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12주간 태음조위탕 투여가 흰쥐의 간기능 효소와 간내 지방축적에 미치는 영향
윤진환,류성환,정경훈,최덕구,정일규,이희혁,김종오,임은미 한국운동과학회 2002 운동과학 Vol.11 No.1
윤진환, 류성관, 정경훈, 최덕구, 정일규, 이희혁, 김종오, 임은미. 12주간 태음조위탕 투여가 흰쥐의 간기능 효소와 간내 지방축적에 미치는 영향. 운동과학, 제11권 제1호, 53-65, 2002.본 연구는 태음조위탕의 비만 치료 효과에 대한 생리적인 결과뿐만 아니라 간 조직의 형태 변화에 중점을 두고 흰쥐 체중, 효소활성도틀 비롯해 인체내 대사가 가장 활발한 기관인 간의 조직을 살펴봄으로써 태음조위탕이 비만치료에 미치는 효과를 알아보기 위하여 시행되어졌다. 12주간 태음조위탕를 투여한 결과 다음과 같은 결론을 얻었다. 1) 태음조위탕을 복용한 군이 대조군에 비해 체중의 증가가 현저하게 낮았으며[F_(3,16)=l1324.047 P=.000], 간 무게에 있어서도 태음조위탕을 복용한 군이 대조군에 비해 약간 낮은 것으로 나타났다. 2) 총 콜레스테롤, LDL-Cholesterol, 중성지방, Al의 수준과 동맥경화지수는 대조군에 비해 태음조위탕을 복용한 군이 더 낮게 나타났으며{각각 [F_(3,16)=18.003 P=.001], [F_(3,16)=2456.437 P=.000], [F_(3,16)=413.735 P=.000], [F_(3,16)=465.003 P=.000]}, HDL-Cholesterol은 대조군에 비해 태음조위탕 복용군이 더 높게 나타났다[F_(3,16)=2195.873 P=.000]. 3) 혈중 GOT와 GPT수준은 대조군과 태음조위탕을 복용한 군간에는 유의한 차이는 보이지 않았으나 태음조위탕을 복용한 군에서 약간 낮게 나타났다. 4) Hematoxylin-eosin으로 염색한 결과 실험군의 간소엽에서 세포내 대사율 저하를 암시하는 물질들의 변형과 핵 손실이 나타났으며 수컷보다는 암컷 흰쥐의 간세포 변화가 급격하였다. 5) Sudan Black B로 지질과 지방세포를 염색한 결과 실험군이 대조군에 비해 지방침착정도가 낮았고 암컷 흰쥐가 수컷보다 지방성분이 감소하였다. 따라서 비만치료제로 쓰이는 태음조위탕은 간기능에 부정적 영향을 주지않으며 간내 지방축적을 감소시키고 암컷 흰쥐에서 효과가 더 있는 것으로 나타났다. Yoon, J.H., Ryu, S.H., Jeong, K.H., Choi, D.G, Jeong, I.K., Lee, H.H, Kim, J.O., Lim, EM. Effects of 12 Weeks Taeyeumjoweetang Administration on Enzymes and Fat Accumulation in Rat Liver Cells. Exercise Science, 11(1): 53-65, 2002. Taeyeumjoweetang is associated with improving liver function as well as lowing increased levels of lipid profiles. These factors are known to reduce body fat mass in 'the Taeyeum person'. The purpose of this study was to investigate the effects of acute Taeyeumjoweetang administration on enzymes and fat accumulation in rat liver cells. Sixteen Sprague-Dawley rats(16weeks old) were randomly assigned into two groups; the control group(n=8) and the experimental group(n=8). The experimental rats were given the consumption of 50㎖ of the herb tea a day for 12 weeks. The data for TC, LDL, HDL and AI were measured in plasma blood, and GOT and GPT were measured in liver. An alpha level of .05 was used as the criteria for significance. The obtained results are as follows: 1. There were significant differences in body weight between the two groups. The herb-intake rats were lower than Placebo rats in body weight, but no significant differences in liver weight. 2. There were significant differences in TC, LDL and AI between the two groups. The herb-intake rats were lower than placebo rats in body weight. .But HDL levels in the herb-intake rats were highly than placebo rats. 3. There were no significant differences in GOT, GPT between two groups. But the levels in the herb-intake rats were highly than placebo rats. 4. It was implied that female rats may have more changes in liver cells and nucleus lose than male rats in the herb-intake group. 5. As results of lipid and adipose cell stain, the herb-intake rats were lower than placebo rats in fat accumulation, and female rats had lower fat than male rats in the herb-intake group. Therefore, the data suggest that Taeyeumjoweetang administration has an effect to reduce fat accumulation without the side effects especially in female rats.
빅데이터 기반의 ETL 모델을 활용한 기업 내부정보 유출 방지 방안
윤진환,신용태 한국IT정책경영학회 2018 한국IT정책경영학회 논문지 Vol.10 No.1
Recently, it is increasingly necessary to analyze regular/unstructured data logs/events occurring between various security systems at a high speed. In order to apply the traditional security system constructed in relational DB to Bigdata environment, we need an improved ETL model for big data processing. In this paper, we propose a method to utilize the existing Extract/Transform/Load(ETL) model for log/event collection and analysis in big data security log/event collection and analysis processing. The Big Data-based ETL model proposed in this paper focuses on preventing leakage of internal information, but ultimately it can predict risks by visualizing security threats.
지구성 훈련이 흰쥐의 혈청 및 간의 지질수준에 미치는 영향
윤진환,이세호 고려대학교 스포츠과학연구소 1994 스포츠科學論叢 Vol.5 No.1
The purpose of this study was to investigate the changes of serum lipids and liver lipids concentrations by the effects of Endurance Training in rats. The subjects of this study were 12 month old male rats of sprague-Dawley family. The selected rats were randomly divided into training(n=10) and control group(n=10). The training group was trained 6-weeks on a rat treadmill. The running time and the speed of treadmill were increased(pattengale & Holloszy, 1967. applied methods). Student's t-test was performed to analyze the difference between the training group and the control group. The follwing results were observed. There was a statistically significant(p$lt;0.001) the senim lipids and liver lipids of rat between the Training group after 6-weeks endurance training. physical exercise has profound effects upon serum lipids as well as on the activity of the enzyme lipoprotein lipase(LPL). The cholesterol distribution among serum lipoproteins was dramatically modified: HDL-C increased significantly. However, Total lipids and triglycerides concentrations of serum liver were lower training Group than control Group. All those changes are consistent with an incredsed activity of the LPL.