10 No.1

The purpose of this study is to prove the sand tray play can be useful tool to discriminate withdrawn children from ordinary children by analyzing the characteristics of sand tray expression. For this study, thirty withdrawn and another thirty ordinary children were tested in terms of making time, number of toys, number of toys by categories and number of categories, first selected toy and preference, pattern of space use, characteristics of expression of sand tray and K-HTP of withdrawn and ordinary children. And the results were as follows: the starting time was different between withdrawn and ordinary children, but, there was not any considerable difference total duration. there were considerable differences in the total number of toys, number of toys by categories, number of categories. There was considerable differences in the pattern of the space uses in the characteristics of the sand tray expressions. the K-HTP was analyzed of that there were differences in erasing, weak pencil grasping, expressing shadows, expressing other people, sticking, detailing expression, edges, symbol 4, sizing of picture. the relation of the K-HTP and the sand tray, we can realize that the withdrawn children draw small size picture, use edge of paper, have more erasing and shadows, and these characteristics have some relation with the under-half space use, the using out of the sand tray, and the long starting time. 본 연구는 위축유아와 일반유아의 모래상자 표현특성을 비교하고 모래상자놀이와 동적 집-나무-사람(K-HTP)이 위축유아를 변별해 주는 유용한 도구인지 입증해 보고자 위축유아(30명)와 일반유아(30명)의 모래상자 제작시간, 사용한 놀잇감의 전체 수, 범주별 사용한 놀잇감의 수와 범주 수, 최초 놀잇감과 선호도, 공간 활용 형태, 모래상자의 표현특성과 위축유아와 일반유아의 K-HTP를 비교하였으며, K-HTP와 모래상자와의 관계를 살펴보았다. 그 결과는 다음과 같다. 위축유아와 일반유아간의 제작시간 차이에서, 초발시간에서는 유의미한 차이가 있었으나 제작시간 및 총 시간에서는 유의미한 차이가 없었다. 놀잇감 차이에서는 사용한 장난감의 전체수, 범주별 장난감의 수와 범주 수에서 유의미한 차이가 있었다. 또한, 위축유아와 일반유아에 따라 모래상자 공간 활용 형태와 표현특성에서 유의미한 차이가 있었으며, K-HTP를 분석한 결과에서는 지움, 약한 필압, 음영, 타인묘사, 부착, 세부묘사, 가장자리, 상징 4, 그림의 크기에서 유의미한 차이가 나타났다. 동적 집-나무-사람(K-HTP)과 모래상자의 관계를 살펴보면, 긴장되고 불안하며 위축된 유아는 그림의 크기가 작고, 가장자리에 그림을 그리거나, 지우기나 음영이 많은데, 이는 모래상자의 공간배치가 반 이하이고, 모래상자 밖을 활용하거나, 모래상자놀이를 시작하기까지의 초발시간이 긴 경우들과 연관되어 있음을 알 수 있다.

한자 습득이 중국어 읽기 학습 성취도에 미치는 효과 -대학교 1학년 중국어 독해 초급과정을 중심으로-

이계화,김세리 한국중국언어문화연구회 2008 한중언어문화연구 Vol.- No.17

In studying the Chinese language, it is more important than anything else to learn accurately Chinese characters that symbolize the Chinese language. If the major concern of the Chinese language education is to maximize the Chinese language capability of learners within the shortest period, the education of Chinese characters is a basic and difficult point of the Chinese language education. Reading is a linguistic function which can be approached most efficiently. This is because the learners are already seeing and reading the characters on opening books. Therefore, reading is an important linguistic function to be trained from the beginning stage of the Chinese language study. In this paper, through a survey of questionnaire, we propose that securing the ability of reading the Chinese language and the proficiency in that language is significantly dependent on the acquisition of Chinese characters. In addition, the result indicates that adopting the education of Chinese characters into the traditional reading class has a positive effect on the achievement level of learner’s performance in reading. Finally, admitting the limit of this study, more scrutinized analyses of the effects of acquisition of the Chinese characters on the vocabulary, grammatical structures, sentence comprehension, reading speed, etc. are suggested, as well as a study on how the acquisition of the Chinese characters may influence other linguistic functions when the teaching of Chinese characters is applied to the classes for listening, speaking and writing of the Chinese language.

ANNO: A General Annotation Tool for Bilingual Clinical Note Information Extraction

이계화,Hyunsung Lee,박진혁,이영호 대한의료정보학회 2022 Healthcare Informatics Research Vol.28 No.1

Objectives: This study was conducted to develop a generalizable annotation tool for bilingual complex clinical text annotation,which led to the design and development of a clinical text annotation tool, ANNO. Methods: We designed ANNO toenable human annotators to support the annotation of information in clinical documents efficiently and accurately. First,annotations for different classes (word or phrase types) can be tagged according to the type of word using the dictionaryfunction. In addition, it is possible to evaluate and reconcile differences by comparing annotation results between humanannotators. Moreover, if the regular expression set for each class is updated during annotation, it is automatically reflectedin the new document. The regular expression set created by human annotators is designed such that a word tagged once isautomatically labeled in new documents. Results: Because ANNO is a Docker-based web application, users can use it freelywithout being subjected to dependency issues. Human annotators can share their annotation markups as regular expressionsets with a dictionary structure, and they can cross-check their annotated corpora with each other. The dictionary-basedregular expression sharing function, cross-check function for each annotator, and standardized input (Microsoft Excel) andoutput (extensible markup language [XML]) formats are the main features of ANNO. Conclusions: With the growing needfor massively annotated clinical data to support the development of machine learning models, we expect ANNO to be helpfulto many researchers.

신체활동도와 건강관련 삶의 질과의 연관성 - 일개 건강검진 수검자들을 대상으로

이계화,김철환,신호철,박용우,성은주 대한가정의학회 2007 Korean Journal of Family Medicine Vol.28 No.6

The Relation of Physical Activity to Helath Related Quality of Life Gye Hwa Lee M.D., Cheol Hwan Kim M.D.†, Ho Cheol Shin M.D., Yong Woo Park M.D., Eun Ju Sung M.D. 연구배경: 신체활동 증진이 사망률 및 이환율의 감소와 연관이 있다는 많은 연구들이 있어 왔으며 신체활동이 개인의 삶에 미치는 긍정적인 영향을 줄 수 있다는 것도 외국의 여러 연구에서 보고되었다. 본 연구는 신체활동이 건강한 한국의 성인에서 건강관련 삶의 질과 관련이 있는지를 조사하기 위하여 시행되었다. 방법: 연구대상은 2006년 4월 1일부터 2006년 5월 30일까지 강북삼성병원 건강검진센터에 예약된 수검자를 대상으로 하였으며 총 1,000명에게 우편으로 설문지를 발송하였다. 이중 남자 214명, 여자 195명이 최종 연구대상이었다. 신체활동도는 국제신체활동도 단축형 자가기입식 설문지(IPAQ-short fom)의 한국어 번역판을 이용하였고 건강관련 삶의 질은 CMCHS ver 1.0을 이용하였다. 연구대상자는 남성과 여성으로 구분하고 신체활동도 점수에 따라 권장량 이상의 신체활동을 하는 군과 그렇지 않은 군으로 분류하였다. 결과: 권장량 이상의 신체활동을 시행하는 군에서 그렇지 못한 군보다 모든 삶의 질 척도가 높다는 관련성을 보였다. 건강관련 삶의 질과 관련된 여러 요인들을 보정한 후 여성에서는 권장량 이상의 신체활동을 하는 군이 그렇지 않은 군에 비해 현재 건강상태에 대한 인식, 건강 상태에 대한 만족도, 신체 통증, 신체적 기능, 정서적 기능, 사회적 기능 및 전반적 건강 척도 점수가 통계적으로 유의하게 높았다. 하지만 남성에서는 유의한 차이가 없는 것으로 나타났다. 결론: 본 연구 결과 건강한 성인 여성에서 신체활동 정도와 건강관련 삶의 질은 유의한 관련성이 있는 것으로 보였다.

Evaluating the Landscape of Personal Health Records in Korea: Results of the National Health Informatization Survey

이계화,이유라,이재호 대한의료정보학회 2023 Healthcare Informatics Research Vol.29 No.4

Objectives: This study examined the adoption and utilization of personal health records (PHR) across Korean medical institutionsusing data from the 2020 National Health and Medical Informatization Survey. Methods: Spearheaded by the Ministryof Health and Welfare and prominent academic societies, this study surveyed PHR utilization in 574 medical institutions. Results: Among these institutions, 84.9% (487 hospitals) maintained medical portals. However, just 14.1% (81 hospitals)had web-based or mobile PHRs, with 66.7% (28 of 42) of tertiary care hospitals adopting them. Tertiary hospitals led in PHRservices: 87.8% offered certification issuance, 51.2% provided educational information, 63.4% supported online payment,and 95.1% managed appointment reservations. In contrast, general and smaller hospitals had lower rates. Online medicalinformation viewing was prominent in tertiary hospitals (64.3%). Most patients accessed test results via PHRs, but other datatypes were less frequent, and only a few allowed downloads. Despite the widespread access to medical data through PHRs,integration with wearables and biometric data transfers to electronic medical records remained low, with limited plans forexpansion in the coming three years. Conclusions: Approximately two-thirds of the surveyed medical institutions providedPHRs, but hospitals and clinics in charge of community care had very limited PHR implementation. Government-led leadershipis required to invigorate the use of PHRs in medical institutions.

조지아 Adjara Bypass Road Development Project의 터널설계

이계화,소충섭,한석희,이완재,문철화,이창원,김근수,모상칠,Lee, Gye-Hwa,So, Chung-Seop,Han, Seok-Hui,Lee, Wan-Jae,Mun, Cheol-Hwa,Lee, Chang-Won,Kim, Geun-Su,Mo, Sang-Chil 한국터널지하공간학회 2012 자연, 터널 그리고 지하공간 Vol.14 No.2

예비사회복지사의 인권태도, 다문화역량, 다문화수용성 간의 관계

이계화,김정미 한국국제문화교류학회 2023 문화교류와 다문화교육 Vol.12 No.3

This study examines the effects of human rights attitudes and multicultural competencies of prospective social workers on multicultural acceptance. To this end, the response data of 280 prospective social workers who completed social welfare practice among university students in Seoul, Gyeonggi, and Daegu/Gyeongbuk region were analyzed. The result is: First, it was confirmed that the average score of human rights attitude, multicultural competency, and multicultural acceptance was higher than the middle. Second, the relationship between human rights attitude, multicultural competency, and multicultural acceptability showed a positive correlation. Third, as a result of verifying the effect of human rights attitude and multicultural competence on multicultural acceptance, both variables were found to have an effect on multicultural acceptance. Through these results, as a way to improve the multicultural acceptance of prospective social workers, the necessity of human rights education and the development and implementation of a program to promote multicultural competence was suggested 본 연구는 예비사회복지사의 인권태도와 다문화역량이 다문화수용성에 미치는 영향을 검증하는 것이다. 이를 위해 서울, 경기, 대구‧경북지역 소재 대학생 중 사회복지실습을 마친 예비사회복지사 280명의 응답 자료를 분석하였다. 결과는 다음과 같다. 첫째, 인권태도, 다문화역량, 다문화수용성의 평균점수는 각각3.64, 3.64, 4.04로 높게 나타났다. 둘째, 인권태도, 다문화역량, 다문화수용성 간의 관계는 긍정적인 상관관계를 보였다. 셋째, 인권태도와 다문화역량이 다문화수용성에 미치는 영향을 검증한 결과 두 변수 모두 다문화수용성에 영향을 미치는 것으로 조사되었다. 이러한 결과를 통해 예비사회복지사의 다문화수용성을 향상시키는 방안으로 인권교육과 다문화역량을 고취시키는 프로그램의 개발 및 실행의 필요성을 제시하였다.

Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis

이계화,임재현,김주한 한국유전체학회 2013 Genomics & informatics Vol.11 No.1

In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.